登録情報 データベース : PDB / ID : 7c2w 構造の表示 ダウンロードとリンクタイトル Crystal Structure of IRAK4 kinase in complex with a small molecule inhibitor 要素Interleukin-1 receptor-associated kinase 4 詳細 キーワード TRANSFERASE/TRANSFERASE INHIBITOR / IRAK4 / Inhibitor / CA-4948 / Kinase / CELL CYCLE / TRANSFERASE-TRANSFERASE INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding ... IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding / MyD88-dependent toll-like receptor signaling pathway / interleukin-1-mediated signaling pathway / IRAK4 deficiency (TLR2/4) / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / toll-like receptor 4 signaling pathway / toll-like receptor signaling pathway / extrinsic component of plasma membrane / JNK cascade / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / positive regulation of smooth muscle cell proliferation / cytokine-mediated signaling pathway / Interleukin-1 signaling / PIP3 activates AKT signaling / kinase activity / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / cellular response to lipopolysaccharide / positive regulation of canonical NF-kappaB signal transduction / endosome membrane / non-specific serine/threonine protein kinase / intracellular signal transduction / phosphorylation / innate immune response / protein serine kinase activity / protein serine/threonine kinase activity / protein kinase binding / cell surface / magnesium ion binding / extracellular space / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 Interleukin-1 receptor-associated kinase 4 / IRAK4, Death domain / Death-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性 Chem-FJ9 / Interleukin-1 receptor-associated kinase 4 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 3.2 Å 詳細データ登録者 Krishnamurthy, N.R. / Anirudha, L. 引用ジャーナル : Acs Med.Chem.Lett. / 年 : 2020タイトル : Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies.著者: Gummadi, V.R. / Boruah, A. / Ainan, B.R. / Vare, B.R. / Manda, S. / Gondle, H.P. / Kumar, S.N. / Mukherjee, S. / Gore, S.T. / Krishnamurthy, N.R. / Marappan, S. / Nayak, S.S. / Nellore, K. / ... 著者 : Gummadi, V.R. / Boruah, A. / Ainan, B.R. / Vare, B.R. / Manda, S. / Gondle, H.P. / Kumar, S.N. / Mukherjee, S. / Gore, S.T. / Krishnamurthy, N.R. / Marappan, S. / Nayak, S.S. / Nellore, K. / Balasubramanian, W.R. / Bhumireddy, A. / Giri, S. / Gopinath, S. / Samiulla, D.S. / Daginakatte, G. / Basavaraju, A. / Chelur, S. / Eswarappa, R. / Belliappa, C. / Subramanya, H.S. / Booher, R.N. / Ramachandra, M. / Samajdar, S. 履歴 登録 2020年5月9日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2020年11月25日 Provider : repository / タイプ : Initial release改定 1.1 2020年12月30日 Group : Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title 改定 1.2 2023年11月29日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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