登録情報 | データベース: PDB / ID: 7zj1 |
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タイトル | Crystal structure of ADAR1-dsRBD3 dimer |
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要素 | Double-stranded RNA-specific adenosine deaminase |
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キーワード | RNA BINDING PROTEIN / Editing / ADAR / RNA-binding domain |
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機能・相同性 | 機能・相同性情報
somatic diversification of immune receptors via somatic mutation / negative regulation of post-transcriptional gene silencing by regulatory ncRNA / C6 deamination of adenosine / Formation of editosomes by ADAR proteins / double-stranded RNA adenine deaminase / tRNA-specific adenosine deaminase activity / supraspliceosomal complex / double-stranded RNA adenosine deaminase activity / negative regulation of protein kinase activity by regulation of protein phosphorylation / base conversion or substitution editing ...somatic diversification of immune receptors via somatic mutation / negative regulation of post-transcriptional gene silencing by regulatory ncRNA / C6 deamination of adenosine / Formation of editosomes by ADAR proteins / double-stranded RNA adenine deaminase / tRNA-specific adenosine deaminase activity / supraspliceosomal complex / double-stranded RNA adenosine deaminase activity / negative regulation of protein kinase activity by regulation of protein phosphorylation / base conversion or substitution editing / hematopoietic stem cell homeostasis / response to interferon-alpha / adenosine to inosine editing / RISC complex assembly / negative regulation of hepatocyte apoptotic process / pre-miRNA processing / definitive hemopoiesis / negative regulation of type I interferon-mediated signaling pathway / hepatocyte apoptotic process / positive regulation of viral genome replication / RNA processing / hematopoietic progenitor cell differentiation / protein export from nucleus / erythrocyte differentiation / response to virus / PKR-mediated signaling / mRNA processing / cellular response to virus / osteoblast differentiation / protein import into nucleus / Interferon alpha/beta signaling / double-stranded RNA binding / defense response to virus / innate immune response / nucleolus / DNA binding / RNA binding / nucleoplasm / membrane / nucleus / metal ion binding / cytoplasm / cytosol類似検索 - 分子機能 ADAR1, first double-stranded RNA binding domain / ADAR1, third double-stranded RNA binding domain / Z-DNA-binding domain in adenosine deaminases. / Adenosine deaminase/editase / Adenosine-deaminase (editase) domain / Z-binding domain profile. / Adenosine to inosine editase domain profile. / tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) / Z-binding domain / Adenosine deaminase z-alpha domain ...ADAR1, first double-stranded RNA binding domain / ADAR1, third double-stranded RNA binding domain / Z-DNA-binding domain in adenosine deaminases. / Adenosine deaminase/editase / Adenosine-deaminase (editase) domain / Z-binding domain profile. / Adenosine to inosine editase domain profile. / tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase) / Z-binding domain / Adenosine deaminase z-alpha domain / Double-stranded RNA binding motif / Double-stranded RNA binding motif / Double stranded RNA-binding domain (dsRBD) profile. / Double-stranded RNA-binding domain / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily類似検索 - ドメイン・相同性 Double-stranded RNA-specific adenosine deaminase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.65 Å |
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データ登録者 | Mboukou, A. / Barraud, P. |
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資金援助 | フランス, 1件 組織 | 認可番号 | 国 |
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Agence Nationale de la Recherche (ANR) | ANR-16-CE91-0003 | フランス |
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引用 | ジャーナル: Biorxiv / 年: 2023 タイトル: Dimerization of ADAR1 modulates site-specificity of RNA editing 著者: Mboukou, A. / Rajendra, V. / Messmer, S. / Catala, M. / Tisne, C. / Jantsch, M.F. / Barraud, P. |
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履歴 | 登録 | 2022年4月8日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2023年10月25日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年12月13日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.title / _citation.year |
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改定 1.2 | 2023年12月20日 | Group: Database references / Structure summary / カテゴリ: pdbx_database_related / struct / Item: _struct.title |
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