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- PDB-7y1p: CRYSTAL STRUCTURE OF THE RGS-HOMOLOGOUS DOMAIN OF AXIN IN COMPLEX... -
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Basic information
Entry | Database: PDB / ID: 7y1p | |||||||||
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Title | CRYSTAL STRUCTURE OF THE RGS-HOMOLOGOUS DOMAIN OF AXIN IN COMPLEX WITH LZ-22Na | |||||||||
![]() | Axin-1 | |||||||||
![]() | SIGNALING PROTEIN / Wint/beta-catenin signaling pathway | |||||||||
Function / homology | ![]() armadillo repeat domain binding / head development / cell development / dorsal/ventral axis specification / axial mesoderm formation / post-anal tail morphogenesis / APC truncation mutants have impaired AXIN binding / AXIN missense mutants destabilize the destruction complex / Truncations of AMER1 destabilize the destruction complex / beta-catenin destruction complex ...armadillo repeat domain binding / head development / cell development / dorsal/ventral axis specification / axial mesoderm formation / post-anal tail morphogenesis / APC truncation mutants have impaired AXIN binding / AXIN missense mutants destabilize the destruction complex / Truncations of AMER1 destabilize the destruction complex / beta-catenin destruction complex / epigenetic programming in the zygotic pronuclei / positive regulation of ubiquitin-dependent protein catabolic process / Beta-catenin phosphorylation cascade / Signaling by GSK3beta mutants / CTNNB1 S33 mutants aren't phosphorylated / CTNNB1 S37 mutants aren't phosphorylated / CTNNB1 S45 mutants aren't phosphorylated / CTNNB1 T41 mutants aren't phosphorylated / I-SMAD binding / Wnt signalosome / Disassembly of the destruction complex and recruitment of AXIN to the membrane / nucleocytoplasmic transport / negative regulation of protein metabolic process / RUNX1 regulates transcription of genes involved in WNT signaling / RUNX1 regulates estrogen receptor mediated transcription / negative regulation of fat cell differentiation / activation of protein kinase activity / positive regulation of transforming growth factor beta receptor signaling pathway / negative regulation of transcription elongation by RNA polymerase II / SMAD binding / R-SMAD binding / ubiquitin-like ligase-substrate adaptor activity / lateral plasma membrane / canonical Wnt signaling pathway / signaling adaptor activity / cytoplasmic microtubule organization / positive regulation of peptidyl-threonine phosphorylation / positive regulation of protein ubiquitination / TCF dependent signaling in response to WNT / cell periphery / Degradation of AXIN / positive regulation of JNK cascade / sensory perception of sound / Degradation of beta-catenin by the destruction complex / negative regulation of canonical Wnt signaling pathway / beta-catenin binding / protein polyubiquitination / positive regulation of protein catabolic process / : / microtubule cytoskeleton / p53 binding / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / positive regulation of peptidyl-serine phosphorylation / cell cortex / cytoplasmic vesicle / protein-containing complex assembly / proteasome-mediated ubiquitin-dependent protein catabolic process / Estrogen-dependent gene expression / in utero embryonic development / molecular adaptor activity / Ub-specific processing proteases / positive regulation of protein phosphorylation / negative regulation of gene expression / apoptotic process / ubiquitin protein ligase binding / nucleolus / protein kinase binding / perinuclear region of cytoplasm / enzyme binding / protein homodimerization activity / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function | |||||||||
Biological species | ![]() | |||||||||
Method | ![]() ![]() ![]() | |||||||||
![]() | He, Z. / Yuchi, Z. | |||||||||
Funding support | ![]()
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![]() | ![]() Title: CRYSTAL STRUCTURE OF THE RGS-HOMOLOGOUS DOMAIN OF AXIN IN COMPLEX WITH LZ-22Na Authors: He, Z. / Yuchi, Z. | |||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 121.2 KB | Display | ![]() |
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PDB format | ![]() | 93.6 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 787.6 KB | Display | ![]() |
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Full document | ![]() | 797.7 KB | Display | |
Data in XML | ![]() | 21.6 KB | Display | |
Data in CIF | ![]() | 29 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 1dk8S S: Starting model for refinement |
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Similar structure data | Similarity search - Function & homology ![]() |
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Assembly
Deposited unit | ![]()
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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