登録情報 | データベース: PDB / ID: 7sd4 |
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タイトル | SARS-CoV-2 Nucleocapsid N-terminal domain (N-NTD) protein |
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要素 | Nucleoprotein |
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キーワード | STRUCTURAL PROTEIN / COVID-19 / SARS-CoV-2 / nucleocapsid protein / N-terminal domain / RNA-binding domain |
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機能・相同性 | 機能・相同性情報
cytoplasmic capsid assembly / response to host immune response / viral RNA genome packaging / negative regulation of interferon-beta production / Maturation of nucleoprotein / intracellular membraneless organelle / positive regulation of NLRP3 inflammasome complex assembly / MHC class I protein binding / CD28 dependent PI3K/Akt signaling / SARS-CoV-2 targets host intracellular signalling and regulatory pathways ...cytoplasmic capsid assembly / response to host immune response / viral RNA genome packaging / negative regulation of interferon-beta production / Maturation of nucleoprotein / intracellular membraneless organelle / positive regulation of NLRP3 inflammasome complex assembly / MHC class I protein binding / CD28 dependent PI3K/Akt signaling / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / protein sequestering activity / VEGFR2 mediated vascular permeability / molecular condensate scaffold activity / TAK1-dependent IKK and NF-kappa-B activation / DDX58/IFIH1-mediated induction of interferon-alpha/beta / NOD1/2 Signaling Pathway / MHC class I protein complex / Interleukin-1 signaling / RNA stem-loop binding / viral capsid / Interferon alpha/beta signaling / PIP3 activates AKT signaling / Transcription of SARS-CoV-2 sgRNAs / host cell endoplasmic reticulum-Golgi intermediate compartment / viral nucleocapsid / host cell Golgi apparatus / Translation of Structural Proteins / Virion Assembly and Release / host extracellular space / Induction of Cell-Cell Fusion / Attachment and Entry / host cell perinuclear region of cytoplasm / ribonucleoprotein complex / SARS-CoV-2 activates/modulates innate and adaptive immune responses / protein homodimerization activity / RNA binding / extracellular region / identical protein binding / cytoplasm類似検索 - 分子機能 Nucleocapsid protein, betacoronavirus / Nucleocapsid protein, coronavirus / Nucleocapsid protein, C-terminal / Nucleocapsid protein, N-terminal / Nucleocapsid (N) protein, C-terminal domain, coronavirus / Nucleocapsid (N) protein, N-terminal domain, coronavirus / Coronavirus nucleocapsid / Coronavirus nucleocapsid (CoV N) protein N-terminal (NTD) domain profile. / Coronavirus nucleocapsid (CoV N) protein C-terminal (CTD) domain profile.類似検索 - ドメイン・相同性 |
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生物種 | Severe acute respiratory syndrome coronavirus 2 (ウイルス) |
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手法 | 個体NMR / simulated annealing |
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データ登録者 | Sarkar, S. / Runge, B. / Russell, R.W. / Calero, D. / Zeinalilathori, S. / Quinn, C.M. / Lu, M. / Calero, G. / Gronenborn, A.M. / Polenova, T. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | 5P50AI150481 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | 5 P30 GM110758-02 | 米国 |
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引用 | ジャーナル: J.Am.Chem.Soc. / 年: 2022 タイトル: Atomic-Resolution Structure of SARS-CoV-2 Nucleocapsid Protein N-Terminal Domain. 著者: Sarkar, S. / Runge, B. / Russell, R.W. / Movellan, K.T. / Calero, D. / Zeinalilathori, S. / Quinn, C.M. / Lu, M. / Calero, G. / Gronenborn, A.M. / Polenova, T. |
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履歴 | 登録 | 2021年9月29日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年6月8日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年6月15日 | Group: Database references / カテゴリ: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2022年6月29日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2023年6月14日 | Group: Advisory / Other / カテゴリ: pdbx_database_remark / pdbx_database_status Item: _pdbx_database_remark.text / _pdbx_database_status.status_code_nmr_data |
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改定 1.4 | 2024年5月15日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
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Remark 650 | HELIX DETERMINATION METHOD: AUTHOR |
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