PDB-6q94: Crystal structure of human GDP-D-mannose 4,6-dehydratase (S156D) ...

ID or keywords:

Entry

Database: PDB / ID: 6q94

Title

Crystal structure of human GDP-D-mannose 4,6-dehydratase (S156D) in complex with GDP-Man

Components

GDP-mannose 4,6 dehydratase

Keywords

LYASE / GDP-mannose 4 / 6 dehydratase / fucosylation / Structural Genomics / Structural Genomics Consortium / SGC

Function / homology

Function and homology information

GDP-L-fucose biosynthetic process / GDP-fucose biosynthesis / GDP-mannose 4,6-dehydratase / GDP-mannose 4,6-dehydratase activity / GDP-mannose metabolic process / 'de novo' GDP-L-fucose biosynthetic process / NADP+ binding / Notch signaling pathway / extracellular exosome / identical protein binding ...
Similarity search - Function

Biological species

Homo sapiens (human)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 2.8 Å

Authors

Pfeiffer, M. / Krojer, T. / Johansson, C. / von Delft, F. / Bountra, C. / Arrowsmith, C.H. / Edwards, A. / Nidetzky, B. / Oppermann, U. / Structural Genomics Consortium (SGC)

Citation

Journal: Acs Catalysis / Year: 2019
Title: A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase.
Authors: Pfeiffer, M. / Johansson, C. / Krojer, T. / Kavanagh, K.L. / Oppermann, U. / Nidetzky, B.

History

Deposition	Dec 17, 2018	Deposition site: PDBE / Processing site: PDBE
Revision 1.0	Apr 24, 2019	Provider: repository / Type: Initial release
Revision 1.1	May 15, 2024	Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	6q94.cif.gz	1.1 MB	Display	PDBx/mmCIF format
PDB format	pdb6q94.ent.gz	951.8 KB	Display	PDB format
PDBx/mmJSON format	6q94.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Summary document	6q94_validation.pdf.gz	5.3 MB	Display	wwPDB validaton report
Full document	6q94_full_validation.pdf.gz	5.4 MB	Display
Data in XML	6q94_validation.xml.gz	99.6 KB	Display
Data in CIF	6q94_validation.cif.gz	129.4 KB	Display
Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/q9/6q94 ftp://data.pdbj.org/pub/pdb/validation_reports/q9/6q94	HTTPS FTP

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Related structure data

Related structure data	6gpjC 6gpkC 6gplC C: citing same article (ref.)
Similar structure data	6gpk-d 6gpj-d 5in5-d 1t2a-d 6gpl-d 1kh2-d 5in4-d 2ac0-d Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

Related structure data

6gpjC

6gpkC

6gplC

C: citing same article (ref.)

Similar structure data

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Links

PDB pages	PDBj / wwPDB / NCBI

Deposited unit

B: GDP-mannose 4,6 dehydratase

A: GDP-mannose 4,6 dehydratase

C: GDP-mannose 4,6 dehydratase

D: GDP-mannose 4,6 dehydratase

E: GDP-mannose 4,6 dehydratase

F: GDP-mannose 4,6 dehydratase

G: GDP-mannose 4,6 dehydratase

H: GDP-mannose 4,6 dehydratase

hetero molecules

332 kDa, 8 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

B: GDP-mannose 4,6 dehydratase

A: GDP-mannose 4,6 dehydratase

hetero molecules

B: GDP-mannose 4,6 dehydratase

A: GDP-mannose 4,6 dehydratase

hetero molecules

defined by author&software
Evidence: gel filtration
166 kDa, 4 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

C: GDP-mannose 4,6 dehydratase

D: GDP-mannose 4,6 dehydratase

E: GDP-mannose 4,6 dehydratase

F: GDP-mannose 4,6 dehydratase

hetero molecules

defined by author&software
166 kDa, 4 polymers
Search similar-shape structures of this assembly by Omokage search (details)

3

G: GDP-mannose 4,6 dehydratase

H: GDP-mannose 4,6 dehydratase

hetero molecules

G: GDP-mannose 4,6 dehydratase

H: GDP-mannose 4,6 dehydratase

hetero molecules

defined by author&software
166 kDa, 4 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	101.620, 231.060, 383.890
Angle α, β, γ (deg.)	90.00, 90.00, 90.00
Int Tables number	20
Space group name H-M	C222₁

#1: Protein	GDP-mannose 4,6 dehydratase / GDP-D-mannose dehydratase / GMD Mass: 40084.473 Da / Num. of mol.: 8 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: GMDS / Production host: Escherichia coli (E. coli) / References: UniProt: O60547, GDP-mannose 4,6-dehydratase
#2: Chemical	ChemComp-NAP / NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / 2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE Mass: 743.405 Da / Num. of mol.: 8 Source method: isolated from a genetically manipulated source Formula: C₂₁H₂₈N₇O₁₇P₃
#3: Chemical	ChemComp-GDD / GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE Mass: 605.341 Da / Num. of mol.: 8 / Source method: obtained synthetically / Formula: C₁₆H₂₅N₅O₁₆P₂
#4: Chemical	ChemComp-EDO / 1,2-ETHANEDIOL / ETHYLENE GLYCOL Mass: 62.068 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C₂H₆O₂
#5: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 4 / Source method: isolated from a natural source / Formula: H₂O

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 3.45 Å³/Da / Density % sol: 64.32 %
Crystal grow	Temperature: 293 K / Method: vapor diffusion, sitting drop / pH: 5.5 Details: 25% PEG3350, 0.2M ammonium acetate, 0.1M bis-tris pH 5.5

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Data collection

Diffraction	Mean temperature: 100 K / Serial crystal experiment: N
Diffraction source	Source: SYNCHROTRON / Site: Diamond / Beamline: I04-1 / Wavelength: 0.92819 Å
Detector	Type: DECTRIS PILATUS3 S 6M / Detector: PIXEL / Date: Jul 5, 2017
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 0.92819 Å / Relative weight: 1
Reflection	Resolution: 2.8→115.53 Å / Num. obs: 111281 / % possible obs: 100 % / Redundancy: 6.7 % / Net I/σ(I): 9.4
Reflection shell	Resolution: 2.8→2.87 Å

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Processing

Software

Name	Version	Classification
PHENIX	(1.13_2998: ???)	refinement
XDS		data reduction
Aimless		data scaling
PHASER		phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT / Resolution: 2.8→115.53 Å / SU ML: 0.41 / Cross valid method: FREE R-VALUE / σ(F): 1.33 / Phase error: 25.46

	R_factor	Num. reflection	% reflection
R_free	0.235	5446	4.9 %
R_work	0.1863	-	-
obs	0.1887	111161	99.91 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å

Refinement step

Cycle: LAST / Resolution: 2.8→115.53 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	22128	0	648	4	22780

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.006	23308
X-RAY DIFFRACTION	f_angle_d	1.066	31687
X-RAY DIFFRACTION	f_dihedral_angle_d	18.14	13902
X-RAY DIFFRACTION	f_chiral_restr	0.089	3521
X-RAY DIFFRACTION	f_plane_restr	0.005	4191

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	1.823	0.923	-0.5986	1.0132	0.7412	2.0356	-0.0016	-0.0659	0.3154	-0.2407	-0.0065	0.2369	-0.6134	-0.0514	-0.0125	0.7778	-0.0032	0.0129	0.4639	0.1068	0.639	94.5505	255.858	-5.9538
2	0.3354	-0.1266	-0.051	0.8736	0.586	1.1282	0.0232	0.0212	0.0998	-0.0425	0.1152	-0.1948	-0.1481	0.235	-0.1197	0.6286	-0.0503	0.0256	0.525	0.0459	0.6322	106.7205	245.5659	0.262
3	0.812	-0.296	-0.1876	2.0766	1.5166	1.282	0.0491	-0.031	0.144	0.2743	0.3497	-0.4086	0.0925	0.3668	-0.3278	0.5836	-0.0325	-0.0284	0.5991	-0.0442	0.7601	114.6599	253.4061	17.9075
4	3.5605	-1.6124	0.05	3.6087	0.7556	3.2542	0.0092	-0.1614	0.7874	-0.4396	0.1166	-0.6137	-0.878	0.2227	-0.0419	0.8372	-0.1416	0.0826	0.5475	-0.0632	0.7832	105.3084	266.0478	13.8033
5	1.6468	0.1896	0.0181	0.9792	0.1513	0.7941	0.0114	0.0437	0.4101	0.0212	0.0237	-0.0776	-0.281	0.0063	-0.0314	0.6842	-0.0045	0.0374	0.5351	0.0313	0.638	81.0284	247.6433	19.3092
6	1.2815	0.6347	-0.3165	1.2473	-0.3518	0.8314	0.2367	-0.3279	0.2019	0.4879	0.3347	-0.7043	-0.2098	0.382	-0.774	0.7408	-0.0614	-0.0229	0.5396	-0.0871	0.6487	86.5858	248.8941	21.7311
7	0.7666	0.253	-0.38	1.1987	-0.3776	1.3672	0.0011	-0.1064	0.1456	0.0595	0.0429	0.2534	-0.1077	-0.0779	-0.045	0.5884	-0.0011	0.0239	0.5132	0.0958	0.6427	72.0475	243.1512	7.8839
8	0.6144	0.7254	-0.066	1.5425	0.2606	0.1782	0.0249	-0.0811	0.3249	-0.1232	-0.0668	0.3643	-0.3626	-0.0733	0.0056	0.7939	0.1536	0.0086	0.5883	0.1408	0.9319	64.1656	262.2715	-1.468
9	0.6689	0.5053	-0.0841	0.5832	-0.1955	0.2236	0.1038	0.0223	0.4606	0.0687	-0.1366	0.3712	-0.6355	-0.5651	-0.1615	0.7671	0.1659	0.0343	0.755	0.1039	0.9397	59.4427	247.3773	7.8867
10	5.3877	3.2134	0.7149	7.3655	0.0228	4.974	0.5064	-0.5005	0.8039	1.1718	-0.3445	0.6489	-0.609	-0.2476	-0.1494	0.8257	0.0468	0.0914	0.5499	-0.0326	0.9773	73.105	267.5273	9.9666
11	2.2793	-0.945	-0.594	0.7262	-0.4164	1.7407	-0.1235	-0.1418	-0.5861	0.0332	0.179	0.2802	0.1765	-0.2746	-0.011	0.6668	-0.1957	0.0116	0.7146	0.051	0.6418	82.085	279.9065	42.0655
12	0.9582	0.2117	-0.5301	0.8846	-0.4349	0.9835	0.0995	-0.0475	0.1506	0.0938	0.0673	0.1656	-0.1388	-0.2154	-0.1439	0.5973	-0.0945	0.0562	0.6785	0.0351	0.6233	82.2757	295.7373	48.79
13	1.3427	-0.0224	-1.4399	1.0234	-0.7279	2.0988	0.1464	-0.1377	0.2396	0.3296	0.2437	0.3422	-0.333	-0.3392	-0.3404	0.7735	-0.076	0.1657	0.8045	0.0264	0.7639	70.61	297.4787	62.4682
14	2.3778	-2.2016	0.3743	9.4851	-1.6712	3.4986	-0.2959	-0.5876	-0.499	-0.9772	1.2023	1.4393	0.7258	-1.0698	-0.8907	0.7833	-0.2375	0.0318	1.0159	0.2055	0.7257	67.7208	280.989	61.9528
15	0.944	-0.9102	-0.0132	1.2415	-0.7503	1.5653	0.4243	-0.3925	0.1784	0.3184	-0.1453	-0.3215	-0.8195	0.0363	-0.0233	0.9976	-0.3747	0.0182	0.8259	-0.1596	0.7909	114.5792	319.9756	56.2013
16	0.7082	-1.1338	-0.1277	2.0473	-0.4467	1.8057	0.4362	-0.3209	0.4887	0.1905	-0.6332	-0.4325	-0.0634	0.155	0.0562	0.8744	-0.3247	0.0102	0.7681	-0.0622	0.8467	120.4826	311.3034	52.4684
17	1.1912	-0.4504	-0.4835	1.073	-0.3183	1.0964	0.0945	-0.2603	0.2491	0.3364	-0.1286	-0.0221	-0.0217	0.2266	-0.0809	0.6842	-0.3044	0.055	0.7227	-0.067	0.6204	106.352	305.9756	52.5382
18	0.9797	0.166	-0.1518	0.5494	-0.0671	0.7889	0.1491	-0.2436	0.481	0.2961	-0.1228	0.1209	-0.4732	-0.0357	-0.0568	0.8164	-0.1245	0.1685	0.6364	-0.096	0.7428	94.414	314.0996	51.6183
19	1.1097	0.2827	-0.5752	0.916	0.0542	1.136	0.2133	-0.0286	0.3074	0.4053	-0.2009	-0.0775	-0.3593	-0.058	-0.0073	0.8136	-0.1816	0.1537	0.6061	0.0169	0.9059	107.801	323.2428	40.0622
20	1.9602	0.0745	-1.6125	1.2094	-0.6957	2.9124	0.8555	-0.1358	0.987	0.7391	-0.0056	0.3608	-1.6662	-0.0406	-0.8901	1.084	-0.1897	0.2885	0.6118	-0.03	1.1813	101.7169	329.0007	40.5365
21	1.9542	0.9662	-0.6597	1.8396	-0.7531	0.9929	0.1169	0.4109	0.5716	-0.0273	0.2444	0.3133	-0.0717	-0.6505	-0.3157	0.6681	-0.0857	0.0918	0.7325	0.2182	0.9915	105.9941	325.6979	17.4157
22	1.5616	0.3932	-0.8466	0.2833	-0.32	0.6585	0.4435	-0.4817	0.6559	0.2845	-0.1501	0.2497	-0.9758	-0.304	-0.3489	1.1734	-0.0553	0.2458	0.7797	-0.0142	1.0717	96.7615	326.4468	44.4261
23	4.8445	0.9196	-0.4773	2.2363	-0.2473	4.4584	0.7402	-0.2654	1.5832	0.7545	-0.3327	-0.3502	-1.2645	0.5012	-0.3597	1.0739	-0.3008	0.1592	0.7546	-0.0421	1.0466	118.3518	329.1431	34.1694
24	2.2861	-0.4267	0.9348	2.0047	-0.6757	1.8965	0.1429	-0.461	-0.2949	0.4069	0.1457	0.4013	0.1065	-0.1461	-0.2305	0.7617	-0.1746	-0.0083	0.8808	0.0526	0.5384	95.7401	277.1515	68.1071
25	1.111	0.4707	0.07	1.0812	-0.3219	1.3672	0.1068	-0.2563	-0.258	0.2219	-0.1526	-0.1434	0.2887	0.1637	0.0527	0.6704	-0.0867	-0.0537	0.6619	0.0776	0.6114	104.5743	268.0206	53.4098
26	1.6546	0.8167	0.598	1.5074	-0.1672	1.7717	0.1112	-0.5855	-0.4435	0.1067	-0.0519	0.0408	0.819	-0.0263	-0.1263	0.8256	-0.0479	-0.0587	0.6285	0.1639	0.6709	101.2087	258.7911	56.9833
27	2.7072	-0.7895	-0.2519	1.8244	0.6101	2.1088	0.081	0.3145	0.5119	-0.0013	-0.0698	-0.6936	-0.2449	0.4332	-0.0529	0.6377	-0.1152	0.0412	0.7083	0.1257	0.7187	120.6884	300.8258	27.8743
28	1.6734	0.6789	-0.6252	2.1986	-0.5541	1.1748	0.2689	-0.3051	0.0845	0.287	-0.381	-0.6996	-0.0179	0.4566	0.1005	0.5268	-0.1122	-0.0827	0.7238	0.1106	0.771	129.1517	291.0118	42.6834
29	1.5377	1.9038	0.7484	2.4045	0.9688	1.6068	-0.0085	0.032	0.1187	-0.0733	-0.0795	-0.7043	0.0227	0.7266	0.1125	0.6586	-0.0045	-0.0632	1.0251	0.2332	1.1186	138.6335	293.9864	39.3297
30	2.8562	-0.6131	0.2241	1.2291	-0.3685	1.8613	0.3308	0.4288	-0.1197	-0.2429	0.0591	0.2228	0.1005	-0.5183	-0.4201	0.7825	-0.012	0.0034	0.9605	-0.0145	0.5721	135.8255	266.7134	76.7142
31	1.5632	0.237	0.4496	1.0856	0.3952	2.2986	0.1453	0.0737	-0.053	-0.0368	-0.0637	0.2034	-0.1679	-0.0216	-0.0895	0.644	0.0318	0.0837	0.7873	-0.0002	0.4567	144.2838	272.6518	85.5266
32	1.7788	0.0116	-0.0136	0.6747	0.4525	2.0473	0.2576	-0.0801	0.1792	-0.0258	-0.0715	0.1214	-0.3941	-0.7111	-0.0216	0.6866	0.1178	0.0684	1.0522	0.0616	0.6393	125.0996	278.3579	89.9941
33	1.8893	-0.2038	0.6056	0.2913	0.1633	1.5916	-0.0809	-0.1852	0.2645	-0.0294	0.0214	0.2046	-0.2329	-0.8759	0.0198	0.8284	0.1847	0.0678	1.1282	-0.0602	0.6297	121.5072	283.7493	97.5732
34	1.5535	0.6408	-0.4148	1.748	-0.0519	0.1758	-0.4123	-0.3427	0.2243	-0.1857	0.2009	-0.0931	-0.237	-0.1379	0.1385	0.9575	0.1699	0.0657	0.8839	0.0939	0.6827	136.0368	288.6352	87.5686
35	5.4268	3.2489	0.0962	5.8151	0.0719	3.203	-0.3268	0.8774	-0.3084	-1.087	0.278	-0.0127	-0.2043	-1.0504	0.0591	0.8748	0.1509	0.0913	1.2205	0.0644	0.659	115.9695	274.269	86.3432
36	1.6815	-0.0824	0.9587	1.5668	0.826	1.6493	0.5107	-0.1231	-0.6033	-0.037	-0.041	0.2616	0.7526	-0.4364	-0.0649	1.0656	-0.2353	-0.0867	1.0968	0.2423	0.8307	126.9923	247.3741	103.6807
37	1.1303	0.3045	0.0119	1.1571	0.1001	0.8569	-0.0037	-0.185	-0.3574	-0.1905	-0.0971	0.2653	0.2401	-0.6015	-0.0473	0.8648	-0.1872	-0.0435	1.1539	0.1785	0.7143	128.7098	256.7695	100.6675
38	1.0225	-0.0144	0.4738	1.5087	-0.1664	2.2988	0.2487	-0.0975	-0.4004	0.0624	0.1223	0.0938	0.1856	-0.0409	-0.4214	0.8893	-0.0881	-0.1267	0.905	0.0803	0.7462	142.2672	251.2833	100.3515
39	1.9046	0.1142	-0.4872	1.8076	-0.4459	1.1363	0.3396	-0.2603	-0.9884	-0.0051	-0.0808	0.3804	0.6951	-0.3167	-0.1848	1.2564	-0.1588	-0.3714	0.7882	0.1405	1.1401	145.2501	237.2709	99.4049
40	1.4842	-0.0314	0.6437	1.6955	-0.915	1.8096	0.3426	-0.0522	-0.6234	-0.2148	-0.0511	0.0731	0.6948	-0.6079	-0.3549	1.1602	-0.104	-0.3523	0.8789	0.0012	1.1715	129.0978	241.7162	83.5848
41	1.4558	0.0741	-0.5174	1.1263	-0.2382	0.2353	0.4764	0.148	-0.9235	-0.0188	-0.0487	0.0135	0.5805	0.1584	-0.3362	1.1888	-0.1432	-0.4289	0.8847	0.0023	1.2027	129.1081	234.6151	82.1355
42	0.36	-0.3694	0.1867	0.6072	-0.2986	0.1351	0.2985	-0.1136	-0.913	0.4639	0.0289	-0.1378	0.5427	-0.1595	-0.3528	1.3589	-0.1992	-0.3768	0.9108	0.0907	1.4111	134.1053	229.64	93.66
43	3.8585	-0.1751	0.1649	1.516	-0.1035	3.1026	-0.2309	-0.1131	-0.4739	-0.2263	0.1488	-0.1404	-0.1927	-0.7884	0.1891	1.1121	-0.281	-0.4083	1.1844	0.0966	1.1663	117.5157	243.2015	82.1117

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	chain 'B' and (resid 23 through 89 )
2	X-RAY DIFFRACTION	2	chain 'B' and (resid 90 through 280 )
3	X-RAY DIFFRACTION	3	chain 'B' and (resid 281 through 350 )
4	X-RAY DIFFRACTION	4	chain 'B' and (resid 351 through 372 )
5	X-RAY DIFFRACTION	5	chain 'A' and (resid 23 through 65 )
6	X-RAY DIFFRACTION	6	chain 'A' and (resid 66 through 89 )
7	X-RAY DIFFRACTION	7	chain 'A' and (resid 90 through 264 )
8	X-RAY DIFFRACTION	8	chain 'A' and (resid 265 through 323 )
9	X-RAY DIFFRACTION	9	chain 'A' and (resid 324 through 350 )
10	X-RAY DIFFRACTION	10	chain 'A' and (resid 351 through 372 )
11	X-RAY DIFFRACTION	11	chain 'C' and (resid 23 through 89 )
12	X-RAY DIFFRACTION	12	chain 'C' and (resid 90 through 264 )
13	X-RAY DIFFRACTION	13	chain 'C' and (resid 265 through 350 )
14	X-RAY DIFFRACTION	14	chain 'C' and (resid 351 through 372 )
15	X-RAY DIFFRACTION	15	chain 'D' and (resid 23 through 46 )
16	X-RAY DIFFRACTION	16	chain 'D' and (resid 47 through 89 )
17	X-RAY DIFFRACTION	17	chain 'D' and (resid 90 through 141 )
18	X-RAY DIFFRACTION	18	chain 'D' and (resid 142 through 197 )
19	X-RAY DIFFRACTION	19	chain 'D' and (resid 198 through 264 )
20	X-RAY DIFFRACTION	20	chain 'D' and (resid 265 through 292 )
21	X-RAY DIFFRACTION	21	chain 'D' and (resid 293 through 323 )
22	X-RAY DIFFRACTION	22	chain 'D' and (resid 324 through 350 )
23	X-RAY DIFFRACTION	23	chain 'D' and (resid 351 through 372 )
24	X-RAY DIFFRACTION	24	chain 'E' and (resid 23 through 89 )
25	X-RAY DIFFRACTION	25	chain 'E' and (resid 90 through 323 )
26	X-RAY DIFFRACTION	26	chain 'E' and (resid 324 through 372 )
27	X-RAY DIFFRACTION	27	chain 'F' and (resid 23 through 89 )
28	X-RAY DIFFRACTION	28	chain 'F' and (resid 90 through 323 )
29	X-RAY DIFFRACTION	29	chain 'F' and (resid 324 through 372 )
30	X-RAY DIFFRACTION	30	chain 'G' and (resid 23 through 65 )
31	X-RAY DIFFRACTION	31	chain 'G' and (resid 66 through 218 )
32	X-RAY DIFFRACTION	32	chain 'G' and (resid 219 through 264 )
33	X-RAY DIFFRACTION	33	chain 'G' and (resid 265 through 323 )
34	X-RAY DIFFRACTION	34	chain 'G' and (resid 324 through 350 )
35	X-RAY DIFFRACTION	35	chain 'G' and (resid 351 through 372 )
36	X-RAY DIFFRACTION	36	chain 'H' and (resid 23 through 45 )
37	X-RAY DIFFRACTION	37	chain 'H' and (resid 46 through 89 )
38	X-RAY DIFFRACTION	38	chain 'H' and (resid 90 through 141 )
39	X-RAY DIFFRACTION	39	chain 'H' and (resid 142 through 197 )
40	X-RAY DIFFRACTION	40	chain 'H' and (resid 198 through 245 )
41	X-RAY DIFFRACTION	41	chain 'H' and (resid 246 through 323 )
42	X-RAY DIFFRACTION	42	chain 'H' and (resid 324 through 350 )
43	X-RAY DIFFRACTION	43	chain 'H' and (resid 351 through 372 )

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