PDB-7rao: Structure of M66I mutant of disulfide stabilized HIV-1 CA hexamer

ID or keywords:

Entry

Database: PDB / ID: 7rao

Title

Structure of M66I mutant of disulfide stabilized HIV-1 CA hexamer

Components

Capsid protein p24

Keywords

VIRAL PROTEIN

Function / homology

Function and homology information

viral budding via host ESCRT complex / ISG15 antiviral mechanism / host multivesicular body / viral nucleocapsid / host cell nucleus / host cell plasma membrane / structural molecule activity / virion membrane / RNA binding / zinc ion binding / membrane
Similarity search - Function

Biological species

Human immunodeficiency virus 1

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 2.29 Å

Authors

Bester, S.M. / Kvaratskhelia, M.

Funding support

United States, 3items

Organization	Grant number	Country
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)	R01-AI157802	United States
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)	T32-AI150547	United States
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)	U54-AI150472	United States

Citation

Journal: To Be Published
Title: Structural and mechanistic bases of viral resistance to long-acting HIV-1 capsid inhibitor, Lenacapavir
Authors: Bester, S.M. / Annamalai, A.S. / Adu-Ampratwum, D. / Haney, R. / Fuchs, J.R. / Kvaratskhelia, M.

History

Deposition	Jul 2, 2021	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Nov 2, 2022	Provider: repository / Type: Initial release
Revision 1.1	Oct 18, 2023	Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	7rao.cif.gz	325.8 KB	Display	PDBx/mmCIF format
PDB format	pdb7rao.ent.gz	219.1 KB	Display	PDB format
PDBx/mmJSON format	7rao.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Summary document	7rao_validation.pdf.gz	450.3 KB	Display	wwPDB validaton report
Full document	7rao_full_validation.pdf.gz	454.2 KB	Display
Data in XML	7rao_validation.xml.gz	27.8 KB	Display
Data in CIF	7rao_validation.cif.gz	39.6 KB	Display
Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/ra/7rao ftp://data.pdbj.org/pub/pdb/validation_reports/ra/7rao	HTTPS FTP

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Related structure data

Related structure data	3h47S S: Starting model for refinement
Similar structure data	Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#163 - Jul 2013 HIV Capsid similarity (3) #87 - Mar 2007 Zinc Fingers similarity (2)

Deposited unit

A: Capsid protein p24

B: Capsid protein p24

C: Capsid protein p24

hetero molecules

78 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Capsid protein p24

B: Capsid protein p24

hetero molecules

A: Capsid protein p24

B: Capsid protein p24

hetero molecules

A: Capsid protein p24

B: Capsid protein p24

hetero molecules

defined by author
156 kDa, 6 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

C: Capsid protein p24

hetero molecules

x 6

defined by author
157 kDa, 6 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1
crystal symmetry operation	2_555	-y,x-y,z	1
crystal symmetry operation	3_555	-x+y,-x,z	1
crystal symmetry operation	4_555	-x,-y,z	1
crystal symmetry operation	5_555	y,-x+y,z	1
crystal symmetry operation	6_555	x-y,x,z	1

Unit cell

Length a, b, c (Å)	158.962, 158.962, 57.711
Angle α, β, γ (deg.)	90.000, 90.000, 120.000
Int Tables number	168
Space group name H-M	P6
Space group name Hall	P6
Symmetry operation	#1: x,y,z #2: x-y,x,z #3: y,-x+y,z #4: -y,x-y,z #5: -x+y,-x,z #6: -x,-y,z

Noncrystallographic symmetry (NCS)

NCS domain:

ID	Ens-ID	Details
d_1	ens_1	(chain "A" and (resid 1 through 6 or resid 8...
d_2	ens_1	(chain "B" and (resid 1 through 6 or resid 8...
d_3	ens_1	(chain "C" and (resid 1 through 6 or resid 8...

NCS domain segments:

Dom-ID	Component-ID	Ens-ID	Beg label comp-ID	End label comp-ID	Label asym-ID	Label seq-ID
d_1	1	ens_1	PRO	LEU	A	1 - 6
d_1	2	ens_1	GLY	LYS	A	8 - 131
d_1	3	ens_1	TRP	ILE	A	134 - 154
d_1	4	ens_1	GLN	PHE	A	156 - 162
d_1	5	ens_1	ASP	ALA	A	164 - 175
d_1	6	ens_1	GLN	GLN	A	177
d_1	7	ens_1	LEU	VAL	A	190 - 192
d_1	8	ens_1	ASN	LEU	A	194 - 212
d_1	9	ens_1	GLU	GLN	A	214 - 220
d_2	1	ens_1	PRO	LEU	B	1 - 6
d_2	2	ens_1	GLY	LYS	B	8 - 131
d_2	3	ens_1	TRP	ILE	B	133 - 153
d_2	4	ens_1	GLN	PHE	B	155 - 161
d_2	5	ens_1	ASP	ALA	B	163 - 174
d_2	6	ens_1	GLN	GLN	B	176
d_2	7	ens_1	LEU	VAL	B	180 - 182
d_2	8	ens_1	ASN	LEU	B	184 - 202
d_2	9	ens_1	GLU	GLN	B	204 - 210
d_3	1	ens_1	PRO	LEU	C	1 - 6
d_3	2	ens_1	GLY	LYS	C	8 - 131
d_3	3	ens_1	TRP	ILE	C	133 - 153
d_3	4	ens_1	GLN	PHE	C	155 - 161
d_3	5	ens_1	ASP	ALA	C	163 - 174
d_3	6	ens_1	GLN	GLN	C	176
d_3	7	ens_1	LEU	VAL	C	182 - 184
d_3	8	ens_1	ASN	LEU	C	186 - 204
d_3	9	ens_1	GLU	GLN	C	206 - 212

NCS oper:

ID	Code	Matrix	Vector
1	given	(-0.999955155955, -0.00517892896368, -0.0079287309317), (0.00521354474177, -0.999976941694, -0.00435144025911), (-0.0079060123086, -0.00439258191638, 0.99995909926)	158.603308917, -92.2681140491, 0.447680593907
2	given	(0.0247637030091, -0.999689957498, 0.00259767043647), (-0.999685580285, -0.0247736605519, -0.00387379838332), (0.0039369511468, -0.00250092408499, -0.999989122838)	-47.7416631291, 78.3481427387, 26.638633275

#1: Protein	Capsid protein p24 / CA Mass: 25443.234 Da / Num. of mol.: 3 / Mutation: A14C, E45C, M66I, W184A, M185A Source method: isolated from a genetically manipulated source Source: (gene. exp.) Human immunodeficiency virus 1 / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: P12493
#2: Chemical	ChemComp-IOD / IODIDE ION Mass: 126.904 Da / Num. of mol.: 10 / Source method: obtained synthetically / Formula: I
#3: Chemical	ChemComp-CL / CHLORIDE ION Mass: 35.453 Da / Num. of mol.: 12 / Source method: obtained synthetically / Formula: Cl
#4: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 377 / Source method: isolated from a natural source / Formula: H₂O
Has ligand of interest	N

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.76 Å³/Da / Density % sol: 55.4 %
Crystal grow	Temperature: 277.15 K / Method: vapor diffusion, hanging drop Details: 0.125-0.35M Sodium Iodide, 2-8% Peg 3350, 6% glycerol, 0.1M sodium cacodylate pH 6.5

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Data collection

Diffraction	Mean temperature: 100 K / Serial crystal experiment: N
Diffraction source	Source: SYNCHROTRON / Site: ALS / Beamline: 4.2.2 / Wavelength: 1.00003 Å
Detector	Type: RDI CMOS_8M / Detector: CMOS / Date: Jul 1, 2020
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 1.00003 Å / Relative weight: 1
Reflection	Resolution: 2.29→44.23 Å / Num. obs: 37715 / % possible obs: 99.7 % / Redundancy: 2 % / B_iso Wilson estimate: 31.22 Å² / CC_1/2: 0.998 / R_merge(I) obs: 0.039 / Net I/σ(I): 20.2
Reflection shell	Resolution: 2.29→2.37 Å / Redundancy: 2 % / R_merge(I) obs: 0.229 / Mean I/σ(I) obs: 2 / Num. unique obs: 3732 / CC_1/2: 0.921 / % possible all: 99.3

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Processing

Software

Name	Version	Classification
PHENIX	1.18.2_3874	refinement
XDS		data reduction
XDS		data scaling
PHASER		phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT
Starting model: 3h47

3h47

Resolution: 2.29→44.22 Å / SU ML: 0.2752 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 26.5375
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2

	R_factor	Num. reflection	% reflection
R_free	0.2436	1898	5.04 %
R_work	0.2155	35781	-
obs	0.2169	37679	99.61 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL

Displacement parameters

B_iso mean: 38.81 Å²

Refinement step

Cycle: LAST / Resolution: 2.29→44.22 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	4980	0	22	377	5379

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.0017	5101
X-RAY DIFFRACTION	f_angle_d	0.4686	6936
X-RAY DIFFRACTION	f_chiral_restr	0.0389	784
X-RAY DIFFRACTION	f_plane_restr	0.0041	905
X-RAY DIFFRACTION	f_dihedral_angle_d	15.7499	1931

Refine LS restraints NCS

Ens-ID	Dom-ID	Auth asym-ID	Refine-ID	Type	Rms dev position (Å)
ens_1	d_2	A	X-RAY DIFFRACTION	Torsion NCS	0.636929385386
ens_1	d_3	A	X-RAY DIFFRACTION	Torsion NCS	0.611229363572

LS refinement shell

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Refine-ID	% reflection obs (%)
2.29-2.35	0.3115	116	0.2763	2545	X-RAY DIFFRACTION	98.96
2.35-2.41	0.2942	147	0.2327	2554	X-RAY DIFFRACTION	100
2.41-2.48	0.271	127	0.2351	2530	X-RAY DIFFRACTION	99.85
2.48-2.56	0.2786	142	0.2386	2518	X-RAY DIFFRACTION	99.96
2.56-2.65	0.2665	151	0.2339	2538	X-RAY DIFFRACTION	100
2.65-2.76	0.2712	146	0.2205	2550	X-RAY DIFFRACTION	99.81
2.76-2.88	0.2509	162	0.2332	2505	X-RAY DIFFRACTION	99.96
2.89-3.04	0.2678	133	0.2198	2553	X-RAY DIFFRACTION	99.96
3.04-3.23	0.2564	122	0.2158	2577	X-RAY DIFFRACTION	100
3.23-3.48	0.2209	135	0.2093	2554	X-RAY DIFFRACTION	100
3.48-3.83	0.2475	126	0.2123	2534	X-RAY DIFFRACTION	97.79
3.83-4.38	0.2277	105	0.1769	2597	X-RAY DIFFRACTION	99.37
4.38-5.52	0.2109	150	0.1929	2576	X-RAY DIFFRACTION	99.93
5.52-44.22	0.2164	136	0.235	2650	X-RAY DIFFRACTION	99.08

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	3.35989043797	-0.959019390242	2.77613153675	1.74036601769	-1.53959353171	7.84173617617	0.0596909677696	0.0333569670097	-0.367772631583	-0.0765072727964	0.0832209051633	-0.13615563174	0.546031637113	0.956932897027	-0.0764380616337	0.227830611465	0.0247033346398	0.0320187476397	0.326946245528	0.00492795635723	0.297463988978	27.8598004825	-22.9832105652	28.5301128762
2	1.1564692266	1.32960016598	-1.64170705842	1.78565521957	-2.74959992676	4.66501324365	-0.22891547979	-0.771953905698	0.0882474124349	0.474388644605	0.12133048572	0.385033776524	0.422870756876	0.442998409304	0.000500840738104	0.511712589324	0.154860909513	0.041488681999	0.548692542546	0.053102446443	0.283161083674	23.3375250789	-25.854224351	47.2865900871
3	2.14365041602	-0.138517533319	-0.878589967101	2.10808210476	-1.92908745161	4.617194422	-0.0686048479334	-0.388270578983	-0.12944616387	0.241857059063	-0.0449099550139	-0.0409830159898	-0.253546736767	0.273562361018	0.099395946886	0.187250485245	-0.0110170776919	-0.0100701537248	0.203047463003	-0.0260470001051	0.216735633773	22.1032569976	-16.525527472	34.8825018826
4	3.07839268759	2.25782831458	-1.37613637348	5.76131617085	-3.52447245167	5.46958056297	-0.273974457381	0.2540980099	-0.390957707177	-0.926740010486	0.0869683308257	0.385094453705	0.780733361844	-0.242141987989	0.171095522034	0.306744252597	-0.0446353661931	0.0181113726339	0.319415464441	-0.0258619168439	0.300408549162	34.1657133914	2.28479450038	8.49565734274
5	0.862469245725	-1.39939491229	1.32483861543	3.96074460904	-4.71539326326	7.4928042499	-0.347784951833	-0.166643308626	-0.210098068258	1.20425328559	-0.0605958387349	-0.709326370047	0.489996887198	1.53653305566	0.329971871323	0.610552067365	0.067402072447	-0.079822107135	0.514266521211	-0.107500343663	0.326845383206	42.5522988348	2.82765260662	14.662122953
6	2.89743424062	1.13370908135	-2.53456135338	4.79094169284	3.59978680366	8.04766325511	-0.306093520782	0.0986640693187	-0.179110597116	-0.500359045766	0.315379872048	0.168015660805	-0.438841100878	0.818246862627	0.0502814042927	0.287826450284	-0.0839196229461	0.0117396593373	0.365015177012	-0.0101269203981	0.367300203385	41.4771456511	14.455655051	10.1432793708
7	1.24826953918	0.152259169055	-0.129714278823	2.59873126941	-0.296708255384	1.26877130692	-0.0307636143386	0.0341258119906	-0.0405635821555	-0.14247420994	-0.0302092018441	0.0950155388395	0.0466003636633	-0.083790956127	0.0465575072932	0.181456041936	-0.0240349489687	-0.00241857550661	0.188685839748	0.00787172348297	0.2165187807	93.559209413	-62.7484632516	-1.53495765048
8	2.57765893555	-0.384388090362	-0.719720280225	2.3619350295	-1.3296351001	4.63365007752	0.164695356844	0.420335597087	-0.0226054126306	-0.608518207107	-0.121492635339	-0.0759796479803	0.335724665974	0.163990046102	0.0232845891956	0.335563804018	-0.00745724172503	0.0379066176508	0.278759606291	-0.0162224800708	0.295246059806	99.3460693229	-67.8945540267	-11.477151746
9	4.59547925415	-0.0300707227203	0.182174228441	4.00235067488	-0.250132483809	4.16793758211	-0.00923480237055	-0.195040159722	-0.238954913643	0.145041868827	0.0148637879087	0.122661764312	0.319007307772	0.0613621738902	0.0315324606505	0.267743777688	0.00929670663612	-0.013537719726	0.156842614221	0.0102524379294	0.271725886852	76.3955410873	-83.8927846286	16.4661817509
10	6.79542067719	2.75024888173	0.968523188149	5.83098747733	-4.46426320245	9.07493023791	0.0360774410002	-0.171086021613	-0.0827720755621	-1.49281333342	0.847023037146	0.312387660764	0.403444776672	-0.320271149753	-0.64796782031	0.320339180575	-0.0369155636414	0.0559748377885	0.340527315726	0.0434270000944	0.455183815303	64.6818282091	-85.2159249449	12.4823386823
11	1.58610145005	0.305937156787	1.25550989958	3.01122750312	0.407437401256	2.32457484281	-0.0462259708476	0.0943162736183	-0.142796476234	-0.263727108559	0.0521494745296	-0.23402926779	-0.145098580811	0.0897655548616	-0.0456919836039	0.206670753327	0.0132682674982	0.0278164317658	0.33274615662	0.0297723229464	0.31202743969	71.393838899	-33.4220227194	-2.11532109383
12	0.636893841146	-0.110015271683	0.105914348124	1.32064897842	-0.0471248614356	2.25812657985	-0.0253552514337	-0.0389691891472	0.0332691072541	-0.149900906996	0.00956667762024	0.211746614594	-0.11702740485	-0.078689625015	0.0192752617923	0.197909842426	-0.0275948621548	-0.0118923731102	0.255179695601	-0.0306697346345	0.255170363475	59.0105910534	-24.3871505284	-1.20788143884
13	0.742040324462	1.23447746608	2.12115379815	2.15613407635	3.6691559954	6.11806933284	0.308039891854	0.492418937806	0.0365334693781	-0.724642602417	-0.50819025458	0.231469861969	-0.390332698485	-0.20904814206	0.260275608924	0.536231178531	0.117505114295	-0.0916322103499	0.575544641455	-4.87779160267E-5	0.341717586781	53.0390414719	-23.2119318275	-20.1635248013
14	3.36373974101	0.216203181336	0.709499129341	4.49227199312	0.315882084935	2.90371622352	0.0827557896853	0.350469071811	-0.0345767516649	-0.338299075921	-0.0169537709601	0.466436332757	0.000676070144938	0.50012641954	-0.0204657716259	0.366749249677	0.0139465393837	-0.05184531294	0.338423823671	-0.0690568111703	0.297727691644	60.1531706183	-29.0471852188	-16.5850229339
15	2.02630919764	0.662957573115	2.52797058038	2.22438933757	2.40258046116	9.5332849337	-0.0560105867945	0.0381887362323	0.305188492854	-0.239884038892	-0.179770171683	-0.0703835740821	-0.701329822136	-0.194337366197	0.283681787889	0.217967554801	-0.00363741006105	-0.0155783409798	0.179712213302	0.0104130387371	0.303565881335	64.5213944253	-19.84220386	0.48928543676
16	5.44717188956	-0.156448920313	0.925365696954	3.5290204849	0.338648733596	2.51510083268	-0.236955217838	-0.604585411855	0.211573477803	0.355647564976	-0.0717110126097	0.110169911916	0.02921142091	-0.133466878033	0.250232580204	0.266758233104	-0.0148854822177	0.00664220098902	0.388392016446	-0.0354376704622	0.258412124844	79.7191013501	-10.2012285694	22.6355296799
17	5.94544190007	2.05081233487	2.74734489808	2.06923253597	0.619834793282	4.40831632497	0.232331889749	-0.116749759793	-0.582276191218	-0.184225657588	-0.0382332371838	0.0423356831429	0.0904690860598	0.137242942156	-0.168617640156	0.267410014405	0.0163254055477	-0.029134042174	0.214061091343	0.0247650063366	0.282806252024	81.8649290066	-13.4766813889	15.6329251115
18	6.96779915389	3.07208958849	2.52903162017	5.68943972836	1.4265982528	2.66154441761	-0.573346854007	0.239741679879	0.796349483186	-0.811022483907	0.00720192552847	-0.209701310876	-1.02406524797	-0.303970943306	0.432230938773	0.387347274658	0.074379156236	-0.014814098177	0.320834184459	-0.0592525988069	0.397567436936	82.8741019211	-4.2160463813	15.9311077768
19	5.00024428812	-0.215825205835	-1.76493651902	6.03874886794	4.46462981906	3.81648548247	-0.0255782034569	-0.135763987085	0.01312756238	-0.341271626544	0.363472949636	-0.689710119533	-0.568591825182	0.44624104876	-0.403109340763	0.371629458814	-0.0632261825094	-0.0337113347266	0.38310677091	-0.0117634157626	0.584160305867	93.9385671451	-4.39861874232	16.7654327543
20	5.90420386843	-0.62805968658	1.61542312132	5.98907777974	-2.31675306111	1.83908945967	-0.100727648704	-0.713737571239	0.512929710376	0.307742178434	-0.286404551708	0.368806467722	-0.558100302612	-0.143577379467	0.38732246	0.365784563121	0.0206577646834	0.0103657598166	0.433903034039	-0.0944953884197	0.370604656693	8.51527303675	-7.8230883511	42.6598805849
21	1.47309088256	-0.481620068219	-0.39479708295	1.39848751647	-0.502124212783	0.694222367233	0.0835603346311	0.102033182441	0.0233877113083	0.0093055997995	0.00600736931182	0.0712117606257	-0.0434457022396	0.0978461648952	-0.0808884893473	0.201789124774	-0.00247531327517	-0.0139834637545	0.171245675873	-0.0135739877834	0.211377262608	14.9509420092	-10.8752998405	23.9796772178

Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

ID	Refine TLS-ID	Selection details	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
1	1	chain 'C' and (resid 63 through 83 )	C	C	63 - 83	63 - 83
2	2	chain 'C' and (resid 84 through 104 )	C	C	84 - 104	84 - 104
3	3	chain 'C' and (resid 105 through 145 )	C	C	105 - 145	105 - 145
4	4	chain 'C' and (resid 146 through 175 )	C	C	146 - 175	146 - 175
5	5	chain 'C' and (resid 176 through 192 )	C	C	176 - 192	176 - 185
6	6	chain 'C' and (resid 193 through 220 )	C	C	193 - 220	186 - 213
7	7	chain 'A' and (resid 1 through 83 )	A	A	1 - 83	1 - 83
8	8	chain 'A' and (resid 84 through 145 )	A	A	84 - 145	84 - 146
9	9	chain 'A' and (resid 146 through 205 )	A	A	146 - 205	147 - 206
10	10	chain 'A' and (resid 206 through 219 )	A	A	206 - 219	207 - 220
11	11	chain 'B' and (resid 1 through 43 )	B	B	1 - 43	1 - 43
12	12	chain 'B' and (resid 44 through 83 )	B	B	44 - 83	44 - 83
13	13	chain 'B' and (resid 84 through 104 )	B	B	84 - 104	84 - 104
14	14	chain 'B' and (resid 105 through 125 )	B	B	105 - 125	105 - 125
15	15	chain 'B' and (resid 126 through 145 )	B	B	126 - 145	126 - 145
16	16	chain 'B' and (resid 146 through 160 )	B	B	146 - 160	146 - 160
17	17	chain 'B' and (resid 161 through 175 )	B	B	161 - 175	161 - 175
18	18	chain 'B' and (resid 176 through 195 )	B	B	176 - 195	176 - 186
19	19	chain 'B' and (resid 196 through 220 )	B	B	196 - 220	187 - 211
20	20	chain 'C' and (resid 1 through 16 )	C	C	1 - 16	1 - 16
21	21	chain 'C' and (resid 17 through 62 )	C	C	17 - 62	17 - 62

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