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Yorodumi- PDB-7xh3: Dimeric G-quadruplex DNA Formed in the Proximal Promoter of VEGFR-2 -
+Open data
-Basic information
Entry | Database: PDB / ID: 7xh3 | ||||||||||||||||||||||||||||
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Title | Dimeric G-quadruplex DNA Formed in the Proximal Promoter of VEGFR-2 | ||||||||||||||||||||||||||||
Components | DNA (5'-D(*Keywords | DNA / Dimeric G-quadruplex DNA Formed in the Proximal Promoter of VEGFR-2 | Function / homology | DNA / DNA (> 10) | Function and homology information Biological species | DNA molecule (others) | Method | SOLUTION NMR / distance geometry | Authors | Zhang, Y. / Lan, W. / Wang, C. / Cao, C. | Funding support | China, 1items |
Citation | Journal: Chin.J.Chem. / Year: 2022 | Title: Dimeric G-quadruplex DNA Structure in the Proximal Promoter of VEGFR-2 Reveals a New Drug Target to Inhibit Tumor Angiogenesis. Authors: Zhang, Y. / Lan, W. / Wang, C. / Xue, H. / Cao, C. History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7xh3.cif.gz | 288.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7xh3.ent.gz | 241.8 KB | Display | PDB format |
PDBx/mmJSON format | 7xh3.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7xh3_validation.pdf.gz | 315.6 KB | Display | wwPDB validaton report |
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Full document | 7xh3_full_validation.pdf.gz | 389.1 KB | Display | |
Data in XML | 7xh3_validation.xml.gz | 5.9 KB | Display | |
Data in CIF | 7xh3_validation.cif.gz | 11.5 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/xh/7xh3 ftp://data.pdbj.org/pub/pdb/validation_reports/xh/7xh3 | HTTPS FTP |
-Related structure data
Related structure data | 7xfvC C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
Other databases |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: DNA chain | Mass: 3664.380 Da / Num. of mol.: 2 / Source method: obtained synthetically / Source: (synth.) DNA molecule (others) |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||
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NMR experiment |
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-Sample preparation
Details | Type: solution / Contents: 2.0 mM VEGFR-ds, 90% H2O/10% D2O / Label: none / Solvent system: 90% H2O/10% D2O |
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Sample | Conc.: 2.0 mM / Component: VEGFR-ds / Isotopic labeling: none |
Sample conditions | Ionic strength: 100 mM / Label: 1 / pH: 6.8 / Pressure: 1 atm / Temperature: 293 K |
-NMR measurement
NMR spectrometer |
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-Processing
NMR software |
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Refinement | Method: distance geometry / Software ordinal: 1 | ||||||||||||
NMR representative | Selection criteria: lowest energy | ||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 100 / Conformers submitted total number: 20 |