- PDB-7urw: Tetradecameric hub domain of CaMKII beta -
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基本情報
登録情報
データベース: PDB / ID: 7urw
タイトル
Tetradecameric hub domain of CaMKII beta
要素
Calcium/calmodulin-dependent protein kinase type II subunit beta
キーワード
TRANSFERASE / CaMKII / Kinase / Human / CAMK2B
機能・相同性
機能・相同性情報
regulation of skeletal muscle adaptation / regulation of synapse structural plasticity / calcium- and calmodulin-dependent protein kinase complex / positive regulation of synapse maturation / regulation of dendritic spine development / regulation of neuron migration / Ca2+/calmodulin-dependent protein kinase / positive regulation of dendritic spine morphogenesis / calcium-dependent protein serine/threonine kinase activity / Trafficking of AMPA receptors ...regulation of skeletal muscle adaptation / regulation of synapse structural plasticity / calcium- and calmodulin-dependent protein kinase complex / positive regulation of synapse maturation / regulation of dendritic spine development / regulation of neuron migration / Ca2+/calmodulin-dependent protein kinase / positive regulation of dendritic spine morphogenesis / calcium-dependent protein serine/threonine kinase activity / Trafficking of AMPA receptors / Assembly and cell surface presentation of NMDA receptors / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / calmodulin-dependent protein kinase activity / CaMK IV-mediated phosphorylation of CREB / Negative regulation of NMDA receptor-mediated neuronal transmission / Unblocking of NMDA receptors, glutamate binding and activation / Phase 0 - rapid depolarisation / regulation of calcium ion transport / Ion transport by P-type ATPases / Long-term potentiation / Regulation of MECP2 expression and activity / HSF1-dependent transactivation / Ion homeostasis / sarcoplasmic reticulum membrane / Ras activation upon Ca2+ influx through NMDA receptor / RAF activation / regulation of long-term neuronal synaptic plasticity / positive regulation of neuron projection development / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / endocytic vesicle membrane / Interferon gamma signaling / Signaling by BRAF and RAF1 fusions / nervous system development / actin binding / RAF/MAP kinase cascade / peptidyl-serine phosphorylation / protein autophosphorylation / cell differentiation / calmodulin binding / neuron projection / protein phosphorylation / protein serine kinase activity / centrosome / synapse / signal transduction / protein homodimerization activity / nucleoplasm / ATP binding / identical protein binding / cytoplasm / cytosol 類似検索 - 分子機能
Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / NTF2-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. ...Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / NTF2-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性
Calcium/calmodulin-dependent protein kinase type II subunit beta 類似検索 - 構成要素
#195 - 2016年3月 RAFタンパク質キナーゼ (RAF Protein Kinases) 類似性 (1)
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集合体
登録構造単位
G: Calcium/calmodulin-dependent protein kinase type II subunit beta A: Calcium/calmodulin-dependent protein kinase type II subunit beta B: Calcium/calmodulin-dependent protein kinase type II subunit beta C: Calcium/calmodulin-dependent protein kinase type II subunit beta D: Calcium/calmodulin-dependent protein kinase type II subunit beta E: Calcium/calmodulin-dependent protein kinase type II subunit beta F: Calcium/calmodulin-dependent protein kinase type II subunit beta
G: Calcium/calmodulin-dependent protein kinase type II subunit beta A: Calcium/calmodulin-dependent protein kinase type II subunit beta B: Calcium/calmodulin-dependent protein kinase type II subunit beta C: Calcium/calmodulin-dependent protein kinase type II subunit beta D: Calcium/calmodulin-dependent protein kinase type II subunit beta E: Calcium/calmodulin-dependent protein kinase type II subunit beta F: Calcium/calmodulin-dependent protein kinase type II subunit beta
G: Calcium/calmodulin-dependent protein kinase type II subunit beta A: Calcium/calmodulin-dependent protein kinase type II subunit beta B: Calcium/calmodulin-dependent protein kinase type II subunit beta C: Calcium/calmodulin-dependent protein kinase type II subunit beta D: Calcium/calmodulin-dependent protein kinase type II subunit beta E: Calcium/calmodulin-dependent protein kinase type II subunit beta F: Calcium/calmodulin-dependent protein kinase type II subunit beta
解像度: 3.11→37.8 Å / Cor.coef. Fo:Fc: 0.896 / Cor.coef. Fo:Fc free: 0.865 / SU B: 29.173 / SU ML: 0.481 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R Free: 0.592 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY
Rfactor
反射数
%反射
Selection details
Rfree
0.3002
972
5.2 %
RANDOM
Rwork
0.2548
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obs
0.257
17703
97.68 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK