登録情報 | データベース: PDB / ID: 8a2h |
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タイトル | human STING in complex with 2',3'-cyclic-GMP-7-deazaphenyl-AMP |
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要素 | Stimulator of interferon genes protein |
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キーワード | PROTEIN BINDING / Complex / STING / cyclic dinucleotide |
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機能・相同性 | 機能・相同性情報
STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway ...STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway / cGAS/STING signaling pathway / reticulophagy / pattern recognition receptor signaling pathway / cytoplasmic pattern recognition receptor signaling pathway / cellular response to exogenous dsRNA / autophagosome membrane / antiviral innate immune response / positive regulation of macroautophagy / cellular response to organic cyclic compound / autophagosome assembly / autophagosome / positive regulation of type I interferon production / cellular response to interferon-beta / signaling adaptor activity / positive regulation of defense response to virus by host / activation of innate immune response / Regulation of innate immune responses to cytosolic DNA / positive regulation of interferon-beta production / endoplasmic reticulum-Golgi intermediate compartment membrane / secretory granule membrane / cytoplasmic vesicle membrane / positive regulation of DNA-binding transcription factor activity / peroxisome / SARS-CoV-1 activates/modulates innate immune responses / positive regulation of protein binding / protein complex oligomerization / regulation of inflammatory response / defense response to virus / RNA polymerase II-specific DNA-binding transcription factor binding / mitochondrial outer membrane / endosome / Golgi membrane / innate immune response / ubiquitin protein ligase binding / Neutrophil degranulation / endoplasmic reticulum membrane / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / perinuclear region of cytoplasm / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / plasma membrane / cytosol類似検索 - 分子機能 : / Stimulator of interferon genes protein / Stimulator of interferon genes protein, C-terminal domain superfamily / Transmembrane protein 173類似検索 - ドメイン・相同性 Chem-OK6 / Stimulator of interferon genes protein類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.69 Å |
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データ登録者 | Smola, M. / Vavrina, Z. / Boura, E. / Brynda, J. |
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資金援助 | European Union, 1件 組織 | 認可番号 | 国 |
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European Regional Development Fund | CZ.02.1.01/0.0/0.0/16_019/0000729 | European Union |
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引用 | ジャーナル: J.Med.Chem. / 年: 2022 タイトル: Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists. 著者: Vavrina, Z. / Perlikova, P. / Milisavljevic, N. / Chevrier, F. / Smola, M. / Smith, J. / Dejmek, M. / Havlicek, V. / Budesinsky, M. / Liboska, R. / Vanekova, L. / Brynda, J. / Boura, E. / ...著者: Vavrina, Z. / Perlikova, P. / Milisavljevic, N. / Chevrier, F. / Smola, M. / Smith, J. / Dejmek, M. / Havlicek, V. / Budesinsky, M. / Liboska, R. / Vanekova, L. / Brynda, J. / Boura, E. / Rezacova, P. / Hocek, M. / Birkus, G. |
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履歴 | 登録 | 2022年6月3日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2022年10月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年10月19日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_abbrev / _citation.journal_id_ASTM ..._citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2022年11月9日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 2.0 | 2023年5月24日 | Group: Non-polymer description / カテゴリ: chem_comp / Item: _chem_comp.formula |
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改定 2.1 | 2024年2月7日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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