登録情報 | データベース: PDB / ID: 7u2p |
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タイトル | Structure of TcdA GTD in complex with RhoA |
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要素 | - Glucosyltransferase TcdA
- Transforming protein RhoA
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キーワード | TOXIN / GTD |
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機能・相同性 | 機能・相同性情報
RHO GTPases Activate ROCKs / SLIT2:ROBO1 increases RHOA activity / Sema4D mediated inhibition of cell attachment and migration / Sema4D induced cell migration and growth-cone collapse / RHO GTPases Activate Rhotekin and Rhophilins / RHO GTPases activate PKNs / Axonal growth stimulation / PCP/CE pathway / RHO GTPases activate KTN1 / Axonal growth inhibition (RHOA activation) ...RHO GTPases Activate ROCKs / SLIT2:ROBO1 increases RHOA activity / Sema4D mediated inhibition of cell attachment and migration / Sema4D induced cell migration and growth-cone collapse / RHO GTPases Activate Rhotekin and Rhophilins / RHO GTPases activate PKNs / Axonal growth stimulation / PCP/CE pathway / RHO GTPases activate KTN1 / Axonal growth inhibition (RHOA activation) / PI3K/AKT activation / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / EPHA-mediated growth cone collapse / ERBB2 Regulates Cell Motility / RHOC GTPase cycle / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / G beta:gamma signalling through PI3Kgamma / negative regulation of synapse assembly / GPVI-mediated activation cascade / EPHB-mediated forward signaling / RHO GTPases activate CIT / RHOA GTPase cycle / Ovarian tumor domain proteases / G alpha (12/13) signalling events / regulation of dendrite development / RHO GTPases Activate Formins / aortic valve formation / alpha-beta T cell lineage commitment / mitotic cleavage furrow formation / bone trabecula morphogenesis / regulation of modification of synaptic structure / endothelial tube lumen extension / skeletal muscle satellite cell migration / positive regulation of vascular associated smooth muscle contraction / angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure / negative regulation of vascular associated smooth muscle cell migration / Roundabout signaling pathway / negative regulation of intracellular steroid hormone receptor signaling pathway / regulation of neural precursor cell proliferation / cleavage furrow formation / regulation of modification of postsynaptic actin cytoskeleton / positive regulation of smooth muscle contraction / regulation of osteoblast proliferation / forebrain radial glial cell differentiation / cell junction assembly / apical junction assembly / regulation of systemic arterial blood pressure by endothelin / negative regulation of cell migration involved in sprouting angiogenesis / cellular response to chemokine / beta selection / establishment of epithelial cell apical/basal polarity / negative regulation of cell size / regulation of modification of postsynaptic structure / VEGFA-VEGFR2 Pathway / negative regulation of oxidative phosphorylation / negative regulation of motor neuron apoptotic process / stress-activated protein kinase signaling cascade / apolipoprotein A-I-mediated signaling pathway / GTP metabolic process / positive regulation of podosome assembly / negative regulation of cell-substrate adhesion / positive regulation of alpha-beta T cell differentiation / ossification involved in bone maturation / odontogenesis / motor neuron apoptotic process / positive regulation of leukocyte adhesion to vascular endothelial cell / wound healing, spreading of cells / microtubule depolymerization / apical junction complex / host cell cytosol / 転移酵素; グリコシル基を移すもの; 六炭糖残基を移すもの / negative chemotaxis / Rho GDP-dissociation inhibitor binding / myosin binding / positive regulation of actin filament polymerization / stress fiber assembly / glycosyltransferase activity / regulation of neuron projection development / positive regulation of cytokinesis / androgen receptor signaling pathway / cerebral cortex cell migration / cellular response to cytokine stimulus / negative regulation of vascular associated smooth muscle cell proliferation / regulation of calcium ion transport / cleavage furrow / semaphorin-plexin signaling pathway / Rho protein signal transduction / negative regulation of neuron differentiation / mitotic spindle assembly / endothelial cell migration / positive regulation of T cell migration / regulation of microtubule cytoskeleton organization / negative regulation of reactive oxygen species biosynthetic process / cytoplasmic microtubule organization / negative regulation of canonical NF-kappaB signal transduction / cysteine-type peptidase activity / skeletal muscle tissue development / positive regulation of stress fiber assembly / cytoskeleton organization / positive regulation of neuron differentiation類似検索 - 分子機能 TcdA/TcdB toxin, N-terminal helical domain / TcdB toxin N-terminal helical domain / TcdA/TcdB toxin, catalytic glycosyltransferase domain / TcdA/TcdB catalytic glycosyltransferase domain / TcdA/TcdB toxin, pore forming domain / TcdA/TcdB pore forming domain / CGT/MARTX, cysteine protease (CPD) domain / CGT/MARTX, cysteine protease (CPD) domain superfamily / Peptidase C80 family / CGT/MARTX cysteine protease (CPD) domain profile. ...TcdA/TcdB toxin, N-terminal helical domain / TcdB toxin N-terminal helical domain / TcdA/TcdB toxin, catalytic glycosyltransferase domain / TcdA/TcdB catalytic glycosyltransferase domain / TcdA/TcdB toxin, pore forming domain / TcdA/TcdB pore forming domain / CGT/MARTX, cysteine protease (CPD) domain / CGT/MARTX, cysteine protease (CPD) domain superfamily / Peptidase C80 family / CGT/MARTX cysteine protease (CPD) domain profile. / Choline-binding repeat / Putative cell wall binding repeat / Cell wall/choline-binding repeat / Cell wall-binding repeat profile. / Small GTPase Rho / small GTPase Rho family profile. / Nucleotide-diphospho-sugar transferases / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / Small GTP-binding protein domain / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 GUANOSINE-5'-DIPHOSPHATE / : / URIDINE-5'-DIPHOSPHATE-GLUCOSE / Toxin A / Transforming protein RhoA類似検索 - 構成要素 |
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生物種 | Clostridioides difficile (バクテリア)
Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.596 Å |
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データ登録者 | Baohua, C. / Zheng, L. / Kay, P. / Rongsheng, J. |
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資金援助 | 米国, 5件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01AI125704 | 米国 | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01AI139087 | 米国 | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01AI158503 | 米国 | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R21AI156092 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | P30 GM124165 | 米国 |
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引用 | ジャーナル: Sci Rep / 年: 2022 タイトル: Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition. 著者: Chen, B. / Liu, Z. / Perry, K. / Jin, R. |
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履歴 | 登録 | 2022年2月24日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年5月4日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年5月11日 | Group: Structure summary / カテゴリ: struct / Item: _struct.title |
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改定 1.2 | 2022年6月8日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name |
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改定 1.3 | 2023年10月18日 | Group: Data collection / Derived calculations / Refinement description カテゴリ: atom_type / chem_comp_atom ...atom_type / chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model Item: _atom_type.pdbx_N_electrons / _atom_type.pdbx_scat_Z |
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