Entry | Database: PDB / ID: 7zyw |
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Title | Crystal structure of T2R-TTL-PM534 complex |
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Components | - (Tubulin beta-2B ...) x 2
- Stathmin-4
- Tubulin alpha-1B chain
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Keywords | CELL CYCLE/INHIBITOR / Tubulin / microtubule destabilizing agents / inhibitor / CELL CYCLE-INHIBITOR complex |
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Function / homology | Function and homology information
tubulin-tyrosine ligase activity / positive regulation of axon guidance / microtubule depolymerization / microtubule-based process / regulation of microtubule polymerization or depolymerization / tubulin binding / Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement / protein modification process / spindle microtubule / structural constituent of cytoskeleton ...tubulin-tyrosine ligase activity / positive regulation of axon guidance / microtubule depolymerization / microtubule-based process / regulation of microtubule polymerization or depolymerization / tubulin binding / Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement / protein modification process / spindle microtubule / structural constituent of cytoskeleton / microtubule cytoskeleton organization / microtubule cytoskeleton / neuron projection development / nervous system development / mitotic cell cycle / growth cone / microtubule / neuron projection / protein heterodimerization activity / nucleotide binding / GTPase activity / GTP binding / Golgi apparatus / metal ion binding / cytoplasm / cytosolSimilarity search - Function Tubulin-tyrosine ligase/Tubulin polyglutamylase / Tubulin-tyrosine ligase family / TTL domain profile. / Stathmin family / Stathmin, conserved site / Stathmin superfamily / Stathmin family / Stathmin family signature 1. / Stathmin family signature 2. / Stathmin-like (SLD) domain profile. ...Tubulin-tyrosine ligase/Tubulin polyglutamylase / Tubulin-tyrosine ligase family / TTL domain profile. / Stathmin family / Stathmin, conserved site / Stathmin superfamily / Stathmin family / Stathmin family signature 1. / Stathmin family signature 2. / Stathmin-like (SLD) domain profile. / Tubulin-beta mRNA autoregulation signal. / Alpha tubulin / Beta tubulin, autoregulation binding site / Beta tubulin / Tubulin / Tubulin, C-terminal / Tubulin C-terminal domain / Tubulin, conserved site / Tubulin subunits alpha, beta, and gamma signature. / Tubulin/FtsZ family, C-terminal domain / Tubulin/FtsZ-like, C-terminal domain / Tubulin/FtsZ, C-terminal / Tubulin/FtsZ, 2-layer sandwich domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ, GTPase domain / Tubulin/FtsZ, GTPase domain superfamilySimilarity search - Domain/homology PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / GUANOSINE-5'-DIPHOSPHATE / GUANOSINE-5'-TRIPHOSPHATE / Chem-KG0 / Tubulin tyrosine ligase / Stathmin-4 / Tubulin alpha-1B chain / Tubulin beta-2B chainSimilarity search - Component |
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Biological species | ![](img/tx_mammal.gif) Rattus norvegicus (Norway rat)
![](img/tx_bird.gif) Gallus gallus (chicken)
![](img/tx_mammal.gif) Bos taurus (cattle) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.45 Å |
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Authors | Oliva, M.A. / Diaz, J.F. / Cuevas, C. |
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Funding support | Spain, 1items Organization | Grant number | Country |
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Ministerio de Ciencia e Innovacion (MCIN) | PID2019-104545RBI00/AEI/10.13039/501100011033 | Spain |
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Citation | Journal: J.Med.Chem. / Year: 2024 Title: PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin. Authors: Lucena-Agell, D. / Guillen, M.J. / Matesanz, R. / Alvarez-Bernad, B. / Hortiguela, R. / Aviles, P. / Martinez-Diez, M. / Santamaria-Nunez, G. / Contreras, J. / Plaza-Menacho, I. / Gimenez- ...Authors: Lucena-Agell, D. / Guillen, M.J. / Matesanz, R. / Alvarez-Bernad, B. / Hortiguela, R. / Aviles, P. / Martinez-Diez, M. / Santamaria-Nunez, G. / Contreras, J. / Plaza-Menacho, I. / Gimenez-Abian, J.F. / Oliva, M.A. / Cuevas, C. / Diaz, J.F. |
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History | Deposition | May 25, 2022 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Nov 29, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jun 12, 2024 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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