登録情報 | データベース: PDB / ID: 7p0k |
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タイトル | Crystal structure of Autotaxin (ENPP2) with 18F-labeled positron emission tomography ligand |
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要素 | Isoform 2 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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キーワード | HYDROLASE / Autotaxin (ATX) / lysophosphatidic acid (LPA) / fluorine-18 / positron emission tomography (PET) / inflammation |
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機能・相同性 | 機能・相同性情報
response to polycyclic arene / alkylglycerophosphoethanolamine phosphodiesterase / sphingolipid catabolic process / phospholipase D / phospholipid catabolic process / phosphatidylcholine catabolic process / phospholipase D activity / positive regulation of lamellipodium morphogenesis / phosphodiesterase I activity / lysophospholipase activity ...response to polycyclic arene / alkylglycerophosphoethanolamine phosphodiesterase / sphingolipid catabolic process / phospholipase D / phospholipid catabolic process / phosphatidylcholine catabolic process / phospholipase D activity / positive regulation of lamellipodium morphogenesis / phosphodiesterase I activity / lysophospholipase activity / scavenger receptor activity / alkylglycerophosphoethanolamine phosphodiesterase activity / polysaccharide binding / negative regulation of cell-matrix adhesion / positive regulation of oligodendrocyte differentiation / positive regulation of epithelial cell migration / positive regulation of focal adhesion assembly / estrous cycle / phospholipid metabolic process / positive regulation of substrate adhesion-dependent cell spreading / cellular response to cadmium ion / regulation of cell migration / cell chemotaxis / cellular response to estradiol stimulus / positive regulation of peptidyl-tyrosine phosphorylation / nucleic acid binding / immune response / calcium ion binding / positive regulation of cell population proliferation / extracellular space / zinc ion binding類似検索 - 分子機能 Somatomedin B domain, chordata / Somatomedin B -like domains / Somatomedin B domain / Somatomedin B-like domain superfamily / Somatomedin B domain / Somatomedin B domain (SMB) signature. / Somatomedin B (SMB) domain profile. / Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase / Type I phosphodiesterase / nucleotide pyrophosphatase / Extracellular Endonuclease, subunit A ...Somatomedin B domain, chordata / Somatomedin B -like domains / Somatomedin B domain / Somatomedin B-like domain superfamily / Somatomedin B domain / Somatomedin B domain (SMB) signature. / Somatomedin B (SMB) domain profile. / Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase / Type I phosphodiesterase / nucleotide pyrophosphatase / Extracellular Endonuclease, subunit A / DNA/RNA non-specific endonuclease / DNA/RNA non-specific endonuclease / DNA/RNA non-specific endonuclease / DNA/RNA non-specific endonuclease / DNA/RNA non-specific endonuclease superfamily / His-Me finger superfamily / Alkaline-phosphatase-like, core domain superfamily類似検索 - ドメイン・相同性 Chem-4I0 / IODIDE ION / THIOCYANATE ION / Autotaxin類似検索 - 構成要素 |
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生物種 | Rattus norvegicus (ドブネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.2 Å |
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データ登録者 | Salgado-Polo, F. / Shao, T. / Xiao, Z. / Van, R. / Chen, J. / Rong, J. / Haider, A. / Shao, Y. / Josephson, L. / Perrakis, A. / Liang, S.H. |
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資金援助 | オランダ, 1件 組織 | 認可番号 | 国 |
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Oncode Institute | | オランダ |
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引用 | ジャーナル: J Med Chem / 年: 2021 タイトル: Imaging Autotaxin In Vivo with 18 F-Labeled Positron Emission Tomography Ligands 著者: Deng, X. / Salgado-Polo, F. / Shao, T. / Xiao, Z. / Van, R. / Chen, J. / Rong, J. / Haider, A. / Shao, Y. / Josephson, L. / Perrakis, A. / Liang, S.H. |
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履歴 | 登録 | 2021年6月29日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2022年7月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月31日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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改定 1.2 | 2024年10月16日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature Item: _pdbx_entry_details.has_protein_modification |
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