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Yorodumi- PDB-7vmv: Crystal structure of Dengue NS2B-NS3 Protease after secondary cleavage -
+Open data
-Basic information
Entry | Database: PDB / ID: 7vmv | ||||||
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Title | Crystal structure of Dengue NS2B-NS3 Protease after secondary cleavage | ||||||
Components | (Core proteinCapsid) x 2 | ||||||
Keywords | VIRAL PROTEIN / NS3 Protease | ||||||
Function / homology | Function and homology information symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / viral capsid / double-stranded RNA binding / clathrin-dependent endocytosis of virus by host cell / mRNA (nucleoside-2'-O-)-methyltransferase activity / mRNA 5'-cap (guanine-N7-)-methyltransferase activity / RNA helicase activity / host cell endoplasmic reticulum membrane ...symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / viral capsid / double-stranded RNA binding / clathrin-dependent endocytosis of virus by host cell / mRNA (nucleoside-2'-O-)-methyltransferase activity / mRNA 5'-cap (guanine-N7-)-methyltransferase activity / RNA helicase activity / host cell endoplasmic reticulum membrane / membrane => GO:0016020 / protein dimerization activity / viral RNA genome replication / RNA-dependent RNA polymerase activity / serine-type endopeptidase activity / fusion of virus membrane with host endosome membrane / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / host cell nucleus / structural molecule activity / virion attachment to host cell / virion membrane / ATP hydrolysis activity / extracellular region / ATP binding / metal ion binding Similarity search - Function | ||||||
Biological species | Dengue virus 4 | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.351 Å | ||||||
Authors | Quek, J.P. | ||||||
Funding support | Singapore, 1items
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Citation | Journal: Viruses / Year: 2022 Title: Dynamic Interactions of Post Cleaved NS2B Cofactor and NS3 Protease Identified by Integrative Structural Approaches. Authors: Quek, J.P. / Ser, Z. / Chew, B.L.A. / Li, X. / Wang, L. / Sobota, R.M. / Luo, D. / Phoo, W.W. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7vmv.cif.gz | 332.3 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7vmv.ent.gz | 271.2 KB | Display | PDB format |
PDBx/mmJSON format | 7vmv.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/vm/7vmv ftp://data.pdbj.org/pub/pdb/validation_reports/vm/7vmv | HTTPS FTP |
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-Related structure data
Related structure data | 2vbcS S: Starting model for refinement |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
Deposited unit |
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3 |
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4 |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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