- PDB-8blo: Human Urea Transporter UT-A (N-Terminal Domain Model) -
+
データを開く
IDまたはキーワード:
読み込み中...
-
基本情報
登録情報
データベース: PDB / ID: 8blo
タイトル
Human Urea Transporter UT-A (N-Terminal Domain Model)
要素
Urea transporter 2
キーワード
TRANSPORT PROTEIN / SLC14A2 / UT2 / UT-A / Urea Transporter / Inhibitor / Solute Carrier
機能・相同性
機能・相同性情報
urea transport / Transport of bile salts and organic acids, metal ions and amine compounds / urea transmembrane transporter activity / urea transmembrane transport / cell adhesion molecule binding / transmembrane transport / apical plasma membrane / membrane / plasma membrane 類似検索 - 分子機能
ジャーナル: Sci Adv / 年: 2023 タイトル: Structural characterization of human urea transporters UT-A and UT-B and their inhibition. 著者: Gamma Chi / Larissa Dietz / Haiping Tang / Matthew Snee / Andreea Scacioc / Dong Wang / Gavin Mckinley / Shubhashish M M Mukhopadhyay / Ashley C W Pike / Rod Chalk / Nicola A Burgess-Brown / ...著者: Gamma Chi / Larissa Dietz / Haiping Tang / Matthew Snee / Andreea Scacioc / Dong Wang / Gavin Mckinley / Shubhashish M M Mukhopadhyay / Ashley C W Pike / Rod Chalk / Nicola A Burgess-Brown / Jean-Pierre Timmermans / Wouter van Putte / Carol V Robinson / Katharina L Dürr / 要旨: In this study, we present the structures of human urea transporters UT-A and UT-B to characterize them at molecular level and to detail the mechanism of UT-B inhibition by its selective inhibitor, ...In this study, we present the structures of human urea transporters UT-A and UT-B to characterize them at molecular level and to detail the mechanism of UT-B inhibition by its selective inhibitor, UTB-14. High-resolution structures of both transporters establish the structural basis for the inhibitor's selectivity to UT-B, and the identification of multiple binding sites for the inhibitor will aid with the development of drug lead molecules targeting both transporters. Our study also discovers phospholipids associating with the urea transporters by combining structural observations, native MS, and lipidomics analysis. These insights improve our understanding of urea transporter function at a molecular level and provide a blueprint for a structure-guided design of therapeutics targeting these transporters.
履歴
登録
2022年11月10日
登録サイト: PDBE / 処理サイト: PDBE
改定 1.0
2023年10月4日
Provider: repository / タイプ: Initial release
改定 1.0
2023年10月4日
Data content type: EM metadata / Data content type: EM metadata / Provider: repository / タイプ: Initial release
改定 1.0
2023年10月4日
Data content type: FSC / Data content type: FSC / Provider: repository / タイプ: Initial release
改定 1.0
2023年10月4日
Data content type: Half map / Part number: 1 / Data content type: Half map / Provider: repository / タイプ: Initial release
改定 1.0
2023年10月4日
Data content type: Half map / Part number: 2 / Data content type: Half map / Provider: repository / タイプ: Initial release
改定 1.0
2023年10月4日
Data content type: Image / Data content type: Image / Provider: repository / タイプ: Initial release
改定 1.0
2023年10月4日
Data content type: Mask / Data content type: Mask / Provider: repository / タイプ: Initial release
改定 1.0
2023年10月4日
Data content type: Primary map / Data content type: Primary map / Provider: repository / タイプ: Initial release
改定 1.0
2023年10月4日
Data content type: FSC / Data content type: FSC / Provider: repository / タイプ: Initial release
改定 1.0
2023年10月4日
Data content type: Half map / Part number: 1 / Data content type: Half map / Provider: repository / タイプ: Initial release
改定 1.0
2023年10月4日
Data content type: Half map / Part number: 2 / Data content type: Half map / Provider: repository / タイプ: Initial release
改定 1.0
2023年10月4日
Data content type: Image / Data content type: Image / Provider: repository / タイプ: Initial release
改定 1.0
2023年10月4日
Data content type: Mask / Data content type: Mask / Provider: repository / タイプ: Initial release
改定 1.0
2023年10月4日
Data content type: Primary map / Data content type: Primary map / Provider: repository / タイプ: Initial release
Data content type: EM metadata / Data content type: EM metadata / EM metadata / Group: Data processing / Experimental summary / Data content type: EM metadata / EM metadata / カテゴリ: em_admin / em_software / Data content type: EM metadata / EM metadata / Item: _em_admin.last_update / _em_software.name
Ureatransporter2 / Solute carrier family 14 member 2 / Urea transporter / kidney
分子量: 100124.172 Da / 分子数: 3 / 由来タイプ: 組換発現 詳細: This model is based on the N-terminal half of the protein UT-A. However, UT-A consists of two similar domains, and the map is sometimes ambiguous whether the structure is of the N-terminal or ...詳細: This model is based on the N-terminal half of the protein UT-A. However, UT-A consists of two similar domains, and the map is sometimes ambiguous whether the structure is of the N-terminal or C-terminal half. Much of the map is in line with amino acids from its N-terminal domain. 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: SLC14A2, HUT2, UT2 / 発現宿主: Homo sapiens (ヒト) / 参照: UniProt: Q15849