登録情報 データベース : PDB / ID : 7shp 構造の表示 ダウンロードとリンクタイトル Crystal structure of hSTING in complex with c[2',3'-(ribo-2'-G, xylo-3'-A)-MP](RJ244) 要素Stimulator of interferon genes protein 詳細 キーワード IMMUNE SYSTEM / STING / agonist / cGAMP analogs機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway ... STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway / cGAS/STING signaling pathway / reticulophagy / pattern recognition receptor signaling pathway / cytoplasmic pattern recognition receptor signaling pathway / cellular response to exogenous dsRNA / autophagosome membrane / antiviral innate immune response / positive regulation of macroautophagy / cellular response to organic cyclic compound / autophagosome assembly / autophagosome / positive regulation of type I interferon production / cellular response to interferon-beta / signaling adaptor activity / positive regulation of defense response to virus by host / activation of innate immune response / Regulation of innate immune responses to cytosolic DNA / positive regulation of interferon-beta production / endoplasmic reticulum-Golgi intermediate compartment membrane / secretory granule membrane / cytoplasmic vesicle membrane / positive regulation of DNA-binding transcription factor activity / peroxisome / SARS-CoV-1 activates/modulates innate immune responses / positive regulation of protein binding / protein complex oligomerization / regulation of inflammatory response / defense response to virus / RNA polymerase II-specific DNA-binding transcription factor binding / mitochondrial outer membrane / endosome / Golgi membrane / innate immune response / ubiquitin protein ligase binding / Neutrophil degranulation / endoplasmic reticulum membrane / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / perinuclear region of cytoplasm / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / plasma membrane / cytosol 類似検索 - 分子機能 : / Stimulator of interferon genes protein / Stimulator of interferon genes protein, C-terminal domain superfamily / Transmembrane protein 173 類似検索 - ドメイン・相同性 Chem-9UR / Stimulator of interferon genes protein 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.2 Å 詳細データ登録者 Xie, W. / Lama, L. / Yang, X.J. / Kuryavyi, V. / Nudelman, I. / Glickman, J.F. / Jones, R.A. / Tuschl, T. / Patel, D.J. 資金援助 米国, 1件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Cancer Institute (NIH/NCI) AI141507 米国
引用ジャーナル : Cell Chem Biol / 年 : 2023タイトル : Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists.著者 : Xie, W. / Lama, L. / Yang, X. / Kuryavyi, V. / Bhattacharya, S. / Nudelman, I. / Yang, G. / Ouerfelli, O. / Glickman, J.F. / Jones, R.A. / Tuschl, T. / Patel, D.J. 履歴 登録 2021年10月11日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2022年10月19日 Provider : repository / タイプ : Initial release改定 1.1 2023年8月16日 Group : Data collection / Database referencesカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / citation_author Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.2 2023年10月18日 Group : Refinement description / カテゴリ : pdbx_initial_refinement_model
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