登録情報 データベース : PDB / ID : 6x5y 構造の表示 ダウンロードとリンクタイトル IDO1 in complex with compound 4 要素Indoleamine 2,3-dioxygenase 1 詳細 キーワード OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor / INDOLEAMINE DIOXYGENASE / IDO1 / INHIBITOR COMPLEX / OXIDOREDUCTASE / OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
indoleamine 2,3-dioxygenase / smooth muscle contractile fiber / indoleamine 2,3-dioxygenase activity / positive regulation of chronic inflammatory response / kynurenic acid biosynthetic process / tryptophan 2,3-dioxygenase activity / positive regulation of T cell tolerance induction / tryptophan catabolic process to kynurenine / stereocilium bundle / positive regulation of type 2 immune response ... indoleamine 2,3-dioxygenase / smooth muscle contractile fiber / indoleamine 2,3-dioxygenase activity / positive regulation of chronic inflammatory response / kynurenic acid biosynthetic process / tryptophan 2,3-dioxygenase activity / positive regulation of T cell tolerance induction / tryptophan catabolic process to kynurenine / stereocilium bundle / positive regulation of type 2 immune response / 'de novo' NAD biosynthetic process from tryptophan / tryptophan catabolic process / Tryptophan catabolism / negative regulation of T cell apoptotic process / positive regulation of T cell apoptotic process / swimming behavior / negative regulation of interleukin-10 production / multicellular organismal response to stress / negative regulation of T cell proliferation / T cell proliferation / positive regulation of interleukin-12 production / female pregnancy / response to lipopolysaccharide / electron transfer activity / inflammatory response / heme binding / metal ion binding / cytosol / cytoplasm 類似検索 - 分子機能 Indoleamine 2,3-dioxygenase / Indoleamine 2,3-dioxygenase / Indoleamine 2,3-dioxygenase signature 1. / Indoleamine 2,3-dioxygenase signature 2. / Tryptophan/Indoleamine 2,3-dioxygenase-like 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.65 Å 詳細データ登録者 Lesburg, C.A. / Lammens, A. 引用ジャーナル : To Be Published タイトル : Utilization of MetID and Structural Data to Guide Placement of Spiro and Fused Cyclopropyl Groups for the Synthesis of Low Dose IDO1 Inhibitors著者: Hopkins, B. / Zhang, H. / Bharathan, I. / Li, D. / Pu, Q. / Zhou, H. / Martinot, T. / Fradera, X. / Lammens, A. / Lesburg, C.A. / Ballard, J. / Knemeyer, I. / Otte, K. / Solban, N. / Vincent, ... 著者 : Hopkins, B. / Zhang, H. / Bharathan, I. / Li, D. / Pu, Q. / Zhou, H. / Martinot, T. / Fradera, X. / Lammens, A. / Lesburg, C.A. / Ballard, J. / Knemeyer, I. / Otte, K. / Solban, N. / Vincent, S. / Miller, J.R. / Cheng, M. / Geda, P. / Smotrov, N. / Song, X. / Spacciapoli, P. / Bennett, D.J. / Han, Y. 履歴 登録 2020年5月27日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2021年6月2日 Provider : repository / タイプ : Initial release改定 1.1 2024年4月3日 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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