登録情報 データベース : PDB / ID : 7sei 構造の表示 ダウンロードとリンクタイトル Glucose-6-phosphate 1-dehydrogenase (K403Q) 要素Glucose-6-phosphate 1-dehydrogenase 詳細 キーワード OXIDOREDUCTASE / Glucose-6-phosphate 1-dehydrogenase / K403Q機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of protein glutathionylation / pentose biosynthetic process / ribose phosphate biosynthetic process / glucose-6-phosphate dehydrogenase (NADP+) / positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / glucose-6-phosphate dehydrogenase activity / response to iron(III) ion / Pentose phosphate pathway / pentose-phosphate shunt, oxidative branch / NADPH regeneration ... negative regulation of protein glutathionylation / pentose biosynthetic process / ribose phosphate biosynthetic process / glucose-6-phosphate dehydrogenase (NADP+) / positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / glucose-6-phosphate dehydrogenase activity / response to iron(III) ion / Pentose phosphate pathway / pentose-phosphate shunt, oxidative branch / NADPH regeneration / negative regulation of cell growth involved in cardiac muscle cell development / glucose 6-phosphate metabolic process / NADP metabolic process / pentose-phosphate shunt / D-glucose binding / NFE2L2 regulates pentose phosphate pathway genes / response to food / erythrocyte maturation / cholesterol biosynthetic process / centriolar satellite / negative regulation of reactive oxygen species metabolic process / regulation of neuron apoptotic process / substantia nigra development / glutathione metabolic process / TP53 Regulates Metabolic Genes / response to organic cyclic compound / lipid metabolic process / cytoplasmic side of plasma membrane / glucose metabolic process / NADP binding / cellular response to oxidative stress / response to ethanol / intracellular membrane-bounded organelle / protein homodimerization activity / extracellular exosome / identical protein binding / membrane / cytoplasm / cytosol 類似検索 - 分子機能 Glucose-6-phosphate dehydrogenase, active site / Glucose-6-phosphate dehydrogenase active site. / Glucose-6-phosphate dehydrogenase / Glucose-6-phosphate dehydrogenase, NAD-binding / Glucose-6-phosphate dehydrogenase, C-terminal / Glucose-6-phosphate dehydrogenase, NAD binding domain / Glucose-6-phosphate dehydrogenase, C-terminal domain / NAD(P)-binding domain superfamily 類似検索 - ドメイン・相同性 NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / Glucose-6-phosphate 1-dehydrogenase 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.65 Å 詳細データ登録者 Mathews, I.I. / Garcia, A.A. / Wakatsuki, S. / Mochly-Rosen, D. 資金援助 米国, 5件 詳細 詳細を隠す組織 認可番号 国 Department of Energy (DOE, United States) DE-AC02-76SF00515 米国 National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) HD084422 米国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) P30GM133894 米国 National Science Foundation (NSF, United States) 1656518 米国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) 5T32GM113854 米国
引用ジャーナル : J.Biol.Chem. / 年 : 2022タイトル : Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants.著者 : Garcia, A.A. / Mathews, I.I. / Horikoshi, N. / Matsui, T. / Kaur, M. / Wakatsuki, S. / Mochly-Rosen, D. 履歴 登録 2021年9月30日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2022年8月17日 Provider : repository / タイプ : Initial release改定 1.1 2023年10月18日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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