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- PDB-7xh3: Dimeric G-quadruplex DNA Formed in the Proximal Promoter of VEGFR-2 -
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Open data
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Basic information
Entry | Database: PDB / ID: 7xh3 | ||||||||||||||||||||||||||||
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Title | Dimeric G-quadruplex DNA Formed in the Proximal Promoter of VEGFR-2 | ||||||||||||||||||||||||||||
![]() | DNA (5'-D(*![]() DNA / Dimeric G-quadruplex DNA Formed in the Proximal Promoter of VEGFR-2 | Function / homology | DNA / DNA (> 10) | ![]() Biological species | DNA molecule (others) | Method | SOLUTION NMR / distance geometry | ![]() Zhang, Y. / Lan, W. / Wang, C. / Cao, C. | Funding support | | ![]()
![]() ![]() Title: Dimeric G-quadruplex DNA Structure in the Proximal Promoter of VEGFR-2 Reveals a New Drug Target to Inhibit Tumor Angiogenesis. Authors: Zhang, Y. / Lan, W. / Wang, C. / Xue, H. / Cao, C. History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 288.2 KB | Display | ![]() |
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PDB format | ![]() | 241.8 KB | Display | ![]() |
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-Validation report
Summary document | ![]() | 315.6 KB | Display | ![]() |
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Full document | ![]() | 389.1 KB | Display | |
Data in XML | ![]() | 5.9 KB | Display | |
Data in CIF | ![]() | 11.5 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 7xfvC C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
Other databases |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: DNA chain | Mass: 3664.380 Da / Num. of mol.: 2 / Source method: obtained synthetically / Source: (synth.) DNA molecule (others) |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||
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NMR experiment |
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Sample preparation
Details | Type: solution / Contents: 2.0 mM VEGFR-ds, 90% H2O/10% D2O / Label: none / Solvent system: 90% H2O/10% D2O |
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Sample | Conc.: 2.0 mM / Component: VEGFR-ds / Isotopic labeling: none |
Sample conditions | Ionic strength: 100 mM / Label: 1 / pH: 6.8 / Pressure: 1 atm / Temperature: 293 K |
-NMR measurement
NMR spectrometer |
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Processing
NMR software |
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Refinement | Method: distance geometry / Software ordinal: 1 | ||||||||||||
NMR representative | Selection criteria: lowest energy | ||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 100 / Conformers submitted total number: 20 |