登録情報 | データベース: PDB / ID: 7ta8 |
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タイトル | NMR structure of crosslinked cyclophilin A |
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要素 | Peptidyl-prolyl cis-trans isomerase A |
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キーワード | ISOMERASE / side chain crosslink |
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機能・相同性 | 機能・相同性情報
negative regulation of protein K48-linked ubiquitination / negative regulation of viral life cycle / regulation of apoptotic signaling pathway / cell adhesion molecule production / lipid droplet organization / heparan sulfate binding / regulation of viral genome replication / leukocyte chemotaxis / endothelial cell activation / virion binding ...negative regulation of protein K48-linked ubiquitination / negative regulation of viral life cycle / regulation of apoptotic signaling pathway / cell adhesion molecule production / lipid droplet organization / heparan sulfate binding / regulation of viral genome replication / leukocyte chemotaxis / endothelial cell activation / virion binding / Basigin interactions / negative regulation of stress-activated MAPK cascade / cyclosporin A binding / Minus-strand DNA synthesis / Plus-strand DNA synthesis / Uncoating of the HIV Virion / Early Phase of HIV Life Cycle / Integration of provirus / APOBEC3G mediated resistance to HIV-1 infection / Calcineurin activates NFAT / viral release from host cell / Binding and entry of HIV virion / positive regulation of viral genome replication / protein peptidyl-prolyl isomerization / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / positive regulation of protein dephosphorylation / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / activation of protein kinase B activity / neutrophil chemotaxis / negative regulation of protein phosphorylation / peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / positive regulation of protein secretion / Assembly Of The HIV Virion / negative regulation of protein kinase activity / Budding and maturation of HIV virion / neuron differentiation / platelet activation / platelet aggregation / SARS-CoV-1 activates/modulates innate immune responses / unfolded protein binding / integrin binding / protein folding / Platelet degranulation / positive regulation of NF-kappaB transcription factor activity / cellular response to oxidative stress / secretory granule lumen / vesicle / ficolin-1-rich granule lumen / positive regulation of MAPK cascade / response to hypoxia / positive regulation of protein phosphorylation / focal adhesion / apoptotic process / Neutrophil degranulation / protein-containing complex / RNA binding / extracellular space / extracellular exosome / extracellular region / membrane / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Cyclophilin-type peptidyl-prolyl cis-trans isomerase / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site / Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain profile. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain / Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD / Cyclophilin-like domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Lu, M. / Toptygin, D. / Xiang, Y. / Shi, Y. / Schwieters, C.D. / Lipinski, E.C. / Ahn, J. / Byeon, I.-J.L. / Gronenborn, A.M. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | P50AI150481 | 米国 | National Science Foundation (NSF, United States) | CHE-1708773 | 米国 |
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引用 | ジャーナル: J.Am.Chem.Soc. / 年: 2022 タイトル: The Magic of Linking Rings: Discovery of a Unique Photoinduced Fluorescent Protein Crosslink. 著者: Lu, M. / Toptygin, D. / Xiang, Y. / Shi, Y. / Schwieters, C.D. / Lipinski, E.C. / Ahn, J. / Byeon, I.L. / Gronenborn, A.M. |
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履歴 | 登録 | 2021年12月20日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年6月1日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年6月29日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.2 | 2023年4月12日 | Group: Advisory / Derived calculations / カテゴリ: pdbx_validate_close_contact / struct_conn |
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改定 1.3 | 2023年6月14日 | Group: Other / カテゴリ: pdbx_database_status / Item: _pdbx_database_status.status_code_nmr_data |
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