Entry | Database: PDB / ID: 7s1l |
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Title | Crystal structure of E.coli DsbA in complex with compound MIPS-0001896 (compound 72) |
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Components | Thiol:disulfide interchange protein DsbA |
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Keywords | OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor / thioredoxin fold / thiol-disulfide oxidoreductase / inhibitor / DsbA / OXIDOREDUCTASE / OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex |
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Function / homology | Function and homology information
cellular response to antibiotic / protein disulfide isomerase activity / protein-disulfide reductase activity / outer membrane-bounded periplasmic spaceSimilarity search - Function Thiol:disulphide interchange protein DsbA/DsbL / DSBA-like thioredoxin domain / DSBA-like thioredoxin domain / Thioredoxin, conserved site / Thioredoxin family active site. / Thioredoxin domain profile. / Thioredoxin domain / Thioredoxin-like superfamilySimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Escherichia coli (E. coli) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 1.623 Å |
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Authors | Heras, B. / Scanlon, M.J. / Martin, J.L. / Caria, S. |
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Funding support | Australia, 1items Organization | Grant number | Country |
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National Health and Medical Research Council (NHMRC, Australia) | GNT455860 | Australia |
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Citation | Journal: Chemrxiv / Year: 2022 Title: Fluoromethylketone-fragment conjugates designed as covalent modifiers of EcDsbA are atypical substrates Authors: Bradley, C.D. / Whitehouse, R.L. / Rimmer, K. / Williams, M. / Heras, B. / Caria, S. / Ilyichova, O. / Vazirani, M. / Mohanty, B. / Harper, J. / Scanlon, M.J. / Simpson, J.S. |
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History | Deposition | Sep 2, 2021 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Feb 8, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Apr 3, 2024 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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