登録情報 | データベース: PDB / ID: 7m16 |
---|
タイトル | Triazole-based BET family bromodomain inhibitor bound to BRD4(D1) |
---|
要素 | Bromodomain-containing protein 4 |
---|
キーワード | PROTEIN BINDING / inhibitor |
---|
機能・相同性 | 機能・相同性情報
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ...RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site ...Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.42 Å |
---|
データ登録者 | Johnson, J.A. / Pomerantz, W. |
---|
資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
---|
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R35GM124718 | 米国 | American Cancer Society | 129819-IRG-16-189-58-IRG88 | 米国 |
|
---|
引用 | ジャーナル: ACS Med. Chem. Lett. / 年: 2019 タイトル: Systematically Mitigating the p38alpha Activity of Triazole-based BET Inhibitors 著者: Carlson, A.S. / Cui, H. / Divakaran, A. / Johnson, J.A. / Brunner, R.M. / Pomerantz, W.C.K. / Topczewski, J.J. |
---|
履歴 | 登録 | 2021年3月12日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2021年9月29日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
---|
|
---|