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基本情報
登録情報 | データベース: PDB / ID: 8bu4 | ||||||||||||||||||||||||
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タイトル | Structure of DDB1 bound to DS22-engaged CDK12-cyclin K | ||||||||||||||||||||||||
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![]() | LIGASE / kinase / cyclin / ubiquitin / degrader | ||||||||||||||||||||||||
機能・相同性 | ![]() cyclin K-CDK12 complex / cyclin K-CDK13 complex / nuclear cyclin-dependent protein kinase holoenzyme complex / regulation of MAP kinase activity / cyclin/CDK positive transcription elongation factor complex / negative regulation by host of viral genome replication / positive regulation by virus of viral protein levels in host cell / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / negative regulation of stem cell differentiation ...cyclin K-CDK12 complex / cyclin K-CDK13 complex / nuclear cyclin-dependent protein kinase holoenzyme complex / regulation of MAP kinase activity / cyclin/CDK positive transcription elongation factor complex / negative regulation by host of viral genome replication / positive regulation by virus of viral protein levels in host cell / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / negative regulation of stem cell differentiation / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair / cyclin-dependent protein serine/threonine kinase activator activity / cyclin-dependent kinase / positive regulation of DNA-templated transcription, elongation / cyclin-dependent protein serine/threonine kinase activity / [RNA-polymerase]-subunit kinase / biological process involved in interaction with symbiont / regulation of mitotic cell cycle phase transition / Cul4A-RING E3 ubiquitin ligase complex / WD40-repeat domain binding / ubiquitin ligase complex scaffold activity / Cul4B-RING E3 ubiquitin ligase complex / regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of reproductive process / negative regulation of developmental process / RNA polymerase II CTD heptapeptide repeat kinase activity / cullin family protein binding / HIV elongation arrest and recovery / Pausing and recovery of HIV elongation / RNA polymerase II transcribes snRNA genes / cyclin binding / viral release from host cell / regulation of signal transduction / ectopic germ cell programmed cell death / proteasomal protein catabolic process / Formation of HIV elongation complex in the absence of HIV Tat / positive regulation of viral genome replication / positive regulation of transcription elongation by RNA polymerase II / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / positive regulation of gluconeogenesis / RNA Polymerase II Pre-transcription Events / RNA splicing / regulation of circadian rhythm / nucleotide-excision repair / TP53 Regulates Transcription of DNA Repair Genes / Recognition of DNA damage by PCNA-containing replication complex / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / DNA Damage Recognition in GG-NER / Transcription-Coupled Nucleotide Excision Repair (TC-NER) / Formation of TC-NER Pre-Incision Complex / Dual Incision in GG-NER / Wnt signaling pathway / Formation of Incision Complex in GG-NER / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / mRNA processing / positive regulation of protein catabolic process / rhythmic process / cellular response to UV / Neddylation / protein-macromolecule adaptor activity / site of double-strand break / chromosome, telomeric region / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / protein autophosphorylation / transcription by RNA polymerase II / damaged DNA binding / protein kinase activity / protein ubiquitination / nuclear speck / cell division / DNA repair / protein serine kinase activity / DNA damage response / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / protein-containing complex binding / nucleolus / protein kinase binding / apoptotic process / positive regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / extracellular space / extracellular exosome / nucleoplasm / ATP binding / nucleus / cytoplasm 類似検索 - 分子機能 | ||||||||||||||||||||||||
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手法 | ![]() ![]() ![]() | ||||||||||||||||||||||||
![]() | Kozicka, Z. / Kempf, G. / Focht, V. / Thoma, N.H. | ||||||||||||||||||||||||
資金援助 | European Union, ![]()
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![]() | ![]() タイトル: Design principles for cyclin K molecular glue degraders. 著者: Kozicka, Z. / Suchyta, D.J. / Focht, V. / Kempf, G. / Petzold, G. / Jentzsch, M. / Zou, C. / Di Genua, C. / Donovan, K.A. / Coomar, S. / Cigler, M. / Mayor-Ruiz, C. / Schmid-Burgk, J.L. / ...著者: Kozicka, Z. / Suchyta, D.J. / Focht, V. / Kempf, G. / Petzold, G. / Jentzsch, M. / Zou, C. / Di Genua, C. / Donovan, K.A. / Coomar, S. / Cigler, M. / Mayor-Ruiz, C. / Schmid-Burgk, J.L. / Haussinger, D. / Winter, G.E. / Fischer, E.S. / Slabicki, M. / Gillingham, D. / Ebert, B.L. / Thoma, N.H. | ||||||||||||||||||||||||
履歴 |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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PDBx/mmCIF形式 | ![]() | 2.9 MB | 表示 | ![]() |
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PDB形式 | ![]() | 2 MB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
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-関連構造データ
関連構造データ | ![]() 8bu1C ![]() 8bu2C ![]() 8bu3C ![]() 8bu5C ![]() 8bu6C ![]() 8bu7C ![]() 8bu9C ![]() 8buaC ![]() 8bubC ![]() 8bucC ![]() 8budC ![]() 8bueC ![]() 8bufC ![]() 8bugC ![]() 8buhC ![]() 8buiC ![]() 8bujC ![]() 8bukC ![]() 8bulC ![]() 8bumC ![]() 8bunC ![]() 8buoC ![]() 8bupC ![]() 8buqC ![]() 8burC ![]() 8busC ![]() 8butC C: 同じ文献を引用 ( |
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