登録情報 | データベース: PDB / ID: 7s7g |
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タイトル | Crystal Structure Analysis of Human VLCAD |
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要素 | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial |
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キーワード | OXIDOREDUCTASE / dehydrogenase / mitochondrial acyl-CoA dehydrogenases / Flavin adenine dinucleotide / deficiency / fatty acid oxidation |
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機能・相同性 | 機能・相同性情報
energy derivation by oxidation of organic compounds / very-long-chain acyl-CoA dehydrogenase / very-long-chain fatty acyl-CoA dehydrogenase activity / Beta oxidation of palmitoyl-CoA to myristoyl-CoA / negative regulation of fatty acid oxidation / long-chain fatty acyl-CoA dehydrogenase activity / fatty acid beta-oxidation using acyl-CoA dehydrogenase / acyl-CoA dehydrogenase activity / fatty-acyl-CoA binding / negative regulation of fatty acid biosynthetic process ...energy derivation by oxidation of organic compounds / very-long-chain acyl-CoA dehydrogenase / very-long-chain fatty acyl-CoA dehydrogenase activity / Beta oxidation of palmitoyl-CoA to myristoyl-CoA / negative regulation of fatty acid oxidation / long-chain fatty acyl-CoA dehydrogenase activity / fatty acid beta-oxidation using acyl-CoA dehydrogenase / acyl-CoA dehydrogenase activity / fatty-acyl-CoA binding / negative regulation of fatty acid biosynthetic process / XBP1(S) activates chaperone genes / regulation of cholesterol metabolic process / temperature homeostasis / mitochondrial nucleoid / epithelial cell differentiation / response to cold / mitochondrial membrane / flavin adenine dinucleotide binding / mitochondrial inner membrane / mitochondrial matrix / nucleolus / mitochondrion / nucleoplasm / identical protein binding類似検索 - 分子機能 : / ACAD9/ACADV, C-terminal domain / Acyl-CoA dehydrogenases signature 1. / Acyl-CoA dehydrogenases signature 2. / Acyl-CoA dehydrogenase, conserved site / Acyl-CoA oxidase/dehydrogenase, middle domain superfamily / Acyl-CoA dehydrogenase/oxidase C-terminal / Acyl-CoA dehydrogenase/oxidase, N-terminal / Acyl-CoA dehydrogenase, C-terminal domain / Acyl-CoA dehydrogenase, N-terminal domain ...: / ACAD9/ACADV, C-terminal domain / Acyl-CoA dehydrogenases signature 1. / Acyl-CoA dehydrogenases signature 2. / Acyl-CoA dehydrogenase, conserved site / Acyl-CoA oxidase/dehydrogenase, middle domain superfamily / Acyl-CoA dehydrogenase/oxidase C-terminal / Acyl-CoA dehydrogenase/oxidase, N-terminal / Acyl-CoA dehydrogenase, C-terminal domain / Acyl-CoA dehydrogenase, N-terminal domain / Acyl-CoA oxidase/dehydrogenase, middle domain / Acyl-CoA dehydrogenase, middle domain / Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily / Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily / Acyl-CoA dehydrogenase-like, C-terminal類似検索 - ドメイン・相同性 FLAVIN-ADENINE DINUCLEOTIDE / Very long-chain specific acyl-CoA dehydrogenase, mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.34 Å |
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データ登録者 | Seo, H.-S. / Dhe-Paganon, S. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | | 米国 |
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引用 | ジャーナル: Nat Commun / 年: 2022 タイトル: Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. 著者: Prew, M.S. / Camara, C.M. / Botzanowski, T. / Moroco, J.A. / Bloch, N.B. / Levy, H.R. / Seo, H.S. / Dhe-Paganon, S. / Bird, G.H. / Herce, H.D. / Gygi, M.A. / Escudero, S. / Wales, T.E. / ...著者: Prew, M.S. / Camara, C.M. / Botzanowski, T. / Moroco, J.A. / Bloch, N.B. / Levy, H.R. / Seo, H.S. / Dhe-Paganon, S. / Bird, G.H. / Herce, H.D. / Gygi, M.A. / Escudero, S. / Wales, T.E. / Engen, J.R. / Walensky, L.D. |
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履歴 | 登録 | 2021年9月15日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年9月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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改定 1.2 | 2024年5月29日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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