登録情報 データベース : PDB / ID : 7ftf 構造の表示 ダウンロードとリンクタイトル Crystal Structure of apo human cyclic GMP-AMP synthase 要素Cyclic GMP-AMP synthase 詳細 キーワード TRANSFERASE / IMMUNE RESPONSE / NTASE / DNA SENSOR機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
cyclic GMP-AMP synthase / 2',3'-cyclic GMP-AMP synthase activity / STING mediated induction of host immune responses / paracrine signaling / poly-ADP-D-ribose modification-dependent protein binding / regulation of immunoglobulin production / cGAS/STING signaling pathway / pattern recognition receptor signaling pathway / regulation of T cell activation / cytoplasmic pattern recognition receptor signaling pathway ... cyclic GMP-AMP synthase / 2',3'-cyclic GMP-AMP synthase activity / STING mediated induction of host immune responses / paracrine signaling / poly-ADP-D-ribose modification-dependent protein binding / regulation of immunoglobulin production / cGAS/STING signaling pathway / pattern recognition receptor signaling pathway / regulation of T cell activation / cytoplasmic pattern recognition receptor signaling pathway / negative regulation of cGAS/STING signaling pathway / cGMP-mediated signaling / cellular response to exogenous dsRNA / positive regulation of type I interferon production / negative regulation of double-strand break repair via homologous recombination / nucleosome binding / positive regulation of defense response to virus by host / phosphatidylinositol-4,5-bisphosphate binding / activation of innate immune response / cAMP-mediated signaling / molecular condensate scaffold activity / determination of adult lifespan / positive regulation of cellular senescence / site of double-strand break / double-stranded DNA binding / defense response to virus / nuclear body / DNA repair / innate immune response / DNA damage response / chromatin binding / GTP binding / protein homodimerization activity / DNA binding / nucleoplasm / ATP binding / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 Mab-21-like, nucleotidyltransferase domain / Mab-21-like, HhH/H2TH-like domain / Mab-21 protein HhH/H2TH-like domain / Mab-21 protein nucleotidyltransferase domain / Mab-21-like / Mab-21 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.508 Å 詳細データ登録者 Leibrock, L. / Benz, J. / Groebke-Zbinden, K. / Rudolph, M.G. 資金援助 スイス, 1件 詳細 詳細を隠す組織 認可番号 国 F. Hoffmann-La Roche LTD スイス
引用ジャーナル : To be published タイトル : Crystal Structure of a human cyclic GMP-AMP synthase complex著者 : Groebke-Zbinden, K. / Vandemeulebroucke, A. / Hilbert, M. / Rudolph, M.G. 履歴 登録 2023年2月8日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2024年2月21日 Provider : repository / タイプ : Initial release