登録情報 | データベース: PDB / ID: 7k3s |
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タイトル | Solution NMR Structure of the Coiled-coil BRCA1-PALB2 Heterodimer |
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要素 | - Breast cancer type 1 susceptibility protein homolog
- Partner and localizer of BRCA2
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キーワード | ONCOPROTEIN / Homologous Recombination / DNA |
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機能・相同性 | 機能・相同性情報
: / : / : / : / : / : / : / mitotic G2 DNA damage checkpoint signaling => GO:0007095 / : / Homologous DNA Pairing and Strand Exchange ...: / : / : / : / : / : / : / mitotic G2 DNA damage checkpoint signaling => GO:0007095 / : / Homologous DNA Pairing and Strand Exchange / : / regulation of cell cycle => GO:0051726 / Resolution of D-loop Structures through Holliday Junction Intermediates / : / SUMOylation of DNA damage response and repair proteins / HDR through Homologous Recombination (HRR) / BRCA1-BARD1 complex / BRCA1-A complex / negative regulation of intracellular estrogen receptor signaling pathway / : / chordate embryonic development / cellular response to indole-3-methanol / negative regulation of fatty acid biosynthetic process / lateral element / dosage compensation by inactivation of X chromosome / protein K6-linked ubiquitination / post-anal tail morphogenesis / mitotic G2/M transition checkpoint / postreplication repair / DNA repair complex / RNA polymerase binding / centrosome cycle / inner cell mass cell proliferation / response to ionizing radiation / mesoderm development / centrosome duplication / positive regulation of vascular endothelial growth factor production / negative regulation of reactive oxygen species metabolic process / embryonic organ development / protein autoubiquitination / somitogenesis / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / condensed chromosome / positive regulation of DNA repair / condensed nuclear chromosome / positive regulation of protein ubiquitination / chromosome segregation / animal organ morphogenesis / double-strand break repair via homologous recombination / RING-type E3 ubiquitin transferase / multicellular organism growth / fatty acid biosynthetic process / positive regulation of protein import into nucleus / response to estrogen / ubiquitin-protein transferase activity / positive regulation of angiogenesis / intrinsic apoptotic signaling pathway in response to DNA damage / double-strand break repair / chromosome / cellular response to tumor necrosis factor / in utero embryonic development / damaged DNA binding / transcription coactivator activity / nuclear body / transcription cis-regulatory region binding / protein ubiquitination / mitochondrial matrix / ribonucleoprotein complex / negative regulation of DNA-templated transcription / centrosome / apoptotic process / ubiquitin protein ligase binding / DNA damage response / chromatin binding / positive regulation of gene expression / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / RNA binding / zinc ion binding / nucleoplasm / identical protein binding / nucleus / plasma membrane / cytoplasm類似検索 - 分子機能 Partner and localiser of BRCA2, WD40 domain / Partner and localizer of BRCA2 / Partner and localizer of BRCA2 WD40 domain / Breast cancer type 1 susceptibility protein (BRCA1) / BRCA1, serine-rich domain / BRCA1-associated / Serine-rich domain associated with BRCT / Zinc finger, C3HC4 RING-type / Zinc finger, C3HC4 type (RING finger) / BRCA1 C Terminus (BRCT) domain ...Partner and localiser of BRCA2, WD40 domain / Partner and localizer of BRCA2 / Partner and localizer of BRCA2 WD40 domain / Breast cancer type 1 susceptibility protein (BRCA1) / BRCA1, serine-rich domain / BRCA1-associated / Serine-rich domain associated with BRCT / Zinc finger, C3HC4 RING-type / Zinc finger, C3HC4 type (RING finger) / BRCA1 C Terminus (BRCT) domain / breast cancer carboxy-terminal domain / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / BRCT domain profile. / BRCT domain / BRCT domain superfamily / Ring finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, RING/FYVE/PHD-type / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily類似検索 - ドメイン・相同性 Breast cancer type 1 susceptibility protein homolog / Partner and localizer of BRCA2類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Daigham, N.S. / Liu, G. / Bunting, S.F. / Montelione, G.T. |
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資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | R01 CA190858 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM120574 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | S10OD018207 | 米国 |
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引用 | |
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履歴 | 登録 | 2020年9月13日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2021年9月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年6月14日 | Group: Other / カテゴリ: pdbx_database_status / Item: _pdbx_database_status.status_code_nmr_data |
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改定 1.2 | 2024年5月15日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
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