登録情報 | データベース: PDB / ID: 7nq9 |
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タイトル | C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 2-benzyl-N-cyclopropyl-6-(1-methyl-1H-1,2,3-triazol-4-yl)isonicotinamide |
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要素 | Bromodomain-containing protein 2 |
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キーワード | NUCLEAR PROTEIN / INHIBITOR / HISTONE / EPIGENETIC READER / BROMODOMAIN / BRD2 / BROMODOMAIN CONTAINING PROTEIN 2 / ANTAGONIST |
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機能・相同性 | 機能・相同性情報
acetylation-dependent protein binding / chromatin looping / positive regulation of T-helper 17 cell lineage commitment / RUNX3 regulates p14-ARF / protein localization to chromatin / lysine-acetylated histone binding / neural tube closure / nucleosome assembly / spermatogenesis / nuclear speck ...acetylation-dependent protein binding / chromatin looping / positive regulation of T-helper 17 cell lineage commitment / RUNX3 regulates p14-ARF / protein localization to chromatin / lysine-acetylated histone binding / neural tube closure / nucleosome assembly / spermatogenesis / nuclear speck / protein serine/threonine kinase activity / chromatin binding / regulation of transcription by RNA polymerase II / chromatin / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 NET domain superfamily / : / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain profile. ...NET domain superfamily / : / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Bromodomain類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / フーリエ合成 / 解像度: 1.602 Å |
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データ登録者 | Chung, C.W. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2021 タイトル: Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors. 著者: Aylott, H.E. / Atkinson, S.J. / Bamborough, P. / Bassil, A. / Chung, C.W. / Gordon, L. / Grandi, P. / Gray, J.R.J. / Harrison, L.A. / Hayhow, T.G. / Messenger, C. / Mitchell, D. / Phillipou, ...著者: Aylott, H.E. / Atkinson, S.J. / Bamborough, P. / Bassil, A. / Chung, C.W. / Gordon, L. / Grandi, P. / Gray, J.R.J. / Harrison, L.A. / Hayhow, T.G. / Messenger, C. / Mitchell, D. / Phillipou, A. / Preston, A. / Prinjha, R.K. / Rianjongdee, F. / Rioja, I. / Seal, J.T. / Wall, I.D. / Watson, R.J. / Woolven, J.M. / Demont, E.H. |
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履歴 | 登録 | 2021年3月1日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2021年3月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年4月7日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.2 | 2024年6月19日 | Group: Data collection / Database references / Derived calculations カテゴリ: atom_type / chem_comp_atom ...atom_type / chem_comp_atom / chem_comp_bond / database_2 Item: _atom_type.pdbx_N_electrons / _atom_type.pdbx_scat_Z ..._atom_type.pdbx_N_electrons / _atom_type.pdbx_scat_Z / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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