登録情報 | データベース: PDB / ID: 8bx2 |
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タイトル | Oct4/Sox2 protein:DNA complex |
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要素 | - POU domain, class 5, transcription factor 1
- Transcription factor SOX-2
- UTF1_f
- UTF1_r
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キーワード | TRANSCRIPTION / Oct4 / Sox2 / UTF1 |
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機能・相同性 | 機能・相同性情報
diencephalon morphogenesis / olfactory placode formation / lens induction in camera-type eye / ectodermal cell fate commitment / response to benzoic acid / retina morphogenesis in camera-type eye / regulation of myofibroblast cell apoptotic process / mesodermal cell fate commitment / HMG box domain binding / detection of mechanical stimulus involved in equilibrioception ...diencephalon morphogenesis / olfactory placode formation / lens induction in camera-type eye / ectodermal cell fate commitment / response to benzoic acid / retina morphogenesis in camera-type eye / regulation of myofibroblast cell apoptotic process / mesodermal cell fate commitment / HMG box domain binding / detection of mechanical stimulus involved in equilibrioception / pigment biosynthetic process / trophectodermal cell fate commitment / forebrain neuron differentiation / blastocyst growth / anatomical structure formation involved in morphogenesis / positive regulation of epithelial cell differentiation / regulation of asymmetric cell division / response to oxygen-glucose deprivation / endodermal cell fate specification / adenohypophysis development / Deactivation of the beta-catenin transactivating complex / tongue development / endodermal cell fate commitment / germ-line stem cell population maintenance / positive regulation of cell-cell adhesion / POU domain binding / detection of mechanical stimulus involved in sensory perception of sound / neuron fate commitment / negative regulation of calcium ion-dependent exocytosis / trophectodermal cell differentiation / neuronal stem cell population maintenance / male genitalia development / female germ cell nucleus / cell fate specification / germ cell nucleus / inner ear morphogenesis / epithelial tube branching involved in lung morphogenesis / RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding / stem cell population maintenance / negative regulation of osteoblast differentiation / cell fate commitment / positive regulation of neuroblast proliferation / lung alveolus development / positive regulation of Notch signaling pathway / negative regulation of Wnt signaling pathway / cytokine binding / somatic stem cell population maintenance / inner ear development / : / negative regulation of cell differentiation / blastocyst development / regulation of neurogenesis / negative regulation of neuron differentiation / cellular response to cadmium ion / neuroblast proliferation / positive regulation of transcription initiation by RNA polymerase II / cis-regulatory region sequence-specific DNA binding / embryonic organ development / male germ cell nucleus / response to retinoic acid / forebrain development / Notch signaling pathway / lysine-acetylated histone binding / transcription repressor complex / positive regulation of neuron differentiation / cellular response to leukemia inhibitory factor / stem cell differentiation / positive regulation of cell differentiation / sensory perception of sound / negative regulation of canonical Wnt signaling pathway / brain development / neuron differentiation / chromatin DNA binding / Wnt signaling pathway / cerebral cortex development / osteoblast differentiation / gene expression / DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor binding / transcription regulator complex / sequence-specific DNA binding / RNA polymerase II-specific DNA-binding transcription factor binding / transcription cis-regulatory region binding / transcription by RNA polymerase II / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of gene expression / negative regulation of DNA-templated transcription / chromatin binding / ubiquitin protein ligase binding / regulation of transcription by RNA polymerase II / positive regulation of gene expression / positive regulation of DNA-templated transcription / chromatin / regulation of DNA-templated transcription / nucleolus / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding類似検索 - 分子機能 Transcription factor SOX / SOX transcription factor / : / : / POU-specific domain / POU domain / Pou domain - N-terminal to homeobox domain / POU-specific (POUs) domain signature 1. / POU-specific (POUs) domain signature 2. / POU-specific (POUs) domain profile. ...Transcription factor SOX / SOX transcription factor / : / : / POU-specific domain / POU domain / Pou domain - N-terminal to homeobox domain / POU-specific (POUs) domain signature 1. / POU-specific (POUs) domain signature 2. / POU-specific (POUs) domain profile. / Found in Pit-Oct-Unc transcription factors / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / 'Homeobox' domain profile. / Homeodomain / Homeobox domain / HMG (high mobility group) box / HMG boxes A and B DNA-binding domains profile. / high mobility group / High mobility group box domain / High mobility group box domain superfamily / Lambda repressor-like, DNA-binding domain superfamily / Homeobox-like domain superfamily類似検索 - ドメイン・相同性 DNA / DNA (> 10) / POU domain, class 5, transcription factor 1 / Transcription factor SOX-2類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.14 Å |
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データ登録者 | Chojnowski, G. / Wilmanns, M. / Round, E. |
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資金援助 | 1件 |
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引用 | ジャーナル: To Be Published タイトル: Crystal structure of Oct4-Soc2-UTF1 complex 著者: Chojnowski, G. / Wilmanns, M. / Round, E. |
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履歴 | 登録 | 2022年12月7日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2023年12月20日 | Provider: repository / タイプ: Initial release |
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