登録情報 | データベース: PDB / ID: 6ta0 |
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タイトル | Human NAMPT in complex with nicotinic acid and phosphoribosyl pyrophosphate |
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要素 | Nicotinamide phosphoribosyltransferase |
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キーワード | TRANSFERASE / NAD biosynthesis / substrate complex |
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機能・相同性 | 機能・相同性情報
nicotinamide phosphoribosyltransferase / nicotinamide phosphoribosyltransferase activity / NAD biosynthesis via nicotinamide riboside salvage pathway / Nicotinamide salvaging / NAD biosynthetic process / positive regulation of nitric-oxide synthase biosynthetic process / NPAS4 regulates expression of target genes / BMAL1:CLOCK,NPAS2 activates circadian gene expression / cytokine activity / circadian regulation of gene expression ...nicotinamide phosphoribosyltransferase / nicotinamide phosphoribosyltransferase activity / NAD biosynthesis via nicotinamide riboside salvage pathway / Nicotinamide salvaging / NAD biosynthetic process / positive regulation of nitric-oxide synthase biosynthetic process / NPAS4 regulates expression of target genes / BMAL1:CLOCK,NPAS2 activates circadian gene expression / cytokine activity / circadian regulation of gene expression / cell junction / cell-cell signaling / nuclear speck / positive regulation of cell population proliferation / signal transduction / positive regulation of transcription by RNA polymerase II / extracellular exosome / identical protein binding / cytosol類似検索 - 分子機能 Nicotinamide phosphoribosyl transferase / Nicotinamide phosphoribosyltransferase, N-terminal domain / Nicotinamide phosphoribosyltransferase, N-terminal domain / Nicotinate/nicotinamide phosphoribosyltransferase / Nicotinate phosphoribosyltransferase (NAPRTase) family / Nicotinate phosphoribosyltransferase-like, C-terminal / Aldolase-type TIM barrel類似検索 - ドメイン・相同性 NICOTINIC ACID / Chem-PRP / Nicotinamide phosphoribosyltransferase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.58 Å |
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データ登録者 | Houry, D. / Raasakka, A. / Kursula, P. / Ziegler, M. |
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資金援助 | ノルウェー, 1件 組織 | 認可番号 | 国 |
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Research Council of Norway | 810882 | ノルウェー |
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引用 | ジャーナル: To Be Published タイトル: Identification of structural determinants of NAMPT activity and substrate selectivity 著者: Houry, D. / Raasakka, A. / Kursula, P. / Ziegler, M. |
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履歴 | 登録 | 2019年10月29日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2020年11月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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