登録情報 データベース : PDB / ID : 7wxx 構造の表示 ダウンロードとリンクタイトル Crystal structure of human MMP-7 in complex with inhibitor 要素Matrilysin Peptide Inhibitor 詳細キーワード HYDROLASE / Matrilysin / Matrin / Matrix metalloproteinase-7 / Pump-1 protease / Uterine metalloproteinase機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
matrilysin / antibacterial peptide secretion / antibacterial peptide biosynthetic process / membrane protein intracellular domain proteolysis / Assembly of collagen fibrils and other multimeric structures / Activation of Matrix Metalloproteinases / membrane protein ectodomain proteolysis / Collagen degradation / collagen catabolic process / extracellular matrix disassembly ... matrilysin / antibacterial peptide secretion / antibacterial peptide biosynthetic process / membrane protein intracellular domain proteolysis / Assembly of collagen fibrils and other multimeric structures / Activation of Matrix Metalloproteinases / membrane protein ectodomain proteolysis / Collagen degradation / collagen catabolic process / extracellular matrix disassembly / Degradation of the extracellular matrix / extracellular matrix organization / extracellular matrix / metalloendopeptidase activity / metallopeptidase activity / regulation of cell population proliferation / defense response to Gram-negative bacterium / endopeptidase activity / Extra-nuclear estrogen signaling / defense response to Gram-positive bacterium / positive regulation of cell migration / response to xenobiotic stimulus / serine-type endopeptidase activity / proteolysis / extracellular space / zinc ion binding / extracellular exosome / extracellular region 類似検索 - 分子機能 Peptidoglycan binding-like / Peptidase M10A, cysteine switch, zinc binding site / Matrixins cysteine switch. / Putative peptidoglycan binding domain / Peptidase M10A / Peptidase M10A, catalytic domain / Peptidase M10, metallopeptidase / Matrixin / PGBD-like superfamily / Peptidase, metallopeptidase ... Peptidoglycan binding-like / Peptidase M10A, cysteine switch, zinc binding site / Matrixins cysteine switch. / Putative peptidoglycan binding domain / Peptidase M10A / Peptidase M10A, catalytic domain / Peptidase M10, metallopeptidase / Matrixin / PGBD-like superfamily / Peptidase, metallopeptidase / Zinc-dependent metalloprotease / Metallopeptidase, catalytic domain superfamily / Neutral zinc metallopeptidases, zinc-binding region signature. 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)synthetic construct (人工物) 手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.5 Å 詳細データ登録者 Kamitani, M. / Oka, Y. / Tabuse, H. 資金援助 1件 詳細 詳細を隠す 引用ジャーナル : J.Med.Chem. / 年 : 2022タイトル : Discovery of Highly Potent and Selective Matrix Metalloproteinase-7 Inhibitors by Hybridizing the S1' Subsite Binder with Short Peptides.著者 : Tabuse, H. / Abe-Sato, K. / Kanazawa, H. / Yashiro, M. / Tamura, Y. / Kamitani, M. / Hitaka, K. / Gunji, E. / Mitani, A. / Kojima, N. / Oka, Y. 履歴 登録 2022年2月15日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2022年10月5日 Provider : repository / タイプ : Initial release改定 1.1 2022年10月26日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID 改定 2.0 2023年11月15日 Group : Atomic model / Data collection / Derived calculationsカテゴリ : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / pdbx_validate_peptide_omega / struct_conn Item : _atom_site.auth_atom_id / _atom_site.label_atom_id ... _atom_site.auth_atom_id / _atom_site.label_atom_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr2_label_atom_id 改定 2.1 2023年11月29日 Group : Refinement description / カテゴリ : pdbx_initial_refinement_model
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