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Yorodumi- PDB-7p19: Crystal structure of SARS-CoV-2 RBD Q498Y complexed with human ACE2 -
+Open data
-Basic information
Entry | Database: PDB / ID: 7p19 | |||||||||
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Title | Crystal structure of SARS-CoV-2 RBD Q498Y complexed with human ACE2 | |||||||||
Components |
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Keywords | VIRAL PROTEIN / Viral spike / angiotensin converting enzyme-II / SARS-COV-2 / ACE-2 | |||||||||
Function / homology | Function and homology information positive regulation of amino acid transport / angiotensin-converting enzyme 2 / positive regulation of L-proline import across plasma membrane / Hydrolases; Acting on peptide bonds (peptidases); Metallocarboxypeptidases / angiotensin-mediated drinking behavior / regulation of systemic arterial blood pressure by renin-angiotensin / tryptophan transport / positive regulation of gap junction assembly / regulation of vasoconstriction / regulation of cardiac conduction ...positive regulation of amino acid transport / angiotensin-converting enzyme 2 / positive regulation of L-proline import across plasma membrane / Hydrolases; Acting on peptide bonds (peptidases); Metallocarboxypeptidases / angiotensin-mediated drinking behavior / regulation of systemic arterial blood pressure by renin-angiotensin / tryptophan transport / positive regulation of gap junction assembly / regulation of vasoconstriction / regulation of cardiac conduction / peptidyl-dipeptidase activity / maternal process involved in female pregnancy / angiotensin maturation / Metabolism of Angiotensinogen to Angiotensins / metallocarboxypeptidase activity / carboxypeptidase activity / negative regulation of signaling receptor activity / Attachment and Entry / positive regulation of cardiac muscle contraction / regulation of cytokine production / viral life cycle / blood vessel diameter maintenance / brush border membrane / regulation of transmembrane transporter activity / negative regulation of smooth muscle cell proliferation / negative regulation of ERK1 and ERK2 cascade / cilium / metallopeptidase activity / endocytic vesicle membrane / positive regulation of reactive oxygen species metabolic process / virus receptor activity / regulation of cell population proliferation / regulation of inflammatory response / Maturation of spike protein / endopeptidase activity / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / Potential therapeutics for SARS / structural constituent of virion / entry receptor-mediated virion attachment to host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / receptor-mediated endocytosis of virus by host cell / membrane fusion / Attachment and Entry / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / receptor ligand activity / host cell surface receptor binding / symbiont entry into host cell / membrane raft / apical plasma membrane / endoplasmic reticulum lumen / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / cell surface / extracellular space / zinc ion binding / extracellular exosome / extracellular region / identical protein binding / membrane / plasma membrane Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) Severe acute respiratory syndrome coronavirus 2 | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.24 Å | |||||||||
Authors | Erausquin, E. / Lopez-Sagaseta, J. | |||||||||
Funding support | Spain, 2items
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Citation | Journal: Acta Crystallogr D Struct Biol / Year: 2022 Title: Structural bases for the higher adherence to ACE2 conferred by the SARS-CoV-2 spike Q498Y substitution. Authors: Erausquin, E. / Glaser, F. / Fernandez-Recio, J. / Lopez-Sagaseta, J. #1: Journal: Biorxiv / Year: 2021 Title: A single de novo substitution in SARS-CoV-2 spike informs enhanced adherence to human ACE2 Authors: Erausquin, E. / Lopez-Sagaseta, J. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7p19.cif.gz | 767.5 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7p19.ent.gz | 537.9 KB | Display | PDB format |
PDBx/mmJSON format | 7p19.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7p19_validation.pdf.gz | 491.5 KB | Display | wwPDB validaton report |
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Full document | 7p19_full_validation.pdf.gz | 504.9 KB | Display | |
Data in XML | 7p19_validation.xml.gz | 52.2 KB | Display | |
Data in CIF | 7p19_validation.cif.gz | 69.7 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/p1/7p19 ftp://data.pdbj.org/pub/pdb/validation_reports/p1/7p19 | HTTPS FTP |
-Related structure data
Related structure data | 6m0jS S: Starting model for refinement |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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