Entry Database : PDB / ID : 7qei Structure visualization Downloads & linksTitle Structure of human MTHFD2L in complex with TH7299 ComponentsProbable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 Details Keywords OXIDOREDUCTASE / inhibitor / isoform / mthfd2L / 1C-metabolismFunction / homology Function and homology informationFunction Domain/homology Component
10-formyltetrahydrofolate metabolic process / methylenetetrahydrofolate dehydrogenase (NAD+) / methylenetetrahydrofolate dehydrogenase (NAD+) activity / methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / methenyltetrahydrofolate cyclohydrolase activity / methylenetetrahydrofolate dehydrogenase (NADP+) activity / Metabolism of folate and pterines / methionine biosynthetic process / L-histidine biosynthetic process ... 10-formyltetrahydrofolate metabolic process / methylenetetrahydrofolate dehydrogenase (NAD+) / methylenetetrahydrofolate dehydrogenase (NAD+) activity / methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / methenyltetrahydrofolate cyclohydrolase activity / methylenetetrahydrofolate dehydrogenase (NADP+) activity / Metabolism of folate and pterines / methionine biosynthetic process / L-histidine biosynthetic process / purine nucleotide biosynthetic process / tetrahydrofolate interconversion / folic acid metabolic process / mitochondrial inner membrane / mitochondrial matrix / mitochondrion Similarity search - Function Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. / Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site / Tetrahydrofolate dehydrogenase/cyclohydrolase / Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain / Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain / Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain / Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain / Aminoacid dehydrogenase-like, N-terminal domain superfamily / NAD(P)-binding domain superfamily Similarity search - Domain/homology Chem-9L9 / 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE / Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.1 Å DetailsAuthors Gustafsson, R. / Scaletti, E.R. / Stenmark, P. Funding support Sweden, 2items Details Hide detailsOrganization Grant number Country Cancerfonden Sweden Swedish Research Council Sweden
CitationJournal : Chemmedchem / Year : 2022Title : The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors.Authors : Scaletti, E.R. / Gustafsson Westergren, R. / Andersson, Y. / Wiita, E. / Henriksson, M. / Homan, E.J. / Jemth, A.S. / Helleday, T. / Stenmark, P. History Deposition Dec 3, 2021 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 12, 2022 Provider : repository / Type : Initial releaseRevision 1.1 Jan 31, 2024 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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