+Open data
-Basic information
Entry | Database: PDB / ID: 7xjb | |||||||||
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Title | Rat-COMT, opicapone,SAM and Mg bond | |||||||||
Components | Catechol O-methyltransferaseCatechol-O-methyltransferase | |||||||||
Keywords | TRANSFERASE / Enzyme S-adenosylmethionone catechol / catecholamine | |||||||||
Function / homology | Function and homology information Enzymatic degradation of dopamine by COMT / Enzymatic degradation of Dopamine by monoamine oxidase / positive regulation of homocysteine metabolic process / Methylation / norepinephrine secretion / response to dopamine / mastication / catecholamine catabolic process / catechol-containing compound metabolic process / S-adenosylhomocysteine metabolic process ...Enzymatic degradation of dopamine by COMT / Enzymatic degradation of Dopamine by monoamine oxidase / positive regulation of homocysteine metabolic process / Methylation / norepinephrine secretion / response to dopamine / mastication / catecholamine catabolic process / catechol-containing compound metabolic process / S-adenosylhomocysteine metabolic process / response to salt / catechol O-methyltransferase activity / renal sodium excretion / : / : / renin secretion into blood stream / catechol O-methyltransferase / developmental process / renal filtration / renal albumin absorption / dopamine secretion / S-adenosylmethionine metabolic process / negative regulation of dopamine metabolic process / habituation / artery development / catecholamine metabolic process / short-term memory / cellular response to phosphate starvation / cerebellar cortex morphogenesis / dopamine catabolic process / norepinephrine metabolic process / glomerulus development / fear response / multicellular organismal reproductive process / synaptic transmission, dopaminergic / response to angiotensin / cellular response to cocaine / estrogen metabolic process / response to food / exploration behavior / cholesterol efflux / response to temperature stimulus / response to pain / dopamine metabolic process / response to corticosterone / prostaglandin metabolic process / glycogen metabolic process / startle response / detection of temperature stimulus involved in sensory perception of pain / response to inorganic substance / behavioral fear response / multicellular organismal response to stress / response to amphetamine / response to organic substance / kidney development / learning / female pregnancy / response to cytokine / negative regulation of smooth muscle cell proliferation / multicellular organism growth / visual learning / response to organic cyclic compound / memory / response to toxic substance / cognition / regulation of blood pressure / response to wounding / response to estrogen / cell body / gene expression / methylation / postsynapse / postsynaptic membrane / response to oxidative stress / vesicle / response to lipopolysaccharide / dendritic spine / response to hypoxia / learning or memory / response to xenobiotic stimulus / axon / dendrite / glutamatergic synapse / magnesium ion binding / membrane / cytosol Similarity search - Function | |||||||||
Biological species | Rattus norvegicus (Norway rat) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.6 Å | |||||||||
Authors | Takebe, K. / Iijima, H. / Suzuki, M. / Kuwada-Kusunose, T. | |||||||||
Funding support | Japan, 2items
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Citation | Journal: J.Chem.Inf.Model. / Year: 2023 Title: Structural and Computational Analyses of the Unique Interactions of Opicapone in the Binding Pocket of Catechol O -Methyltransferase: A Crystallographic Study and Fragment Molecular Orbital Analyses. Authors: Takebe, K. / Suzuki, M. / Kuwada-Kusunose, T. / Shirai, S. / Fukuzawa, K. / Takamiya, T. / Uzawa, N. / Iijima, H. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7xjb.cif.gz | 353.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7xjb.ent.gz | 286.6 KB | Display | PDB format |
PDBx/mmJSON format | 7xjb.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/xj/7xjb ftp://data.pdbj.org/pub/pdb/validation_reports/xj/7xjb | HTTPS FTP |
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-Related structure data
Related structure data | 7xgiC 6lfeS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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