登録情報 データベース : PDB / ID : 7psc 構造の表示 ダウンロードとリンクタイトル Crystal structure of the disease-causing I358T mutant of the human dihydrolipoamide dehydrogenase 要素Dihydrolipoyl dehydrogenase, mitochondrial 詳細 キーワード OXIDOREDUCTASE / lipoamide dehydrogenase / pathogenic mutation / E3 deficiency / alpha-ketoglutarate dehydrogenase complex / 2-oxoglutarate dehydrogenase complex / pyruvate dehydrogenase complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
acetyltransferase complex / acrosomal matrix / Glycine degradation / : / dihydrolipoyl dehydrogenase / dihydrolipoyl dehydrogenase activity / acetyl-CoA biosynthetic process from pyruvate / Lysine catabolism / oxoglutarate dehydrogenase complex / : ... acetyltransferase complex / acrosomal matrix / Glycine degradation / : / dihydrolipoyl dehydrogenase / dihydrolipoyl dehydrogenase activity / acetyl-CoA biosynthetic process from pyruvate / Lysine catabolism / oxoglutarate dehydrogenase complex / : / branched-chain amino acid catabolic process / Citric acid cycle (TCA cycle) / pyruvate dehydrogenase complex / Branched-chain amino acid catabolism / Pyruvate metabolism / Glyoxylate metabolism and glycine degradation / Regulation of pyruvate dehydrogenase (PDH) complex / motile cilium / sperm capacitation / Signaling by Retinoic Acid / mitochondrial electron transport, NADH to ubiquinone / gastrulation / Mitochondrial protein degradation / regulation of membrane potential / flavin adenine dinucleotide binding / mitochondrial matrix / mitochondrion / proteolysis / nucleus 類似検索 - 分子機能 Dihydrolipoamide dehydrogenase / Pyridine nucleotide-disulphide oxidoreductase, class I / Pyridine nucleotide-disulphide oxidoreductase, class I, active site / Pyridine nucleotide-disulphide oxidoreductases class-I active site. / Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain / Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain / FAD/NAD-linked reductase, dimerisation domain superfamily / FAD/NAD(P)-binding domain / Pyridine nucleotide-disulphide oxidoreductase / FAD/NAD(P)-binding domain superfamily 類似検索 - ドメイン・相同性 FLAVIN-ADENINE DINUCLEOTIDE / Dihydrolipoyl dehydrogenase, mitochondrial 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.436 Å 詳細データ登録者 Nemes-Nikodem, E. / Szabo, E. / Zambo, Z. / Vass, K.R. / Taberman, H. / Torocsik, B. / Weiss, M.S. / Adam-Vizi, V. / Ambrus, A. 資金援助 ハンガリー, European Union, 7件 詳細 詳細を隠す組織 認可番号 国 Hungarian Academy of Sciences 02001 [to A.-V.V.] ハンガリー Hungarian National Research, Development and Innovation Office 112230 [to A.-V.V.] ハンガリー Hungarian Academy of Sciences KTIA_13_NAP_III/6 and 2017-1.2.1-NKP-2017-00002 [to A.-V.V.] ハンガリー European Union (EU) Horizon 2020 Research and Innovation Programme, 16204087-ST [to S.E. and A.A.] European Union Hungarian National Research, Development and Innovation Office FIKP 61826 690289 EATV [to A.A] ハンガリー Hungarian National Research, Development and Innovation Office FIKP 61830Z0100 EATV [to A.A] ハンガリー European Union (EU) Horizon 2020 Research and Innovation Programme MX-201-00149-ST [to A.A.] European Union
引用ジャーナル : Int J Mol Sci / 年 : 2023タイトル : Structural and Biochemical Investigation of Selected Pathogenic Mutants of the Human Dihydrolipoamide Dehydrogenase.著者 : Szabo, E. / Nemes-Nikodem, E. / Vass, K.R. / Zambo, Z. / Zrupko, E. / Torocsik, B. / Ozohanics, O. / Nagy, B. / Ambrus, A. 履歴 登録 2021年9月22日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2023年4月5日 Provider : repository / タイプ : Initial release改定 1.1 2023年7月26日 Group : Author supporting evidence / Database references / Refinement descriptionカテゴリ : citation / citation_author ... citation / citation_author / pdbx_audit_support / struct_ncs_dom_lim Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _pdbx_audit_support.country / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id 改定 1.2 2024年2月7日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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