登録情報 | データベース: PDB / ID: 7t9u |
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タイトル | Crystal structure of hSTING with an agonist (SHR169224) |
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要素 | Stimulator of interferon genes protein |
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キーワード | IMMUNE SYSTEM/INHIBITOR / IMMUNE SYSTEM / IMMUNE SYSTEM-INHIBITOR COMPLEX / IMMUNE SYSTEM-AGONIST COMPLEX |
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機能・相同性 | 機能・相同性情報
STING complex / STAT6-mediated induction of chemokines / serine/threonine protein kinase complex / protein localization to endoplasmic reticulum / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway ...STING complex / STAT6-mediated induction of chemokines / serine/threonine protein kinase complex / protein localization to endoplasmic reticulum / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway / cGAS/STING signaling pathway / reticulophagy / pattern recognition receptor signaling pathway / cytoplasmic pattern recognition receptor signaling pathway / cellular response to exogenous dsRNA / autophagosome membrane / antiviral innate immune response / positive regulation of macroautophagy / cellular response to organic cyclic compound / autophagosome assembly / autophagosome / positive regulation of type I interferon production / cellular response to interferon-beta / signaling adaptor activity / positive regulation of defense response to virus by host / Regulation of innate immune responses to cytosolic DNA / activation of innate immune response / positive regulation of interferon-beta production / endoplasmic reticulum-Golgi intermediate compartment membrane / secretory granule membrane / cytoplasmic vesicle membrane / positive regulation of DNA-binding transcription factor activity / peroxisome / SARS-CoV-1 activates/modulates innate immune responses / positive regulation of protein binding / protein complex oligomerization / regulation of inflammatory response / defense response to virus / RNA polymerase II-specific DNA-binding transcription factor binding / mitochondrial outer membrane / endosome / Golgi membrane / innate immune response / ubiquitin protein ligase binding / Neutrophil degranulation / endoplasmic reticulum membrane / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / perinuclear region of cytoplasm / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / plasma membrane / cytosol類似検索 - 分子機能 : / Stimulator of interferon genes protein / Stimulator of interferon genes protein, C-terminal domain superfamily / Transmembrane protein 173類似検索 - ドメイン・相同性 Chem-GD2 / Stimulator of interferon genes protein類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.46 Å |
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データ登録者 | Chowdhury, R. / Miller, M. |
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資金援助 | 1件 |
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引用 | ジャーナル: Sci Rep / 年: 2022 タイトル: SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis. 著者: Song, C. / Liu, D. / Liu, S. / Li, D. / Horecny, I. / Zhang, X. / Li, P. / Chen, L. / Miller, M. / Chowdhury, R. / Issa, M. / Shen, R. / Yan, Y. / Zhang, F. / Zhang, L. / Zhang, L. / Bai, C. ...著者: Song, C. / Liu, D. / Liu, S. / Li, D. / Horecny, I. / Zhang, X. / Li, P. / Chen, L. / Miller, M. / Chowdhury, R. / Issa, M. / Shen, R. / Yan, Y. / Zhang, F. / Zhang, L. / Zhang, L. / Bai, C. / Feng, J. / Zhuang, L. / Zhang, R. / Li, J. / Wilkinson, H. / Liu, J. / Tao, W. |
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履歴 | 登録 | 2021年12月20日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年12月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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