登録情報 | データベース: PDB / ID: 7wdg |
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タイトル | Crystal structure of the P450 BM3 heme domain mutant F87L in complex with N-imidazolyl-hexanoyl-L-phenylalanine, phenol and hydroxylamine |
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要素 | Bifunctional cytochrome P450/NADPH--P450 reductase |
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キーワード | OXIDOREDUCTASE / Dual-functional small molecule / P450 heme domain / Complex |
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機能・相同性 | 機能・相同性情報
NADPH-hemoprotein reductase / NADPH-hemoprotein reductase activity / unspecific monooxygenase / aromatase activity / response to hormone / FMN binding / flavin adenine dinucleotide binding / iron ion binding / heme binding / cytosol類似検索 - 分子機能 Bifunctional cytochrome P450/NADPH--cytochrome P450 reductase / Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding / NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily / FAD binding domain / Flavodoxin-like / Flavoprotein pyridine nucleotide cytochrome reductase / Flavodoxin / Flavodoxin-like domain profile. / Flavodoxin/nitric oxide synthase / Oxidoreductase FAD/NAD(P)-binding ...Bifunctional cytochrome P450/NADPH--cytochrome P450 reductase / Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding / NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily / FAD binding domain / Flavodoxin-like / Flavoprotein pyridine nucleotide cytochrome reductase / Flavodoxin / Flavodoxin-like domain profile. / Flavodoxin/nitric oxide synthase / Oxidoreductase FAD/NAD(P)-binding / Oxidoreductase NAD-binding domain / FAD-binding domain, ferredoxin reductase-type / Ferredoxin-NADP reductase (FNR), nucleotide-binding domain / Ferredoxin reductase-type FAD binding domain profile. / Riboflavin synthase-like beta-barrel / Cytochrome P450, conserved site / Cytochrome P450 cysteine heme-iron ligand signature. / Flavoprotein-like superfamily / Cytochrome P450 / Cytochrome P450 superfamily / Cytochrome P450類似検索 - ドメイン・相同性 PROTOPORPHYRIN IX CONTAINING FE / HYDROXYAMINE / Chem-IC6 / PHENOL / Bifunctional cytochrome P450/NADPH--P450 reductase類似検索 - 構成要素 |
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生物種 | Priestia megaterium (バクテリア) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.07 Å |
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データ登録者 | Jiang, Y. / Dong, S. / Feng, Y. / Cong, Z. |
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資金援助 | 中国, 2件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 21778060 | 中国 | National Natural Science Foundation of China (NSFC) | 21977104 | 中国 |
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引用 | ジャーナル: Angew.Chem.Int.Ed.Engl. / 年: 2023 タイトル: Engineering Cytochrome P450BM3 Enzymes for Direct Nitration of Unsaturated Hydrocarbons. 著者: Wang, X. / Lin, X. / Jiang, Y. / Qin, X. / Ma, N. / Yao, F. / Dong, S. / Liu, C. / Feng, Y. / Jin, L. / Xian, M. / Cong, Z. |
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履歴 | 登録 | 2021年12月21日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2022年12月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年7月19日 | Group: Database references / Refinement description カテゴリ: citation / citation_author / struct_ncs_dom_lim Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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改定 1.2 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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