登録情報 | データベース: PDB / ID: 7fgm |
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タイトル | The complex crystals structure of the FAF1 UBL1_L-Hsp70 NBD with ADP and phosphate |
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要素 | - FAS-associated factor 1
- Heat shock 70 kDa protein 1A
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キーワード | CHAPERONE/INHIBITOR / CHAPERONE-INHIBITOR COMPLEX |
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機能・相同性 | 機能・相同性情報
ooplasm / positive regulation of endoribonuclease activity / denatured protein binding / positive regulation of extrinsic apoptotic signaling pathway via death domain receptors / CD95 death-inducing signaling complex / cytoplasmic sequestering of NF-kappaB / cellular heat acclimation / death receptor agonist activity / negative regulation of inclusion body assembly / Viral RNP Complexes in the Host Cell Nucleus ...ooplasm / positive regulation of endoribonuclease activity / denatured protein binding / positive regulation of extrinsic apoptotic signaling pathway via death domain receptors / CD95 death-inducing signaling complex / cytoplasmic sequestering of NF-kappaB / cellular heat acclimation / death receptor agonist activity / negative regulation of inclusion body assembly / Viral RNP Complexes in the Host Cell Nucleus / positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway / C3HC4-type RING finger domain binding / positive regulation of microtubule nucleation / ATP-dependent protein disaggregase activity / misfolded protein binding / regulation of mitotic spindle assembly / negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / positive regulation of tumor necrosis factor-mediated signaling pathway / protein kinase regulator activity / VCP-NPL4-UFD1 AAA ATPase complex / transcription regulator inhibitor activity / aggresome / lysosomal transport / cellular response to steroid hormone stimulus / regulation of protein catabolic process / mRNA catabolic process / regulation of protein ubiquitination / chaperone cofactor-dependent protein refolding / HSF1-dependent transactivation / response to unfolded protein / NF-kappaB binding / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / chaperone-mediated protein complex assembly / Regulation of HSF1-mediated heat shock response / Attenuation phase / cellular response to unfolded protein / regulation of cell adhesion / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / ERAD pathway / ATP metabolic process / protein folding chaperone / inclusion body / negative regulation of protein ubiquitination / heat shock protein binding / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / centriole / positive regulation of RNA splicing / positive regulation of erythrocyte differentiation / positive regulation of DNA replication / ubiquitin binding / AUF1 (hnRNP D0) binds and destabilizes mRNA / positive regulation of interleukin-8 production / G protein-coupled receptor binding / ATP-dependent protein folding chaperone / negative regulation of transforming growth factor beta receptor signaling pathway / positive regulation of protein-containing complex assembly / PKR-mediated signaling / negative regulation of cell growth / histone deacetylase binding / positive regulation of protein catabolic process / transcription corepressor activity / disordered domain specific binding / unfolded protein binding / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / nuclear envelope / virus receptor activity / positive regulation of NF-kappaB transcription factor activity / cellular response to heat / cellular response to oxidative stress / protein refolding / proteasome-mediated ubiquitin-dependent protein catabolic process / vesicle / ficolin-1-rich granule lumen / receptor ligand activity / blood microparticle / protein stabilization / nuclear speck / ribonucleoprotein complex / cadherin binding / positive regulation of apoptotic process / protein domain specific binding / negative regulation of cell population proliferation / focal adhesion / signaling receptor binding / centrosome / apoptotic process / ubiquitin protein ligase binding / Neutrophil degranulation / positive regulation of gene expression / negative regulation of apoptotic process / protein kinase binding / perinuclear region of cytoplasm / enzyme binding / negative regulation of transcription by RNA polymerase II / endoplasmic reticulum / ATP hydrolysis activity / protein-containing complex / mitochondrion / RNA binding / extracellular space類似検索 - 分子機能 : / Fas-associated factor 1 / FAS-associated factor 1-like, UBX domain / FAF1, UBA-like domain / UAS / UAS / Domain present in ubiquitin-regulatory proteins / UBX domain / UBX domain / UBX domain profile. ...: / Fas-associated factor 1 / FAS-associated factor 1-like, UBX domain / FAF1, UBA-like domain / UAS / UAS / Domain present in ubiquitin-regulatory proteins / UBX domain / UBX domain / UBX domain profile. / UBA-like domain / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein / Heat shock protein 70kD, C-terminal domain superfamily / ATPase, nucleotide binding domain / Thioredoxin-like superfamily / Ubiquitin-like domain superfamily類似検索 - ドメイン・相同性 ADENOSINE-5'-DIPHOSPHATE / PHOSPHATE ION / Heat shock 70 kDa protein 1A / FAS-associated factor 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.2 Å |
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データ登録者 | Kim, E.E. / ParK, J.K. / Shin, S.C. |
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資金援助 | 韓国, 1件 組織 | 認可番号 | 国 |
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National Research Foundation (NRF, Korea) | | 韓国 |
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引用 | ジャーナル: J Mol Cell Biol / 年: 2022 タイトル: The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation 著者: Song, S. / Park, J.K. / Shin, S.C. / Lee, J.J. / Hong, S.K. / Song, I.K. / Kim, B. / Song, E.J. / Lee, K.J. / Kim, E.E. |
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履歴 | 登録 | 2021年7月27日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2022年7月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年8月9日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.title / _citation.year |
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改定 1.2 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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