登録情報 | データベース: PDB / ID: 7qcy |
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タイトル | Two-state liquid NMR Structure of a PDZ2 Domain from hPTP1E, complexed with RA-GEF2 peptide |
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要素 | Tyrosine-protein phosphatase non-receptor type 13 |
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キーワード | HYDROLASE / Protein-protein recognition domain |
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機能・相同性 | 機能・相同性情報
negative regulation of excitatory synapse assembly / cellular response to toxic substance / phosphatidylinositol 3-kinase regulatory subunit binding / Interleukin-37 signaling / RND1 GTPase cycle / RND2 GTPase cycle / RND3 GTPase cycle / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / Synthesis of PIPs at the plasma membrane / peptidyl-tyrosine dephosphorylation ...negative regulation of excitatory synapse assembly / cellular response to toxic substance / phosphatidylinositol 3-kinase regulatory subunit binding / Interleukin-37 signaling / RND1 GTPase cycle / RND2 GTPase cycle / RND3 GTPase cycle / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / Synthesis of PIPs at the plasma membrane / peptidyl-tyrosine dephosphorylation / protein dephosphorylation / protein-tyrosine-phosphatase / negative regulation of protein phosphorylation / protein tyrosine phosphatase activity / fibrillar center / lamellipodium / cell body / cytoskeleton / extracellular exosome / nucleoplasm / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Tyrosine-protein phosphatase non-receptor type 13 / Unstructured linker region on PTN13 protein between PDZ / KIND domain / KIND domain profile. / kinase non-catalytic C-lobe domain / FERM, C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM, N-terminal / FERM N-terminal domain ...Tyrosine-protein phosphatase non-receptor type 13 / Unstructured linker region on PTN13 protein between PDZ / KIND domain / KIND domain profile. / kinase non-catalytic C-lobe domain / FERM, C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM, N-terminal / FERM N-terminal domain / FERM central domain / FERM/acyl-CoA-binding protein superfamily / FERM central domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Protein tyrosine phosphatase, catalytic domain / PTP type protein phosphatase domain profile. / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / PH-like domain superfamily / Ubiquitin-like domain superfamily類似検索 - ドメイン・相同性 Tyrosine-protein phosphatase non-receptor type 13類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Ashkinadze, D. / Kadavath, H. / Chi, C. / Friedmann, M. / Strotz, D. / Kumari, P. / Minges, M. / Cadalbert, R. / Koenigl, S. / Guentert, P. ...Ashkinadze, D. / Kadavath, H. / Chi, C. / Friedmann, M. / Strotz, D. / Kumari, P. / Minges, M. / Cadalbert, R. / Koenigl, S. / Guentert, P. / Voegeli, B. / Riek, R. |
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資金援助 | スイス, 1件 組織 | 認可番号 | 国 |
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Swiss National Science Foundation | | スイス |
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引用 | ジャーナル: Nat Commun / 年: 2022 タイトル: Atomic resolution protein allostery from the multi-state structure of a PDZ domain. 著者: Ashkinadze, D. / Kadavath, H. / Pokharna, A. / Chi, C.N. / Friedmann, M. / Strotz, D. / Kumari, P. / Minges, M. / Cadalbert, R. / Konigl, S. / Guntert, P. / Vogeli, B. / Riek, R. |
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履歴 | 登録 | 2021年11月25日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2022年9月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年11月2日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2024年6月19日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
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