Crystal structure of RARalpha/RXRalpha ligand binding domain heterodimer in complex with BMS614 and oleic acid
要素
Isoform Alpha-1-deltaBC of Retinoic acid receptor alpha
Retinoic acid receptor RXR-alpha
キーワード
GENE REGULATION / Nuclear receptor
機能・相同性
機能・相同性情報
Transcriptional regulation of granulopoiesis / Carnitine shuttle / Transcriptional regulation of white adipocyte differentiation / Signaling by Retinoic Acid / Sertoli cell fate commitment / positive regulation of binding / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / SUMOylation of intracellular receptors / trachea cartilage development ...Transcriptional regulation of granulopoiesis / Carnitine shuttle / Transcriptional regulation of white adipocyte differentiation / Signaling by Retinoic Acid / Sertoli cell fate commitment / positive regulation of binding / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / SUMOylation of intracellular receptors / trachea cartilage development / Recycling of bile acids and salts / Synthesis of bile acids and bile salts / Nuclear Receptor transcription pathway / visceral serous pericardium development / glandular epithelial cell development / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / ventricular cardiac muscle cell differentiation / mesenchyme development / Endogenous sterols / chondroblast differentiation / positive regulation of translational initiation by iron / embryonic camera-type eye development / MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis / maternal placenta development / protein kinase B binding / negative regulation of granulocyte differentiation / growth plate cartilage development / angiogenesis involved in coronary vascular morphogenesis / prostate gland development / positive regulation of T-helper 2 cell differentiation / Regulation of lipid metabolism by PPARalpha / retinoic acid-responsive element binding / negative regulation of cartilage development / regulation of hematopoietic progenitor cell differentiation / Cytoprotection by HMOX1 / secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development / positive regulation of thyroid hormone receptor signaling pathway / positive regulation of interleukin-13 production / positive regulation of interleukin-5 production / cardiac muscle cell differentiation / retinoic acid binding / camera-type eye development / outflow tract septum morphogenesis / TGFBR3 expression / response to vitamin A / positive regulation of vitamin D receptor signaling pathway / heterocyclic compound binding / limb development / apoptotic cell clearance / regulation of myelination / ureteric bud development / Signaling by Retinoic Acid / RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding / DNA-binding transcription repressor activity / regulation of branching involved in prostate gland morphogenesis / protein kinase A binding / ventricular cardiac muscle tissue morphogenesis / positive regulation of interleukin-4 production / alpha-actinin binding / face development / germ cell development / negative regulation of type II interferon production / nuclear steroid receptor activity / negative regulation of tumor necrosis factor production / cellular response to estrogen stimulus / cardiac muscle cell proliferation / response to retinoic acid / positive regulation of bone mineralization / heart morphogenesis / retinoic acid receptor signaling pathway / hormone-mediated signaling pathway / positive regulation of cell cycle / cellular response to retinoic acid / response to cytokine / positive regulation of neuron differentiation / embryo implantation / negative regulation of miRNA transcription / mRNA regulatory element binding translation repressor activity / placenta development / hippocampus development / RNA polymerase II transcription regulatory region sequence-specific DNA binding / neural tube closure / SUMOylation of intracellular receptors / chromatin DNA binding / mRNA transcription by RNA polymerase II / liver development / female pregnancy / regulation of synaptic plasticity / mRNA 5'-UTR binding / Nuclear Receptor transcription pathway / RNA polymerase II transcription regulator complex / Activation of anterior HOX genes in hindbrain development during early embryogenesis / histone deacetylase binding / transcription coactivator binding / multicellular organism growth / Transcriptional regulation of granulopoiesis / nuclear receptor activity / sequence-specific double-stranded DNA binding / response to estradiol 類似検索 - 分子機能