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- PDB-6v18: immune receptor complex -

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Open data


ID or keywords:

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Basic information

Entry
Database: PDB / ID: 6v18
Titleimmune receptor complex
Components
  • (HLA class II histocompatibility antigen, ...) x 2
  • Fibrinogen beta
  • M141 TCR alpha chain
  • M141 TCR beta chain
KeywordsIMMUNE SYSTEM / Immune receptor / Complex
Function / homology
Function and homology information


sugar-phosphatase activity / regulation of interleukin-4 production / regulation of interleukin-10 production / myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane / regulation of T-helper cell differentiation / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / MHC class II receptor activity / positive regulation of T cell mediated immune response to tumor cell ...sugar-phosphatase activity / regulation of interleukin-4 production / regulation of interleukin-10 production / myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane / regulation of T-helper cell differentiation / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / MHC class II receptor activity / positive regulation of T cell mediated immune response to tumor cell / positive regulation of CD4-positive, alpha-beta T cell activation / antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / positive regulation of memory T cell differentiation / CD4 receptor binding / positive regulation of monocyte differentiation / positive regulation of kinase activity / inflammatory response to antigenic stimulus / intermediate filament / T-helper 1 type immune response / polysaccharide binding / transport vesicle membrane / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / positive regulation of insulin secretion involved in cellular response to glucose stimulus / humoral immune response / macrophage differentiation / negative regulation of type II interferon production / Generation of second messenger molecules / immunological synapse / PD-1 signaling / epidermis development / T cell receptor binding / negative regulation of T cell proliferation / detection of bacterium / MHC class II antigen presentation / trans-Golgi network membrane / negative regulation of inflammatory response to antigenic stimulus / lumenal side of endoplasmic reticulum membrane / protein tetramerization / clathrin-coated endocytic vesicle membrane / ER to Golgi transport vesicle membrane / structural constituent of cytoskeleton / cognition / peptide antigen assembly with MHC class II protein complex / MHC class II protein complex / positive regulation of T cell mediated cytotoxicity / peptide antigen binding / antigen processing and presentation of exogenous peptide antigen via MHC class II / positive regulation of immune response / Interferon gamma signaling / endocytic vesicle membrane / positive regulation of T cell activation / Downstream TCR signaling / MHC class II protein complex binding / late endosome membrane / T cell receptor signaling pathway / outer membrane-bounded periplasmic space / early endosome membrane / positive regulation of canonical NF-kappaB signal transduction / adaptive immune response / positive regulation of MAPK cascade / lysosome / positive regulation of ERK1 and ERK2 cascade / positive regulation of viral entry into host cell / immune response / positive regulation of protein phosphorylation / lysosomal membrane / Golgi membrane / external side of plasma membrane / positive regulation of DNA-templated transcription / cell surface / signal transduction / extracellular space / extracellular exosome / membrane / plasma membrane
Similarity search - Function
Histidine acid phosphatases active site signature. / : / Histidine acid phosphatases phosphohistidine signature. / Histidine acid phosphatase active site / Histidine phosphatase superfamily, clade-2 / Histidine phosphatase superfamily (branch 2) / MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal ...Histidine acid phosphatases active site signature. / : / Histidine acid phosphatases phosphohistidine signature. / Histidine acid phosphatase active site / Histidine phosphatase superfamily, clade-2 / Histidine phosphatase superfamily (branch 2) / MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal / Histidine phosphatase superfamily / MHC classes I/II-like antigen recognition protein / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
HLA class II histocompatibility antigen, DR alpha chain / HLA class II histocompatibility antigen, DRB1 beta chain / Acid glucose-1-phosphate phosphatase / HLA class II histocompatibility antigen, DRB1 beta chain
Similarity search - Component
Biological speciesHomo sapiens (human)
Mus musculus (house mouse)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.35 Å
AuthorsLim, J.J. / Rossjohn, J.
Funding support Australia, 1items
OrganizationGrant numberCountry
Australian Research Council (ARC)CE140100011 Australia
CitationJournal: Sci Immunol / Year: 2021
Title: The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Authors: Lim, J.J. / Jones, C.M. / Loh, T.J. / Ting, Y.T. / Zareie, P. / Loh, K.L. / Felix, N.J. / Suri, A. / McKinnon, M. / Stevenaert, F. / Sharma, R.K. / Klareskog, L. / Malmstrom, V. / Baker, D.G. ...Authors: Lim, J.J. / Jones, C.M. / Loh, T.J. / Ting, Y.T. / Zareie, P. / Loh, K.L. / Felix, N.J. / Suri, A. / McKinnon, M. / Stevenaert, F. / Sharma, R.K. / Klareskog, L. / Malmstrom, V. / Baker, D.G. / Purcell, A.W. / Reid, H.H. / La Gruta, N.L. / Rossjohn, J.
History
DepositionNov 20, 2019Deposition site: RCSB / Processing site: RCSB
Revision 1.0Nov 25, 2020Provider: repository / Type: Initial release
Revision 1.1Jun 9, 2021Group: Database references / Category: citation / citation_author
Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
Revision 1.2Oct 11, 2023Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Revision 2.0Nov 15, 2023Group: Atomic model / Data collection / Derived calculations
Category: atom_site / atom_site_anisotrop ...atom_site / atom_site_anisotrop / chem_comp_atom / chem_comp_bond / pdbx_validate_rmsd_angle / struct_conn
Item: _atom_site.auth_atom_id / _atom_site.label_atom_id ..._atom_site.auth_atom_id / _atom_site.label_atom_id / _atom_site_anisotrop.pdbx_auth_atom_id / _atom_site_anisotrop.pdbx_label_atom_id / _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_1 / _chem_comp_bond.atom_id_2 / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr2_label_atom_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: HLA class II histocompatibility antigen, DR alpha chain
B: HLA class II histocompatibility antigen, DRB1-4 beta chain
C: Fibrinogen beta
D: M141 TCR alpha chain
E: M141 TCR beta chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)98,41820
Polymers96,7795
Non-polymers1,64015
Water3,135174
1


  • Idetical with deposited unit
  • defined by author
  • Evidence: surface plasmon resonance
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)147.878, 56.266, 128.915
Angle α, β, γ (deg.)90.000, 91.354, 90.000
Int Tables number5
Space group name H-MC121
Space group name HallC2y
Symmetry operation#1: x,y,z
#2: -x,y,-z
#3: x+1/2,y+1/2,z
#4: -x+1/2,y+1/2,-z

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Components

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HLA class II histocompatibility antigen, ... , 2 types, 2 molecules AB

#1: Protein HLA class II histocompatibility antigen, DR alpha chain / MHC class II antigen DRA


Mass: 21919.594 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: HLA-DRA, HLA-DRA1 / Production host: Homo sapiens (human) / References: UniProt: P01903
#2: Protein HLA class II histocompatibility antigen, DRB1-4 beta chain / MHC class II antigen DRB1*4 / DR4


Mass: 23080.488 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: HLA-DRB1 / Production host: Homo sapiens (human) / References: UniProt: P13760, UniProt: P01911*PLUS

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Protein , 2 types, 2 molecules DE

#4: Protein M141 TCR alpha chain


Mass: 22920.254 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Mus musculus (house mouse) / Production host: Escherichia coli BL21(DE3) (bacteria)
#5: Protein M141 TCR beta chain


Mass: 27565.814 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Mus musculus (house mouse) / Production host: Escherichia coli BL21(DE3) (bacteria)

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Protein/peptide / Sugars , 2 types, 3 molecules C

#3: Protein/peptide Fibrinogen beta


Mass: 1292.445 Da / Num. of mol.: 1 / Source method: obtained synthetically / Source: (synth.) Homo sapiens (human) / References: UniProt: P02675*PLUS
#6: Sugar ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Non-polymers , 2 types, 187 molecules

#7: Chemical
ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL


Mass: 92.094 Da / Num. of mol.: 13
Source method: isolated from a genetically manipulated source
Formula: C3H8O3
#8: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 174 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.77 Å3/Da / Density % sol: 55.6 %
Crystal growTemperature: 293 K / Method: vapor diffusion, hanging drop / Details: 0.2 M trisodium citrate, 20% PEG 3350

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: Australian Synchrotron / Beamline: MX2 / Wavelength: 0.9537 Å
DetectorType: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Feb 20, 2019
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9537 Å / Relative weight: 1
ReflectionResolution: 2.35→48.833 Å / Num. obs: 44286 / % possible obs: 99.2 % / Redundancy: 7.1 % / Biso Wilson estimate: 43.5169659748 Å2 / CC1/2: 0.996 / Rmerge(I) obs: 0.137 / Net I/σ(I): 9.3
Reflection shellResolution: 2.35→2.43 Å / Rmerge(I) obs: 1.446 / Num. unique obs: 4318 / CC1/2: 0.685

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Processing

Software
NameVersionClassification
PHENIX1.10.1_2155refinement
XDSdata reduction
Aimlessdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 6BIL

6bil


Resolution: 2.35→48.83 Å / SU ML: 0.302337054318 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 25.6426909936
RfactorNum. reflection% reflection
Rfree0.2307 2250 5.08279305126 %
Rwork0.1931 --
obs0.1949 44267 99.1955362345 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å
Displacement parametersBiso mean: 58.6158192028 Å2
Refinement stepCycle: LAST / Resolution: 2.35→48.83 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6442 0 106 174 6722
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.007167989833246714
X-RAY DIFFRACTIONf_angle_d0.8497643847199126
X-RAY DIFFRACTIONf_chiral_restr0.0506438257418991
X-RAY DIFFRACTIONf_plane_restr0.005117777913311178
X-RAY DIFFRACTIONf_dihedral_angle_d21.20724140252397
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.35-2.40110.27711430.27532619X-RAY DIFFRACTION99.9638074557
2.4011-2.45690.3008196539311450.2826707732472574X-RAY DIFFRACTION97.4901398351
2.4569-2.51840.3191862204571660.2713631931432558X-RAY DIFFRACTION99.9633027523
2.5184-2.58650.32539081603960.2621698300812621X-RAY DIFFRACTION97.7689816481
2.5865-2.66260.3279151354841330.2579266319992617X-RAY DIFFRACTION99.2063492063
2.6626-2.74850.287107446851430.2433135332892581X-RAY DIFFRACTION98.9825581395
2.7485-2.84670.2609814601411550.2302474646612584X-RAY DIFFRACTION98.5606333213
2.8467-2.96070.2526413380241540.2014245457542608X-RAY DIFFRACTION98.9609458975
2.9607-3.09540.2382138518361400.195350580152614X-RAY DIFFRACTION99.9637023593
3.0954-3.25860.2387910670861640.1946458961752607X-RAY DIFFRACTION99.1768074445
3.2586-3.46270.2279489990971220.1819177286712636X-RAY DIFFRACTION99.2800575954
3.4627-3.730.2193254115971510.166643281592640X-RAY DIFFRACTION99.4299964375
3.73-4.10520.2152391270621390.1665362528962611X-RAY DIFFRACTION99.3138317082
4.1052-4.69880.1818502287431170.1537949687582706X-RAY DIFFRACTION99.5767195767
4.6988-5.91830.1847672842621450.1755712094422670X-RAY DIFFRACTION99.7873094647
5.9183-48.830.2275177587431370.1980464157212771X-RAY DIFFRACTION99.6914638327
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
13.390527512060.260770425297-0.4161955381942.465608587620.2773151514683.728515058120.01317805502110.430888472365-0.18438012942-0.04181113041820.1343401107030.01625958360670.104799420195-0.1753988173910.03747852219930.448784201528-0.0521848677431-0.00835912915380.496239614848-0.08834667376640.361349960084-25.8251438912-14.26691671118.4554498762
22.09774954056-0.3274274684030.6892848051172.346838200880.3448752830653.78781766338-0.1008288729850.325535423095-0.409366972501-0.02150723438720.14346130522-0.2237912989810.4279535855650.426485012903-0.1332287889310.4570469604640.01037868314090.0388529858880.509415157158-0.0831854117660.508467952342-15.230584244-18.50737300521.5295116103
31.050549477080.330501378398-0.2504457659391.502329953681.223771822292.202526404320.006534345487470.4301533428-0.262140134332-0.09968623974860.01260197334890.3742976685670.203134949138-0.5506228482060.1081133484440.401544027514-0.107429894604-0.02129321742230.571996469339-0.04930913046610.480368701509-38.5395313888-15.770507790824.3747026291
40.7571410152990.548012147019-0.7835138966821.785713870411.30572787432.947721839580.07453256672610.493107002687-0.488743906759-0.4668022686970.169263071309-0.05372361224870.7475877535690.485140747251-0.158883317930.8522699213170.0277513528874-0.007629974890920.852137852597-0.3417502509060.712647234763-18.0820530218-31.710352737-0.245896012451
50.1469503861610.280495837409-0.1963278445980.9954592398530.8866752734641.38454726453-0.2930988850310.486180729785-0.570893089551-0.1385838556670.0859669112127-0.1255711978870.834706796974-0.0480893463061-0.03953040674390.748684902155-0.1311158780450.0847226939930.772762514313-0.3164466944160.734984618461-25.4261654353-33.6983742019.34011017186
61.01141343339-0.275242735995-0.1655302456572.002184311071.060493971582.35860773960.03344505594720.336937111395-0.476527961575-0.351387287870.051699622752-0.0512480247650.726464607538-0.160389725149-0.01499766367820.819828086135-0.103678706867-0.04603307704730.762018925958-0.2046725358720.660319013889-27.0585960453-31.17487562886.84797873565
72.756744246910.974367402693-0.3895882390031.934973460230.4896687588732.542245503770.009654345805780.288934102752-0.462515357986-0.277653566856-0.0667798066394-0.05986865954540.282772639294-0.4205313447730.03614382824720.398320164505-0.0100093276698-0.01186337968990.546720831457-0.06110160258210.407291585645-33.4201100883-14.126928095718.193543337
80.706522401095-0.6568435449570.7537956222412.190053118290.9671374454562.64881552069-0.06088976181990.510392169032-0.136369350138-0.409150956744-0.08879538867350.333088987629-0.133115090886-0.6182910021220.0937181384440.4317793119060.0391934081663-0.0291673241550.590936115331-0.02082100617570.452167419368-34.0427562533-1.1805313545318.7284925696
92.80571866464-1.33720049264-2.109456771861.45809985710.8815518116463.8565596437-0.292462166561-0.06792342222960.1360584524530.01939318203310.3501247235070.0263366717732-0.3861598283840.278444473648-0.05148844148840.4303300595990.0117715104432-0.02711376838910.4248215719410.03969925401260.452701848321-26.64645725224.8634453819227.361075978
101.17763168996-0.190917630805-0.1071023860811.431008532231.128814191862.699760847080.1382589443910.580310169692-0.236204663643-0.4207631588220.246577017303-0.3257258962290.0711735881520.338218978603-0.2837978603020.61084453911-0.01681969122320.1186366666820.810865864146-0.1556944084460.556878263986-10.4296809981-14.92898155125.13795786728
110.869747512402-0.0891117602917-0.08912087461580.9037969871520.7470308542662.355573959730.3199632372541.13480762924-0.00812270313514-0.4658314653150.190522572423-0.0810442259126-0.0765491372551-0.150343468844-0.1261946975750.764623829458-0.02934363961670.08528784167081.28849026226-0.1969642280850.63164896591-13.0907171384-18.9120986962-9.87036304279
120.0906367127024-0.0494281092796-0.1661597550650.5288141339551.418863899613.56818008725-0.09934310690211.07458936597-0.273348032084-0.8589642059710.2608916138620.202232003502-0.4318369107710.107379758117-0.2402143526510.764404738738-0.05185559569090.1281984043861.35952743685-0.2072163801360.657697247733-4.25715129725-16.3298670116-8.92940141658
130.1154030285930.1315004130190.5261634893342.010570397180.5663884136692.44193101062-0.1330225914480.214802481694-0.235717278187-0.4231514769070.247373352198-0.106551878273-0.0966945786348-0.111907348727-0.03495638061280.413014494232-0.01073470256940.07610324987450.42687865189-0.03598135043820.494937815678-25.976143908-6.3462710564227.7094353995
141.721987520590.9972969729090.9400852904862.513598499511.248341391471.56689231968-0.03532245136740.2551104561430.00941869978758-0.1593751872360.151700645697-0.36876426836-0.1801507157810.215795677798-0.1865555078420.317658588448-0.03621266084690.08593089700860.3616505105850.01516386441690.418257669616-11.24244775668.2782049007842.3725599876
150.310527618098-0.0660467841267-0.01372457755521.837518371142.626366538683.394958679990.0375652257290.06010563353330.260787215275-0.3028621553090.115924798272-0.102064648307-0.5518685308560.00414531740541-0.08864908529390.4084100336250.01791298760740.08615118410450.3016911399830.05631994175790.5833613603-10.474276137426.701227121159.2545902509
162.50045475514-0.08434479967240.2280253316022.808729406710.03841501626242.36117906231-0.0135385722763-0.125869825460.1266846369380.1092386701830.116213892561-0.0924490516775-0.07954500451420.0787761344868-0.1461014742030.3472933336190.01248653967630.03444418359640.296899883635-0.01742933174790.502253413551-12.688064852523.861480214874.827240433
170.8277653943280.327936764758-0.6174805872551.33757863718-0.03663590728233.836880434420.02383556713450.00232608049635-0.1819800981960.110239769168-0.01693229968440.02854571990490.290935297276-0.00524006478516-0.01048030614570.306986706442-0.009366316465460.06202223003580.2806038025990.008867430998580.456292268893-27.1135217474-5.9044940162949.9124249285
181.59952717485-0.417463930393-0.03036254610072.316744865413.210795282494.36246058116-0.0230392135778-0.230753051787-0.2008904113950.5161643811290.132463812913-0.3794820237490.6929635855660.0528839771892-0.02940489494310.436616113241-0.01788016472790.0506323098410.2576314698340.03612441962820.380211587256-25.6113445612-3.1219698755571.4594708881
191.317499333350.3818749683240.1825787386512.372961276020.554436389961.297049634310.003719669719-0.0003238334262770.08844117713710.05969638177040.0320273495757-0.148723090669-0.0445632721997-0.049640055612-0.01035531251340.3364963248650.01416514619220.08749180335010.278903867461-0.002609214689350.433787670673-25.11234572919.969687130872.334513303
201.64917126298-0.604480066301-0.3155361374383.454867673540.1945267061682.610657806090.107632121099-0.140172356678-0.1773737963860.483672779816-0.2299019274640.4942658206280.408572185341-0.3252962924630.08927879626780.360588290477-0.06943406674620.105522280330.375949809041-0.003221029762110.40003152316-34.15950763586.8487167658676.7829591417
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1chain 'A' and (resid 2 through 26 )
2X-RAY DIFFRACTION2chain 'A' and (resid 27 through 55 )
3X-RAY DIFFRACTION3chain 'A' and (resid 56 through 87 )
4X-RAY DIFFRACTION4chain 'A' and (resid 88 through 101 )
5X-RAY DIFFRACTION5chain 'A' and (resid 102 through 133 )
6X-RAY DIFFRACTION6chain 'A' and (resid 134 through 180 )
7X-RAY DIFFRACTION7chain 'B' and (resid 2 through 18 )
8X-RAY DIFFRACTION8chain 'B' and (resid 19 through 62 )
9X-RAY DIFFRACTION9chain 'B' and (resid 63 through 77 )
10X-RAY DIFFRACTION10chain 'B' and (resid 78 through 122 )
11X-RAY DIFFRACTION11chain 'B' and (resid 123 through 170 )
12X-RAY DIFFRACTION12chain 'B' and (resid 171 through 188 )
13X-RAY DIFFRACTION13chain 'C' and (resid 69 through 81 )
14X-RAY DIFFRACTION14chain 'D' and (resid 1 through 120 )
15X-RAY DIFFRACTION15chain 'D' and (resid 121 through 134 )
16X-RAY DIFFRACTION16chain 'D' and (resid 135 through 218 )
17X-RAY DIFFRACTION17chain 'E' and (resid 3 through 121 )
18X-RAY DIFFRACTION18chain 'E' and (resid 122 through 136 )
19X-RAY DIFFRACTION19chain 'E' and (resid 137 through 227 )
20X-RAY DIFFRACTION20chain 'E' and (resid 228 through 257 )

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