Entry Database : PDB / ID : 7zit Structure visualization Downloads & linksTitle 14-3-3 in complex with SARS-COV2 N phospho-peptide Components14-3-3 protein zeta/delta Nucleoprotein DetailsKeywords PROTEIN BINDING / covid / coronavirus / N-phosphopeptideFunction / homology Function and homology informationFunction Domain/homology Component
: / synaptic target recognition / Golgi reassembly / response to host immune response / NOTCH4 Activation and Transmission of Signal to the Nucleus / viral RNA genome packaging / establishment of Golgi localization / respiratory system process / negative regulation of interferon-beta production / tube formation ... : / synaptic target recognition / Golgi reassembly / response to host immune response / NOTCH4 Activation and Transmission of Signal to the Nucleus / viral RNA genome packaging / establishment of Golgi localization / respiratory system process / negative regulation of interferon-beta production / tube formation / regulation of synapse maturation / Rap1 signalling / negative regulation of protein localization to nucleus / poly(U) RNA binding / Maturation of nucleoprotein / intracellular membraneless organelle / KSRP (KHSRP) binds and destabilizes mRNA / GP1b-IX-V activation signalling / positive regulation of NLRP3 inflammasome complex assembly / MHC class I protein binding / Regulation of localization of FOXO transcription factors / Interleukin-3, Interleukin-5 and GM-CSF signaling / phosphoserine residue binding / CD28 dependent PI3K/Akt signaling / Activation of BAD and translocation to mitochondria / protein targeting / regulation of ERK1 and ERK2 cascade / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / cellular response to glucose starvation / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / RHO GTPases activate PKNs / negative regulation of TORC1 signaling / ERK1 and ERK2 cascade / Transcriptional and post-translational regulation of MITF-M expression and activity / protein sequestering activity / negative regulation of innate immune response / hippocampal mossy fiber to CA3 synapse / VEGFR2 mediated vascular permeability / Translocation of SLC2A4 (GLUT4) to the plasma membrane / TP53 Regulates Metabolic Genes / Deactivation of the beta-catenin transactivating complex / lung development / Negative regulation of NOTCH4 signaling / molecular condensate scaffold activity / TAK1-dependent IKK and NF-kappa-B activation / NOD1/2 Signaling Pathway / DDX58/IFIH1-mediated induction of interferon-alpha/beta / regulation of protein stability / MHC class I protein complex / RNA stem-loop binding / Interleukin-1 signaling / Interferon alpha/beta signaling / viral capsid / melanosome / intracellular protein localization / PIP3 activates AKT signaling / Transcription of SARS-CoV-2 sgRNAs / host cell endoplasmic reticulum-Golgi intermediate compartment / viral nucleocapsid / angiogenesis / protein phosphatase binding / host cell Golgi apparatus / blood microparticle / vesicle / DNA-binding transcription factor binding / Translation of Structural Proteins / Virion Assembly and Release / host extracellular space / Induction of Cell-Cell Fusion / transmembrane transporter binding / Attachment and Entry / host cell perinuclear region of cytoplasm / protein phosphorylation / cadherin binding / ribonucleoprotein complex / protein domain specific binding / focal adhesion / ubiquitin protein ligase binding / negative regulation of apoptotic process / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / glutamatergic synapse / negative regulation of transcription by RNA polymerase II / signal transduction / protein homodimerization activity / extracellular space / RNA binding / extracellular exosome / extracellular region / nucleoplasm / identical protein binding / nucleus / cytosol / cytoplasm Similarity search - Function Nucleocapsid protein, betacoronavirus / Nucleocapsid protein, coronavirus / Nucleocapsid protein, C-terminal / Nucleocapsid protein, N-terminal / Nucleocapsid (N) protein, C-terminal domain, coronavirus / Nucleocapsid (N) protein, N-terminal domain, coronavirus / Coronavirus nucleocapsid / Coronavirus nucleocapsid (CoV N) protein N-terminal (NTD) domain profile. / Coronavirus nucleocapsid (CoV N) protein C-terminal (CTD) domain profile. / 14-3-3 domain ... Nucleocapsid protein, betacoronavirus / Nucleocapsid protein, coronavirus / Nucleocapsid protein, C-terminal / Nucleocapsid protein, N-terminal / Nucleocapsid (N) protein, C-terminal domain, coronavirus / Nucleocapsid (N) protein, N-terminal domain, coronavirus / Coronavirus nucleocapsid / Coronavirus nucleocapsid (CoV N) protein N-terminal (NTD) domain profile. / Coronavirus nucleocapsid (CoV N) protein C-terminal (CTD) domain profile. / 14-3-3 domain / Delta-Endotoxin; domain 1 / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human) Severe acute respiratory syndrome coronavirus 2Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 1.79 Å DetailsAuthors Eisenreichova, A. / Boura, E. Funding support Czech Republic, 1items Details Hide detailsOrganization Grant number Country Czech Academy of Sciences 61388963 Czech Republic
CitationJournal : J.Struct.Biol. / Year : 2022Title : Structural basis for SARS-CoV-2 nucleocapsid (N) protein recognition by 14-3-3 proteins.Authors : Eisenreichova, A. / Boura, E. History Deposition Apr 8, 2022 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 26, 2022 Provider : repository / Type : Initial releaseRevision 1.1 Jan 31, 2024 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_modelRevision 1.2 Oct 23, 2024 Group : Structure summary / Category : pdbx_entry_details / pdbx_modification_feature / Item : _pdbx_entry_details.has_protein_modification
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