登録情報 データベース : PDB / ID : 6yo8 構造の表示 ダウンロードとリンクタイトル Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide 要素14-3-3 protein zeta/delta Glucocorticoid receptor 詳細キーワード PROTEIN BINDING / 14-3-3 protein zeta/delta / glucocorticoid receptor / protein-peptide complex / protein-protein interaction機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Regulation of NPAS4 gene transcription / Golgi reassembly / synaptic target recognition / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / steroid hormone binding / PTK6 Expression / neuroinflammatory response / glucocorticoid metabolic process / NOTCH4 Activation and Transmission of Signal to the Nucleus ... Regulation of NPAS4 gene transcription / Golgi reassembly / synaptic target recognition / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / steroid hormone binding / PTK6 Expression / neuroinflammatory response / glucocorticoid metabolic process / NOTCH4 Activation and Transmission of Signal to the Nucleus / respiratory system process / establishment of Golgi localization / tube formation / microglia differentiation / mammary gland duct morphogenesis / regulation of synapse maturation / maternal behavior / Rap1 signalling / astrocyte differentiation / cellular response to glucocorticoid stimulus / negative regulation of protein localization to nucleus / motor behavior / KSRP (KHSRP) binds and destabilizes mRNA / adrenal gland development / regulation of gluconeogenesis / cellular response to steroid hormone stimulus / GP1b-IX-V activation signalling / Regulation of localization of FOXO transcription factors / phosphoserine residue binding / Interleukin-3, Interleukin-5 and GM-CSF signaling / Activation of BAD and translocation to mitochondria / estrogen response element binding / protein targeting / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / cellular response to glucose starvation / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / nuclear receptor-mediated steroid hormone signaling pathway / core promoter sequence-specific DNA binding / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / RHO GTPases activate PKNs / cellular response to transforming growth factor beta stimulus / negative regulation of TORC1 signaling / negative regulation of innate immune response / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / protein sequestering activity / steroid binding / TBP-class protein binding / ERK1 and ERK2 cascade / regulation of ERK1 and ERK2 cascade / hippocampal mossy fiber to CA3 synapse / cellular response to dexamethasone stimulus / synaptic transmission, glutamatergic / chromosome segregation / Translocation of SLC2A4 (GLUT4) to the plasma membrane / Deactivation of the beta-catenin transactivating complex / TP53 Regulates Metabolic Genes / RNA polymerase II transcription regulatory region sequence-specific DNA binding / lung development / Negative regulation of NOTCH4 signaling / SUMOylation of intracellular receptors / Hsp90 protein binding / regulation of protein stability / DNA-binding transcription repressor activity, RNA polymerase II-specific / spindle / positive regulation of miRNA transcription / Nuclear Receptor transcription pathway / positive regulation of neuron apoptotic process / nuclear receptor activity / Regulation of RUNX2 expression and activity / sequence-specific double-stranded DNA binding / protein localization / melanosome / Circadian Clock / chromatin organization / gene expression / DNA-binding transcription activator activity, RNA polymerase II-specific / angiogenesis / DNA-binding transcription factor binding / vesicle / transmembrane transporter binding / blood microparticle / Potential therapeutics for SARS / DNA-binding transcription factor activity, RNA polymerase II-specific / nuclear speck / mitochondrial matrix / cadherin binding / protein phosphorylation / DNA-binding transcription factor activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / protein domain specific binding / cell division / focal adhesion / negative regulation of DNA-templated transcription / centrosome / glutamatergic synapse / ubiquitin protein ligase binding / synapse / regulation of DNA-templated transcription / negative regulation of apoptotic process 類似検索 - 分子機能 Glucocorticoid receptor / Glucocorticoid receptor / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein ... Glucocorticoid receptor / Glucocorticoid receptor / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / : / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Ligand-binding domain of nuclear hormone receptor / Zinc finger, NHR/GATA-type 類似検索 - ドメイン・相同性 Glucocorticoid receptor / 14-3-3 protein zeta/delta 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.09 Å 詳細データ登録者 Munier, C.C. / Edman, K. / Perry, M.W.D. / Ottmann, C. 資金援助 オランダ, 1件 詳細 詳細を隠す組織 認可番号 国 European Commission 675179 オランダ
引用ジャーナル : J.Biol.Chem. / 年 : 2021タイトル : Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.著者 : Munier, C.C. / De Maria, L. / Edman, K. / Gunnarsson, A. / Longo, M. / MacKintosh, C. / Patel, S. / Snijder, A. / Wissler, L. / Brunsveld, L. / Ottmann, C. / Perry, M.W.D. 履歴 登録 2020年4月14日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2021年3月24日 Provider : repository / タイプ : Initial release改定 1.1 2021年4月7日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.page_first / _citation.page_last ... _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title 改定 1.2 2021年7月21日 Group : Database references / カテゴリ : citation / Item : _citation.journal_volume改定 1.3 2024年1月24日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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