登録情報 | データベース: PDB / ID: 6uya |
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タイトル | Crystal structure of Compound 19 bound to IRAK4 |
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要素 | Interleukin-1 receptor-associated kinase 4 |
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キーワード | SIGNALING PROTEIN/INHIBITOR / kinase / inflammation / lupus / immunology / inhibitor / cancer / SIGNALING PROTEIN / SIGNALING PROTEIN-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding ...IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding / MyD88-dependent toll-like receptor signaling pathway / interleukin-1-mediated signaling pathway / IRAK4 deficiency (TLR2/4) / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / toll-like receptor 4 signaling pathway / toll-like receptor signaling pathway / extrinsic component of plasma membrane / JNK cascade / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / positive regulation of smooth muscle cell proliferation / cytokine-mediated signaling pathway / Interleukin-1 signaling / PIP3 activates AKT signaling / kinase activity / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / cellular response to lipopolysaccharide / positive regulation of canonical NF-kappaB signal transduction / endosome membrane / non-specific serine/threonine protein kinase / intracellular signal transduction / phosphorylation / innate immune response / protein serine kinase activity / protein serine/threonine kinase activity / protein kinase binding / cell surface / magnesium ion binding / extracellular space / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Interleukin-1 receptor-associated kinase 4 / IRAK4, Death domain / Death-like domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 Chem-QL7 / Interleukin-1 receptor-associated kinase 4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.74 Å |
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データ登録者 | Kiefer, J.R. / Bryan, M.C. / Lupardus, P.J. / Zarrin, A.A. / Rajapaksa, N.S. / Gobbi, A. / Drobnick, J. / Kolesnikov, A. / Liang, J. / Do, S. |
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引用 | ジャーナル: Acs Med.Chem.Lett. / 年: 2020 タイトル: Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. 著者: Rajapaksa, N.S. / Gobbi, A. / Drobnick, J. / Do, S. / Kolesnikov, A. / Liang, J. / Chen, Y. / Sujatha-Bhaskar, S. / Huang, Z. / Brightbill, H. / Francis, R. / Yu, C. / Choo, E.F. / DeMent, K. ...著者: Rajapaksa, N.S. / Gobbi, A. / Drobnick, J. / Do, S. / Kolesnikov, A. / Liang, J. / Chen, Y. / Sujatha-Bhaskar, S. / Huang, Z. / Brightbill, H. / Francis, R. / Yu, C. / Choo, E.F. / DeMent, K. / Ran, Y. / An, L. / Emson, C. / Maher, J. / Wai, J. / McKenzie, B.S. / Lupardus, P.J. / Zarrin, A.A. / Kiefer, J.R. / Bryan, M.C. |
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履歴 | 登録 | 2019年11月12日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年11月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年4月1日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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