- PDB-7urz: Hexadecameric hub domain of CaMKII beta -
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Basic information
Entry
Database: PDB / ID: 7urz
Title
Hexadecameric hub domain of CaMKII beta
Components
Calcium/calmodulin-dependent protein kinase type II subunit beta
Keywords
TRANSFERASE / CaMKII / Kinase / Human / CAMK2B
Function / homology
Function and homology information
regulation of skeletal muscle adaptation / regulation of synapse structural plasticity / calcium- and calmodulin-dependent protein kinase complex / positive regulation of synapse maturation / regulation of dendritic spine development / regulation of neuron migration / Ca2+/calmodulin-dependent protein kinase / positive regulation of dendritic spine morphogenesis / calcium-dependent protein serine/threonine kinase activity / Trafficking of AMPA receptors ...regulation of skeletal muscle adaptation / regulation of synapse structural plasticity / calcium- and calmodulin-dependent protein kinase complex / positive regulation of synapse maturation / regulation of dendritic spine development / regulation of neuron migration / Ca2+/calmodulin-dependent protein kinase / positive regulation of dendritic spine morphogenesis / calcium-dependent protein serine/threonine kinase activity / Trafficking of AMPA receptors / Assembly and cell surface presentation of NMDA receptors / calcium/calmodulin-dependent protein kinase activity / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / CaMK IV-mediated phosphorylation of CREB / Negative regulation of NMDA receptor-mediated neuronal transmission / Unblocking of NMDA receptors, glutamate binding and activation / Phase 0 - rapid depolarisation / regulation of calcium ion transport / Ion transport by P-type ATPases / Long-term potentiation / Regulation of MECP2 expression and activity / HSF1-dependent transactivation / Ion homeostasis / sarcoplasmic reticulum membrane / Ras activation upon Ca2+ influx through NMDA receptor / RAF activation / regulation of long-term neuronal synaptic plasticity / positive regulation of neuron projection development / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / endocytic vesicle membrane / Interferon gamma signaling / Signaling by BRAF and RAF1 fusions / nervous system development / actin binding / RAF/MAP kinase cascade / peptidyl-serine phosphorylation / protein autophosphorylation / cell differentiation / calmodulin binding / neuron projection / protein phosphorylation / protein serine kinase activity / centrosome / synapse / signal transduction / protein homodimerization activity / nucleoplasm / ATP binding / identical protein binding / cytoplasm / cytosol Similarity search - Function
Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / NTF2-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. ...Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / NTF2-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homology
G: Calcium/calmodulin-dependent protein kinase type II subunit beta A: Calcium/calmodulin-dependent protein kinase type II subunit beta B: Calcium/calmodulin-dependent protein kinase type II subunit beta C: Calcium/calmodulin-dependent protein kinase type II subunit beta
G: Calcium/calmodulin-dependent protein kinase type II subunit beta A: Calcium/calmodulin-dependent protein kinase type II subunit beta B: Calcium/calmodulin-dependent protein kinase type II subunit beta C: Calcium/calmodulin-dependent protein kinase type II subunit beta
G: Calcium/calmodulin-dependent protein kinase type II subunit beta A: Calcium/calmodulin-dependent protein kinase type II subunit beta B: Calcium/calmodulin-dependent protein kinase type II subunit beta C: Calcium/calmodulin-dependent protein kinase type II subunit beta
G: Calcium/calmodulin-dependent protein kinase type II subunit beta A: Calcium/calmodulin-dependent protein kinase type II subunit beta B: Calcium/calmodulin-dependent protein kinase type II subunit beta C: Calcium/calmodulin-dependent protein kinase type II subunit beta
G: Calcium/calmodulin-dependent protein kinase type II subunit beta A: Calcium/calmodulin-dependent protein kinase type II subunit beta B: Calcium/calmodulin-dependent protein kinase type II subunit beta C: Calcium/calmodulin-dependent protein kinase type II subunit beta
Resolution: 3.45→37.09 Å / Cor.coef. Fo:Fc: 0.812 / Cor.coef. Fo:Fc free: 0.712 / SU B: 61.406 / SU ML: 0.901 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R Free: 1.012 / Stereochemistry target values: MAXIMUM LIKELIHOOD Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.4074
424
5.1 %
RANDOM
Rwork
0.3516
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-
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obs
0.3544
7921
97.75 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK
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