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Yorodumi- PDB-7zyq: Crystal Structure of EGFR-T790M/V948R in Complex with Reversible ... -
+Open data
-Basic information
Entry | Database: PDB / ID: 7zyq | ||||||||||||
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Title | Crystal Structure of EGFR-T790M/V948R in Complex with Reversible Aminopyrimidine 13 | ||||||||||||
Components | Epidermal growth factor receptor | ||||||||||||
Keywords | TRANSFERASE / EGFR / T790M/V948R / inhibitor | ||||||||||||
Function / homology | Function and homology information Complex I biogenesis / Respiratory electron transport / : / mitochondrial electron transport, NADH to ubiquinone / proton motive force-driven mitochondrial ATP synthesis / NADH dehydrogenase (ubiquinone) activity / aerobic respiration / electron transfer activity / mitochondrial inner membrane Similarity search - Function | ||||||||||||
Biological species | Homo sapiens (human) | ||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.1 Å | ||||||||||||
Authors | Niggenaber, J. / Mueller, M.P. / Rauh, D. | ||||||||||||
Funding support | Germany, European Union, 3items
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Citation | Journal: Acs Med.Chem.Lett. / Year: 2023 Title: Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines. Authors: Grabe, T. / Jeyakumar, K. / Niggenaber, J. / Schulz, T. / Koska, S. / Kleinbolting, S. / Beck, M.E. / Muller, M.P. / Rauh, D. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7zyq.cif.gz | 229.7 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7zyq.ent.gz | 180.8 KB | Display | PDB format |
PDBx/mmJSON format | 7zyq.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/zy/7zyq ftp://data.pdbj.org/pub/pdb/validation_reports/zy/7zyq | HTTPS FTP |
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-Related structure data
Related structure data | 7zymC 7zynC 7zypC 6s89S S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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