登録情報 データベース : PDB / ID : 7pos 構造の表示 ダウンロードとリンクタイトル PI3 kinase delta in complex with 5-(3,6-dihydro-2H-pyran-4-yl)-2-methoxy-N-(5-{3-[4-(propan-2-yl)piperazin-1-yl]prop-1-yn-1-yl}pyridin-3-yl)pyridine-3-sulfonamide 要素Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 詳細 キーワード SIGNALING PROTEIN / PI3 KINASE DELTA機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / Interleukin receptor SHC signaling / Synthesis of PIPs at the plasma membrane / PIP3 activates AKT signaling / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / Regulation of signaling by CBL / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Interleukin-3, Interleukin-5 and GM-CSF signaling / RET signaling / phosphatidylinositol 3-kinase complex ... Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / Interleukin receptor SHC signaling / Synthesis of PIPs at the plasma membrane / PIP3 activates AKT signaling / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / Regulation of signaling by CBL / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Interleukin-3, Interleukin-5 and GM-CSF signaling / RET signaling / phosphatidylinositol 3-kinase complex / 1-phosphatidylinositol-4-phosphate 3-kinase activity / 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity / phosphatidylinositol-4,5-bisphosphate 3-kinase / phosphatidylinositol 3-kinase / phosphatidylinositol-3-phosphate biosynthetic process / 1-phosphatidylinositol-3-kinase activity / B cell activation / phosphatidylinositol-mediated signaling / B cell homeostasis / homeostasis of number of cells / defense response to fungus / phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of angiogenesis / chemotaxis / kinase activity / adaptive immune response / cell differentiation / cell surface receptor signaling pathway / inflammatory response / negative regulation of gene expression / innate immune response / positive regulation of gene expression / ATP binding / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 PI3Kdelta, catalytic domain / PI3-kinase family, p85-binding domain / PI3-kinase family, p85-binding domain / Phosphatidylinositol 3-kinase, adaptor-binding domain / Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain profile. / PI3-kinase family, Ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain / PI3-kinase family, ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain profile. / Phosphoinositide 3-kinase C2 ... PI3Kdelta, catalytic domain / PI3-kinase family, p85-binding domain / PI3-kinase family, p85-binding domain / Phosphatidylinositol 3-kinase, adaptor-binding domain / Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain profile. / PI3-kinase family, Ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain / PI3-kinase family, ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain profile. / Phosphoinositide 3-kinase C2 / Phosphoinositide 3-kinase, region postulated to contain C2 domain / C2 phosphatidylinositol 3-kinase-type domain / C2 phosphatidylinositol 3-kinase (PI3K)-type domain profile. / Phosphoinositide 3-kinase, accessory (PIK) domain superfamily / Phosphoinositide 3-kinase family, accessory domain (PIK domain) / Phosphoinositide 3-kinase family, accessory domain (PIK domain) / Phosphoinositide 3-kinase, accessory (PIK) domain / Phosphatidylinositol kinase / PIK helical domain profile. / Phosphatidylinositol 3- and 4-kinases signature 1. / Phosphatidylinositol 3/4-kinase, conserved site / Phosphatidylinositol 3- and 4-kinases signature 2. / Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily / Phosphoinositide 3-kinase, catalytic domain / Phosphatidylinositol 3- and 4-kinase / Phosphatidylinositol 3- and 4-kinases catalytic domain profile. / Phosphatidylinositol 3-/4-kinase, catalytic domain / C2 domain superfamily / Armadillo-type fold / Ubiquitin-like domain superfamily / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性 Chem-7XN / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 類似検索 - 構成要素生物種 Mus musculus (ハツカネズミ)手法 X線回折 / シンクロトロン / フーリエ合成 / 解像度 : 2.493 Å 詳細データ登録者 Rowland, P. / Convery, M. 資金援助 1件 詳細 詳細を隠す 引用ジャーナル : J.Med.Chem. / 年 : 2021タイトル : Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3K delta with a Novel Binding Mode.著者: Down, K. / Amour, A. / Anderson, N.A. / Barton, N. / Campos, S. / Cannons, E.P. / Clissold, C. / Convery, M.A. / Coward, J.J. / Doyle, K. / Duempelfeld, B. / Edwards, C.D. / Goldsmith, M.D. / ... 著者 : Down, K. / Amour, A. / Anderson, N.A. / Barton, N. / Campos, S. / Cannons, E.P. / Clissold, C. / Convery, M.A. / Coward, J.J. / Doyle, K. / Duempelfeld, B. / Edwards, C.D. / Goldsmith, M.D. / Krause, J. / Mallett, D.N. / McGonagle, G.A. / Patel, V.K. / Rowedder, J. / Rowland, P. / Sharpe, A. / Sriskantharajah, S. / Thomas, D.A. / Thomson, D.W. / Uddin, S. / Hamblin, J.N. / Hessel, E.M. 履歴 登録 2021年9月9日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2021年9月29日 Provider : repository / タイプ : Initial release改定 1.1 2021年10月6日 Group : Data collection / Database references / カテゴリ : citation / pdbx_database_procItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.2 2024年6月19日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond
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