Entry | Database: PDB / ID: 7rik |
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Title | Magic-Angle-Spinning NMR Structure of Kinesin-1 Motor Domain Assembled with Microtubules |
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Components | Kinesin-1 heavy chain |
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Keywords | MOTOR PROTEIN / kinesin-1 motor domain / Kif5b / microtubules / MTs / integrated structural biology |
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Function / homology | Function and homology information
cytoplasm organization / cytolytic granule membrane / plus-end-directed vesicle transport along microtubule / mitocytosis / anterograde dendritic transport of neurotransmitter receptor complex / anterograde neuronal dense core vesicle transport / anterograde axonal protein transport / retrograde neuronal dense core vesicle transport / vesicle transport along microtubule / lysosome localization ...cytoplasm organization / cytolytic granule membrane / plus-end-directed vesicle transport along microtubule / mitocytosis / anterograde dendritic transport of neurotransmitter receptor complex / anterograde neuronal dense core vesicle transport / anterograde axonal protein transport / retrograde neuronal dense core vesicle transport / vesicle transport along microtubule / lysosome localization / positive regulation of potassium ion transport / Kinesins / plus-end-directed microtubule motor activity / RHO GTPases activate KTN1 / stress granule disassembly / mitochondrion transport along microtubule / COPI-dependent Golgi-to-ER retrograde traffic / centrosome localization / microtubule motor activity / ciliary rootlet / natural killer cell mediated cytotoxicity / kinesin complex / synaptic vesicle transport / Insulin processing / microtubule-based movement / centriolar satellite / axon cytoplasm / phagocytic vesicle / MHC class II antigen presentation / dendrite cytoplasm / regulation of membrane potential / axon guidance / positive regulation of synaptic transmission, GABAergic / positive regulation of protein localization to plasma membrane / cellular response to type II interferon / Signaling by ALK fusions and activated point mutants / microtubule binding / vesicle / microtubule / cadherin binding / protein-containing complex binding / perinuclear region of cytoplasm / ATP hydrolysis activity / mitochondrion / ATP binding / identical protein binding / membrane / cytosolSimilarity search - Function Kinesin-like protein / Kinesin motor domain signature. / Kinesin motor domain, conserved site / Kinesin motor domain / Kinesin motor domain profile. / Kinesin motor, catalytic domain. ATPase. / Kinesin motor domain / Kinesin motor domain superfamily / P-loop containing nucleoside triphosphate hydrolaseSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | SOLID-STATE NMR / simulated annealing |
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Authors | Zhang, C. / Guo, C. / Russell, R.W. / Quinn, C.M. / Li, M. / Williams, J.C. / Gronenborn, A.M. / Polenova, T. |
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Funding support | United States, 2items Organization | Grant number | Country |
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National Science Foundation (NSF, United States) | CHE0959496 | United States | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | P30 GM110758 | United States |
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Citation | Journal: Nat Commun / Year: 2022 Title: Magic-angle-spinning NMR structure of the kinesin-1 motor domain assembled with microtubules reveals the elusive neck linker orientation Authors: Zhang, C. / Guo, C. / Russell, R.W. / Quinn, C.M. / Li, M. / Williams, J.C. / Gronenborn, A.M. / Polenova, T. |
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History | Deposition | Jul 20, 2021 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Nov 23, 2022 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 15, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
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