- PDB-7q46: Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2... -
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基本情報
登録情報
データベース: PDB / ID: 7q46
タイトル
Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of pericentriolar material 1 protein
要素
E3 ubiquitin-protein ligase HERC2
Pericentriolar material 1 protein
キーワード
PROTEIN BINDING / 7-bladed beta-propeller HERC2 RCC1-like Domain 2 RLD2 ubiquitin ligase PCM1 pericentriolar material 1 protein DXDKDED motif
機能・相同性
機能・相同性情報
protein-containing complex localization to centriolar satellite / intraciliary transport involved in cilium assembly / interkinetic nuclear migration / microtubule anchoring / microtubule anchoring at centrosome / ciliary transition zone / regulation of protein complex stability / neuronal stem cell population maintenance / SUMO binding / positive regulation of intracellular protein transport ...protein-containing complex localization to centriolar satellite / intraciliary transport involved in cilium assembly / interkinetic nuclear migration / microtubule anchoring / microtubule anchoring at centrosome / ciliary transition zone / regulation of protein complex stability / neuronal stem cell population maintenance / SUMO binding / positive regulation of intracellular protein transport / HECT-type E3 ubiquitin transferase / non-motile cilium assembly / centrosome cycle / protein localization to centrosome / pericentriolar material / social behavior / centriolar satellite / cilium assembly / SUMOylation of DNA damage response and repair proteins / cytoplasmic microtubule organization / Loss of Nlp from mitotic centrosomes / Loss of proteins required for interphase microtubule organization from the centrosome / Recruitment of mitotic centrosome proteins and complexes / Recruitment of NuMA to mitotic centrosomes / Anchoring of the basal body to the plasma membrane / centriole / AURKA Activation by TPX2 / guanyl-nucleotide exchange factor activity / ciliary basal body / Nonhomologous End-Joining (NHEJ) / intracellular protein transport / neuron migration / G2/M DNA damage checkpoint / negative regulation of neurogenesis / Regulation of PLK1 Activity at G2/M Transition / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / apical part of cell / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / Processing of DNA double-strand break ends / spermatogenesis / nuclear membrane / proteasome-mediated ubiquitin-dependent protein catabolic process / molecular adaptor activity / protein ubiquitination / DNA repair / centrosome / ubiquitin protein ligase binding / DNA damage response / protein-containing complex / zinc ion binding / nucleoplasm / identical protein binding / membrane / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能
Pericentriolar material 1 protein / Pericentriolar material 1 protein, C-terminal / Pericentriolar material 1 C terminus / HERC2, APC10 domain / HERC2, zinc finger, ZZ-type / : / Beta-propeller repeat TECPR / Mib-herc2 / Mib/herc2 domain superfamily / Mib_herc2 ...Pericentriolar material 1 protein / Pericentriolar material 1 protein, C-terminal / Pericentriolar material 1 C terminus / HERC2, APC10 domain / HERC2, zinc finger, ZZ-type / : / Beta-propeller repeat TECPR / Mib-herc2 / Mib/herc2 domain superfamily / Mib_herc2 / MIB/HERC2 domain profile. / Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins. / CPH domain / Mouse development and cellular proliferation protein Cullin-7 / Regulator of chromosome condensation (RCC1) signature 2. / Regulator of chromosome condensation (RCC1) repeat / Regulator of chromosome condensation, RCC1 / Regulator of chromosome condensation (RCC1) repeat profile. / APC10/DOC domain / Anaphase-promoting complex, subunit 10 (APC10) / DOC domain profile. / Anaphase-promoting complex, subunit 10 (APC10) / Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II / Cytochrome b5 family, heme-binding domain profile. / Cytochrome b5-like heme/steroid binding domain / Cytochrome b5-like heme/steroid binding domain superfamily / Cytochrome b5-like Heme/Steroid binding domain / Cytochrome b5-like Heme/Steroid binding domain / HECT domain / HECT, E3 ligase catalytic domain / HECT-domain (ubiquitin-transferase) / HECT domain profile. / Domain Homologous to E6-AP Carboxyl Terminus with / Zinc finger ZZ-type signature. / Zinc-binding domain, present in Dystrophin, CREB-binding protein. / Zinc finger, ZZ type / Zinc finger, ZZ-type / Zinc finger, ZZ-type superfamily / Zinc finger ZZ-type profile. / Galactose-binding-like domain superfamily / Ribosomal protein L2, domain 2 類似検索 - ドメイン・相同性
CITRIC ACID / E3 ubiquitin-protein ligase HERC2 / Pericentriolar material 1 protein 類似検索 - 構成要素