Entry Database : PDB / ID : 7cbg Structure visualization Downloads & linksTitle Crystal structure of threonyl-tRNA synthetase (ThrRS) from Salmonella enterica in complex with an inhibitor ComponentsThreonine--tRNA ligase Details Keywords LIGASE/INHIBITOR / Ligase-Inhibitor ComplexFunction / homology Function and homology informationFunction Domain/homology Component
threonine-tRNA ligase / threonyl-tRNA aminoacylation / threonine-tRNA ligase activity / tRNA binding / ATP binding / metal ion binding / cytosol Similarity search - Function Threonine-tRNA ligase, class IIa / Threonine-tRNA ligase catalytic core domain / Threonyl/alanyl tRNA synthetase, SAD / Threonyl and Alanyl tRNA synthetase second additional domain / Threonyl and Alanyl tRNA synthetase second additional domain / : / TGS domain / Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily / TGS domain profile. / TGS ... Threonine-tRNA ligase, class IIa / Threonine-tRNA ligase catalytic core domain / Threonyl/alanyl tRNA synthetase, SAD / Threonyl and Alanyl tRNA synthetase second additional domain / Threonyl and Alanyl tRNA synthetase second additional domain / : / TGS domain / Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily / TGS domain profile. / TGS / TGS-like / Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) / tRNA synthetase class II core domain (G, H, P, S and T) / Anticodon-binding / Anticodon binding domain / Anticodon-binding domain superfamily / Aminoacyl-tRNA synthetase, class II / Aminoacyl-transfer RNA synthetases class-II family profile. / Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) / Beta-grasp domain superfamily Similarity search - Domain/homologyBiological species Salmonella enterica subsp. enterica serovar Cubana str. 76814 (bacteria)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.5 Å DetailsAuthors Guo, J. / Chen, B. / Zhou, H. Funding support China, 1items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China (NSFC) 81773636 China
CitationJournal : Eur.J.Med.Chem. / Year : 2020Title : Structure-guided optimization and mechanistic study of a class of quinazolinone-threonine hybrids as antibacterial ThrRS inhibitors.Authors : Guo, J. / Chen, B. / Yu, Y. / Cheng, B. / Ju, Y. / Tang, J. / Cai, Z. / Gu, Q. / Xu, J. / Zhou, H. History Deposition Jun 12, 2020 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Oct 7, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Nov 29, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less