登録情報 | データベース: PDB / ID: 7ut0 |
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タイトル | Human DDAH-1, apo form |
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要素 | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 |
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キーワード | HYDROLASE / Cardiovascular enzyme / Proton pump inhibitors / Esomeprazole |
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機能・相同性 | 機能・相同性情報
dimethylargininase / dimethylargininase activity / citrulline metabolic process / negative regulation of cellular response to hypoxia / arginine metabolic process / regulation of systemic arterial blood pressure / negative regulation of vascular permeability / nitric oxide metabolic process / amino acid binding / catalytic activity ...dimethylargininase / dimethylargininase activity / citrulline metabolic process / negative regulation of cellular response to hypoxia / arginine metabolic process / regulation of systemic arterial blood pressure / negative regulation of vascular permeability / nitric oxide metabolic process / amino acid binding / catalytic activity / nitric oxide mediated signal transduction / eNOS activation / arginine catabolic process / positive regulation of angiogenesis / positive regulation of nitric oxide biosynthetic process / negative regulation of cell population proliferation / extracellular exosome / metal ion binding / cytosol類似検索 - 分子機能 Dimethylarginine dimethylaminohydrolase / N,N dimethylarginine dimethylhydrolase, eukaryotic類似検索 - ドメイン・相同性 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.68 Å |
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データ登録者 | Smith, C.A. / Ghebre, Y.T. |
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資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS) | R56AR077445 | 米国 | National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) | K01HL118683 | 米国 | National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) | R01HL137703 | 米国 |
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引用 | ジャーナル: Biochim Biophys Acta Gen Subj / 年: 2022 タイトル: Esomeprazole covalently interacts with the cardiovascular enzyme dimethylarginine dimethylaminohydrolase: Insights into the cardiovascular risk of proton pump inhibitors. 著者: Smith, C.A. / Ebrahimpour, A. / Novikova, L. / Farina, D. / Bailey, A.O. / Russell, W.K. / Jain, A. / Saltzman, A.B. / Malovannaya, A. / Prasad, B.V.V. / Hu, L. / Ghebre, Y.T. |
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履歴 | 登録 | 2022年4月26日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年5月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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