登録情報 | データベース: PDB / ID: 7rjr |
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タイトル | Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with BCLTF1 |
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要素 | - Bcl-2-associated transcription factor 1
- Bromodomain-containing protein 4
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キーワード | SIGNALING PROTEIN / BRD4 / BCLTF1 / acetyllysine |
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機能・相同性 | 機能・相同性情報
: / : / positive regulation of DNA-templated transcription initiation / mediator complex / RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of intrinsic apoptotic signaling pathway ...: / : / positive regulation of DNA-templated transcription initiation / mediator complex / RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of intrinsic apoptotic signaling pathway / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / cellular response to leukemia inhibitory factor / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / nuclear speck / chromatin remodeling / positive regulation of apoptotic process / negative regulation of DNA-templated transcription / DNA damage response / chromatin binding / apoptotic process / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 Bcl-2-associated transcription factor 1 / THRAP3/BCLAF1 family / THRAP3/BCLAF1 family / Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I ...Bcl-2-associated transcription factor 1 / THRAP3/BCLAF1 family / THRAP3/BCLAF1 family / Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily類似検索 - ドメイン・相同性 Bromodomain-containing protein 4 / Bcl-2-associated transcription factor 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.45 Å |
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データ登録者 | Fedorov, E. / Islam, K. / Ghosh, A. |
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資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM123234 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM130752 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | P01GM118303 | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Uncovering the Bromodomain Interactome using Site-Specific Azide-Acetyllysine Photochemistry, Proteomic Profiling and Structural Characterization 著者: Wagner, S. / Fedorov, E. / Sudhamalla, B. / Jnawali, H.N. / Debiec, R. / Ghosh, A. / Islam, K. |
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履歴 | 登録 | 2021年7月21日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年8月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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改定 1.2 | 2023年11月15日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond / Item: _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 |
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